- Sleep-disordered breathing in pediatric head and neck vascular malformations. [Journal Article]
- LLaryngoscope 2017 Jan 16
- CONCLUSIONS: Nearly half of children with head and neck vascular malformations have SDB symptoms. Children with head and neck vascular malformations have a higher OSA-18 score and lower overall QOL score when compared to children with non-head and neck vascular malformations.
- Will wearing dentures affect edentulous patients' breathing during sleep? [Journal Article]
- SBSleep Breath 2017 Jan 14
- CONCLUSIONS: Wearing dentures can lead to significant increase of AHI and diastolic MBP among edentulous people. Hence, we suggest that Chinese edentulous people should remove their dentures before sleep.
- Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice. [Journal Article]
- JPJ Physiol 2017 Jan 15
- Pregnancy, particularly late gestation, has been associated with a relatively high prevalence of obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, could impose significant ...
Pregnancy, particularly late gestation, has been associated with a relatively high prevalence of obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, could impose significant long-term effects on somatic growth, energy homeostasis, and metabolic function in offspring. We hypothesized that IH during late pregnancy (LG-IH) may increase the propensity for metabolic dysregulation and obesity in adult offspring via epigenetic modifications. Time-pregnant female C57BL/6 mice were exposed to LG-IH or room air (LG-RA) during days 13-18 of gestation. At 24 weeks, blood samples were collected from offspring mice for lipid profiles and insulin resistance (HOMA-IR), indirect calorimetry was performed, and visceral white adipose tissues (VWAT) were assessed for inflammatory cells as well as for differentially methylated gene regions (DMR) using MeDIP-Chip. Body weight, food intake, adiposity index, fasting insulin, triglycerides, and cholesterol levels were all significantly higher in LG-IH male but not female offspring. LG-IH also altered metabolic expenditure and locomotor activities in male offspring, and increased number of pro-inflammatory macrophages emerged in VWAT along with 1520 DMRs (P < 0.0001), associated with 693 genes. Pathway analyses showed that genes affected by LG-IH were mainly associated with molecular processes related to metabolic regulation and inflammation. LG-IH induces metabolic dysfunction as reflected by increased body weight and adiposity index in adult male offspring that is paralleled by epigenomic alterations and inflammation in VWAT. Thus, perturbations to fetal environment by OSA during pregnancy can therefore have long-term detrimental effects to the fetus, and lead to persistent metabolic dysfunction in adulthood. This article is protected by copyright. All rights reserved.
- Sleep Disturbances and Neurobehavioral Performance in Juvenile Idiopathic Arthritis. [Journal Article]
- JRJ Rheumatol 2017 Jan 15
- CONCLUSIONS: Elevated OAHI is suggestive of obstructive sleep apnea and a comorbidity in JIA that may predispose children with JIA to daytime sleepiness and impaired neurobehavioral performance.
- New Uses for Old Biomarkers in chronic obstructive pulmonar disease and Obstructive Sleep Apnea? [Journal Article]
- ABArch Bronconeumol 2017 Jan 12
- Exploiting temporal and nonstationary features in breathing sound analysis for multiple obstructive sleep apnea severity classification. [Journal Article]
- BEBiomed Eng Online 2017 Jan 07; 16(1):6
- CONCLUSIONS: The results show that our proposed method can be used as part of an OSA screening test, which can provide the subject with detailed OSA severity results from only breathing sounds.
- [Sleep at Altitude]. [Journal Article]
- PPneumologie 2017 Jan 13
- Advancing infrastructure of mountain regions allows not only well-prepared mountaineers, but also elderly people with pre-existing illness the stay at high altitudes. Based on the hypoxic conditions,...
Advancing infrastructure of mountain regions allows not only well-prepared mountaineers, but also elderly people with pre-existing illness the stay at high altitudes. Based on the hypoxic conditions, low oxygen saturation values are reached, which cause severe hypoxemia in the tissue. Symptoms of acute mountain sickness appear even at moderate altitude, which are manifested during sleep. Patients suffering from sleep apnea are at high risk, because of the obstructive ventilation disorder in combination with less oxygen availability. Concurrently, gender differences play a decisive role. Due to the respiratory stabilizing impact of estrogen, women are faster in adapting to altitude differences. A reduction of sleep duration and extended wake phases are shown, which causes lower sleep sufficiency. With continued rise of altitude, the arousal-index increases. For individual differences concerning altitude induced problems, individual acclimatization protocols are needed. Well prepared pre-acclimatization could prevent altitude induced sleep problems, as well as the treatment of such.
- Obstructive sleep apnea risk and leukocyte telomere length in African Americans from the MH-GRID study. [Journal Article]
- SBSleep Breath 2017 Jan 12
- CONCLUSIONS: Our findings suggest that OSA risk may contribute to the acceleration of cellular aging processes through telomere shortening.
- Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial on psychological distress. [Journal Article]
- COClin Oral Investig 2017 Jan 12
- CONCLUSIONS: There is no significant difference between MAD, nCPAP, and an intraoral placebo appliance in their beneficial effects on symptoms of psychological distress.The improvement in psychological distress symptoms in mild/moderate OSA patients under MAD or nCPAP treatment may be explained by a placebo effect.
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- Losartan Reduces the Immediate and Sustained Increases in Muscle Sympathetic Nerve Activity after Hyper-Acute Intermittent Hypoxia. [Journal Article]
- JAJ Appl Physiol (1985) 2017 Jan 12; :jap.00683.2016
- Obstructive sleep apnea (OSA) is characterized by intermittent hypoxemia (IH), which produces elevations in sympathetic nerve activity (SNA) and associated hypertension in experimental models that pe...
Obstructive sleep apnea (OSA) is characterized by intermittent hypoxemia (IH), which produces elevations in sympathetic nerve activity (SNA) and associated hypertension in experimental models that persist beyond the initial exposure. We tested the hypotheses that angiotensin receptor blockade in humans using Losartan attenuates the immediate and immediately persistent increases in (a) SNA discharge and (b) mean arterial pressure (MAP) after hyper-acute intermittent hypoxia training (IHT) using a randomized, placebo controlled repeated-measures experimental design. We measured ECG and photoplethysmographic arterial pressure in 9 healthy human subjects, while muscle sympathetic nerve activity (MSNA) was recorded in 7 subjects using microneurography. Subjects were exposed to a series of hypoxic apneas in which they inhaled 2-3 breaths of nitrogen, followed by a 20-second apnea and 40 seconds of room air breathing every minute for 20 minutes. Hyper-acute IHT produced substantial and persistent elevations in MSNA burst frequency (baseline: 15.3 ± 1.8, IHT: 24 ± 1.5, post-IHT 20.0 ± 1.3 bursts/min, all P < 0.01) and MAP (baseline: 89.2 ± 3.3, IHT: 92.62 ± 3.1, post-IHT: 93.83 ± 3.1 mm Hg mm Hg, all P < 0.02). Losartan attenuated the immediate and sustained increases in MSNA (baseline: 17.3 ± 2.5, IHT: 18.6 ± 2.2, post-IHT 20.0 ± 1.3 bursts/min, all P < 0.001) and MAP (baseline: 81.9 ± 2.6, IHT: 81.1 ± 2.8, post-IHT: 81.3 ± 3.0 mm Hg, all P >0.70). This investigation confirms the role of angiotensin II type 1a receptors in the immediate and persistent sympathoexcitatory and pressor responses to IHT.