- Comorbid obstructive sleep apnea and increased risk for sickle cell disease morbidity. [Journal Article]
- SBSleep Breath 2018 Feb 15
- CONCLUSIONS: OSA in children with SCD is associated with higher rates of a broad range of SCD complications, including pneumonia and acute chest syndrome. Routine screenings, diagnosis, and increased therapeutic intervention for children with comorbid OSA could decrease SCD morbidity.
- Association of Adenotonsillectomy With Blood Pressure Among Hypertensive and Nonhypertensive Children With Obstructive Sleep Apnea. [Journal Article]
- JOJAMA Otolaryngol Head Neck Surg 2018 Feb 15
- CONCLUSIONS: Hypertensive children with OSA had a significant improvement in BP after adenotonsillectomy. Hypertensive children with OSA should be screened and treated by adenotonsillectomy because proper treatment not only eases OSA symptoms but also potentially prevents future cardiovascular and end-organ disease.
- Kinesthetic stimulation for obstructive sleep apnea syndrome: An "on-off" proof of concept trial. [Journal Article]
- SRSci Rep 2018 Feb 15; 8(1):3092
- Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses due to the loss of upper airway muscle activation at sleep onset. This study investigated the effectiveness of triggere...
Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses due to the loss of upper airway muscle activation at sleep onset. This study investigated the effectiveness of triggered kinesthetic stimulation in patients with OSA. This proof-of-concept, open-label, multicenter prospective study was conducted on 24 patients with severe OSA. During a one night evaluation, kinesthetic stimulation was intermittently delivered in 30 minute periods. The duration of apneas and hypopneas during Stimonand Stimoffperiods were compared. Five hospital-based university centers in France participated. Sleep studies were evaluated by a single scorer at a core laboratory (CHU Grenoble). Results show that during the Stimonphases, statistically significant decreases in durations of apneas and hypopneas were observed in 56% and 46% of patients, respectively. Overall, 75% of patients showed an improvement in apneas or hypopneas durations. The mean reduction in durations for patients with a significant decrease was 4.86 seconds for apneas and 6.00 seconds for hypopneas. This proof of concept study is the first to identify kinesthetic stimulation as a potentially effective therapy for OSA. These data justify evaluation in a controlled study.
- Sex differences in the associations of obstructive sleep apnoea with epidemiologic factors. [Journal Article]
- EREur Respir J 2018 Feb 15
- Despite well-known male predominance in the prevalence of obstructive sleep apnoea (OSA), sex differences in the associations between OSA and a comprehensive range of epidemiologic factors remain les...
Despite well-known male predominance in the prevalence of obstructive sleep apnoea (OSA), sex differences in the associations between OSA and a comprehensive range of epidemiologic factors remain less clear.We examined the prevalence of self-reported OSA in 143 326 women (age: 48-93) from the Nurses' Health Study (NHS) and NHSII and 22 896 men from the Health Professionals Follow-up Study (age: 65-101) in 2012-2013. Multivariable logistic regression was used to estimate the sex-specific prevalence odds ratios (pOR) and 95% CIs of OSA by demographic, anthropometric, lifestyle and co-morbidity factors.The overall prevalence of self-reported OSA was 6.4% in women and 13.8% in men. After mutual adjustment, the associations of OSA with physical inactivity, hypertension, and daytime sleepiness were stronger in women, whereas the associations with waist circumference and witnessed apnoea were stronger in men (P-heterogeneity<0.01). There were qualitative sex differences in the associations with age (pOR per 5-year increment in women: 0.95; 95% CI: 0.94, 0.96; men: 1.04; 95% CI: 1.01, 1.08; P-heterogeneity<0.0001) and marital status (pOR for marriedversusother in women: 0.85; 95% CI: 0.81, 0.89; men: 1.11; 95% CI: 0.99, 1.25; P-heterogeneity<0.0001).Substantial sex differences exist in the associations with various factors, suggesting sex-specific mechanisms in OSA.
