Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Aplastic anemia)
20,952 results
  • [Hematologic responses to avatrombopag switch in TPO-RA refractory aplastic anemia]. [Journal Article]
    Zhonghua Xue Ye Xue Za Zhi. 2022 Nov 14; 43(11):921-927.Jing LP, Fan HH, … Zhang FK
  • Objective: Short-term efficacy and safety of afatrombopag conversion therapy in patients with aplastic anemia (AA) who were previously ineffectively treated with intense immunosuppressive therapy (IST) combined with TPO receptor Agonist (TPO-RA) or who were unable to tolerate the side effects of TPO-RA. Methods: Analysis of patients with severe aplastic anemia (SAA) treated in Institute of Hemato…
  • [The characterization analysis of pathogenic T cells in immune-mediated aplastic anemia mouse model]. [Journal Article]
    Zhonghua Xue Ye Xue Za Zhi. 2022 Jul 14; 43(7):587-593.Jia H, Lin ZH, … Liu H
  • Objective: This study aims, in addition to characterizing pathogenic T cells trafficking to bone marrow (BM) and other organs, to establish immune-mediated AA C.B10 mouse model by DsRed mouse (B6 background) lymph nodes (LN) cells infusion after a total body irradiation (TBI) . Methods: The C.B10 mice received a 5 Gy TBI and then were infused with DsRed mouse (B6 background) LN cells at 5×10(6)/m…
  • [Kinetics of immune activated T cells in aplastic anemia mouse model]. [Journal Article]
    Zhonghua Xue Ye Xue Za Zhi. 2022 Jul 14; 43(7):581-586.Li WW, Li RN, … Shi J
  • Objective: To explore the dynamic changes of donor derived T cells at different time points in the aplastic anemia mouse model. Methods: The aplastic anemia mouse model was induced and then the proportion of infiltrated donor derived T cells in spleen and bone marrow, expression of activation molecular markers, cell cycle and functional subsets were measured by flow cytometry at different time po…
  • Utility of Whole Exome Sequencing in the Early Diagnosis of Atypical Diamond-Blackfan Anemia. [Journal Article]
    J Pediatr Hematol Oncol. 2023 Jan 09 [Online ahead of print]Abdulla AM, Frances A, Helou M
  • Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure syndrome, with a hallmark of erythroblastopenia and congenital anomalies. DBA demonstrates genetic heterogeneity and variable phenotypic expression. We present 2 cases of atypical DBA harboring de novo mutations in the RPS-19 gene with c.49 G>C and c.357-1G>T allelic variants. The 2 cases presented confounding critical illness…
  • Rise of the planet of rare anemias: An update on emerging treatment strategies. [Review]
    Front Med (Lausanne). 2022; 9:1097426.Fattizzo B, Motta I
  • Therapeutic options for rare congenital (hemoglobinopathies, membrane and enzyme defects, congenital dyserythropoietic anemia) and acquired anemias [warm autoimmune hemolytic anemia (wAIHA), cold agglutinin disease CAD, paroxysmal nocturnal hemoglobinuria (PNH), and aplastic anemia (AA)] are rapidly expanding. The use of luspatercept, mitapivat and etavopivat in beta-thalassemia and pyruvate kina…
  • A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene. [Journal Article]
    Nat Commun. 2023 Jan 24; 14(1):381.Gao Y, Guitton-Sert L, … Masson JY
  • Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a deficiency in repairing DNA crosslinks, which are known to perturb several cellular processes, including DNA transcription, replication, and repair. Formaldehyde, a by-product of metabolism, is thought to drive FA by generating DNA interstrand crosslinks (ICLs) and DNA-protein crosslinks (DPCs). However, the i…
  • Aplastic Anemia in Triple X Syndrome. [Case Reports]
    Children (Basel). 2023 Jan 03; 10(1)Aldarwish M, Alaithan I, Alawami F
  • Triple X syndrome is the most common sex chromosome aneuploidies (SCA) in females. Still, it is underdiagnosed because patients are usually without clear dysmorphism, and the syndrome is not associated with any significant congenital anomalies. We are reporting a case of a 5-year-old girl who presented with aplastic anemia, confirmed by a bone marrow aspiration and biopsy. Her complete workup sho…
  • [Chinese expert consensus on the diagnosis and treatment of Fanconi anemia (version 2022)]. [Journal Article]
    Zhonghua Yi Xue Za Zhi. 2023 Jan 31; 103(4):235-241.Red blood cell disease (anemia) group, Hematology Branch of Chinese Medical Association
  • Fanconi anemia (FA) is an autosomal recessive or X-linked hereditary bone marrow failure disease, in which mutations or deletions of FA-related genes lead to abnormalities in DNA repairment after damage and DNA cross-linking repair. The most common mutation genes include FANCA, FANCC, FANCG, FANCE and FANCF. FA is a disorder with high phenotypic and genotypic heterogeneity and mainly manifests as…
  • A Case with Iron Deficiency Anemia Developed Aplastic Crisis. [Journal Article]
    Kobe J Med Sci. 2022 Jul 06; 68(1):E1-E4.Iketani K, Minamikawa S, … Nakagishi Y
  • A toddler with an unbalanced diet and gastrointestinal bleeding by juvenile polyp developed an aplastic crisis due to the human parvovirus B19 (HPVB19). Although he exhibited microcytic anemia without iron deficiency in the acute phase of HPVB19 infection, he presented with iron deficiency anemia (IDA) in the chronic phase. IDA results in erythroblast hyperplasia and shortened red blood cell life…
  • Prolonged use of eltrombopag in patients with severe aplastic anemia in the real world. [Journal Article]
    Clin Exp Med. 2023 Jan 16 [Online ahead of print]Li R, Wang N, … Li J
  • Eltrombopag (EPAG) can improve the efficacy of immunosuppressive therapy (IST) consisting of antithymocyte immunoglobulin (ATG) and cyclosporin in severe aplastic anemia (SAA) patients. This study explored whether patients with SAA could benefit from continuous usage of EPAG beyond 6 months.Seventy-four treatment-naive Chinese patients with SAA were administrated with rabbit ATG-based IST plus EP…
  • Current status of producing autologous hematopoietic stem cells. [Review]
    Curr Res Transl Med. 2023 Jan 05; 71(1):103377.Li Z, Yang L
  • Hematopoietic stem cells (HSCs) transplantation is an established therapy for many diseases of the hematopoietic system, for example aplastic anemia, acute myeloid leukemia and acute lymphoblastic leukemia. With the development of the HSCs research, HSCs provide an attractive method for treating hereditary blood disorders and immunotherapy of cancer by introducing gene modification. Compared with…
  • Extraction, structure and bioactivities of polysaccharides from Rehmannia glutinosa: A review. [Review]
    J Ethnopharmacol. 2023 Apr 06; 305:116132.Bian Z, Zhang R, … Liu Y
  • CONCLUSIONS: Based on its effects of promoting hematopoiesis, antitumor and enhancing immunity, RGPs have been clinically applied in the treatment of chronic aplastic anemia and esophageal cancer, but other effects of RGPs have not been reflected in the clinical practice. In the future, more in-depth research can be conducted on the molecular structure analysis, toxicity, side effects and clinical pharmacological effects of RGPs to further explore the pharmacological effects of RGPs and to lay the foundation for safe clinical application and expansion of application scope.
New Search Next