- Restoration of sleep using a novel biomimetic protocol for adult OSA: Clinical case report. [Journal Article]
- CCranio 2018 Feb 15; :1-4
- Background A sleep study of a 56-year old male with excessive daytime sleepiness demonstrated an AHI of 16.4hr-1with 13% of total sleep time in REM sleep and a mean oxygen desaturation (SpO2) of 86%....
Background A sleep study of a 56-year old male with excessive daytime sleepiness demonstrated an AHI of 16.4hr-1with 13% of total sleep time in REM sleep and a mean oxygen desaturation (SpO2) of 86%. Clinical presentation On intra-oral examination, it was found that the patient had maxillary hypoplasia and bilateral torus mandibularis. A 3D cone-beam CT (CBCT) scan was taken, and 28 craniofacial parameters were measured. Surgical reduction of the mandibular tori followed by biomimetic oral appliance therapy (BOAT) was initiated. After 14 months, a post-treatment CBCT scan revealed that 70% of parameters measured had improved. Therefore, another sleep study was performed with no device in the mouth. This follow-up home sleep test demonstrated that the AHI fell to 5.3hr-1hr; with 27% REM sleep, and a mean SpO2of 93% without any device in the mouth. Conclusion These findings suggest that BOAT might be able to restore sleep in certain adult cases.
- GeneReviews® [BOOK]
- BOOKUniversity of Washington, Seattle: Seattle (WA)
- Bohring-Opitz syndrome (BOS) is characterized by distinctive facial features and posture, growth failure, variable but usually severe intellectual disability, and variable anomalies. The facial featu...
Bohring-Opitz syndrome (BOS) is characterized by distinctive facial features and posture, growth failure, variable but usually severe intellectual disability, and variable anomalies. The facial features may include microcephaly or trigonocephaly / prominent (but not fused) metopic ridge, hypotonic facies with full cheeks, synophrys, glabellar and eyelid nevus flammeus (simplex), prominent globes, widely set eyes, palate anomalies, and micrognathia. The BOS posture, which is most striking in early childhood and often becomes less apparent with age, is characterized by flexion at the elbows with ulnar deviation and flexion of the wrists and metacarpophalangeal joints. Feeding difficulties in early childhood, including cyclic vomiting, have a significant impact on overall health; feeding tends to improve with age. Seizures are common and typically responsive to standard epileptic medications. Minor cardiac anomalies and transient bradycardia and apnea may be present. Affected individuals may experience recurrent infections, which also tend to improve with age. Isolated case reports suggest that individuals with BOS are at greater risk for Wilms tumor than the general population, but large-scale epidemiologic studies have not been conducted.
- Impact of non-apnea sleep disorders on diabetic control and metabolic outcome - A population-based cohort study. [Journal Article]
- GHGen Hosp Psychiatry 2018 Jan 31; 52:1-7
- CONCLUSIONS: Our findings indicated patients with type 2 diabetes comorbid with NSD had a slower improvement in HbA1c compared with the comparison cohort. It may because there may exist potential floor effect given those with NSD having significantly lower HbA1c values at baseline. On the other hand, the poor diabetic control among those with NSD may be also affected by other confounders such as medical treatment or interventions. Nevertheless, given the rapidly increasing prevalence of metabolic diseases and subsequent complications, the results may highlight the importance of sleep in the clinical management of type 2 diabetes.
- Correlations between pediatric obstructive sleep apnea and longitudinal growth. [Journal Article]
- IJInt J Pediatr Otorhinolaryngol 2018; 106:41-45
- CONCLUSIONS: Respiratory related results and oxygen saturation results of polysomnography show negative and positive correlation with z-score for height. Therefore, pediatric obstructive sleep apnea have a negative effect on longitudinal growth.
- Lingual tonsillectomy in children with Down syndrome: Is it safe? [Journal Article]
- IJInt J Pediatr Otorhinolaryngol 2018; 105:52-55
- CONCLUSIONS: LT has a favorable post-operative course but its effectiveness at curing rOSA in the DS population has not been established/proven. Further research is indicated to determine optimal surgical management for DS children with LTH.
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- Pre- and post-operative evaluation of the frequency of nocturnal enuresis and Modified Pediatric Epworth Scale in pediatric obstructive sleep apnea patients. [Journal Article]
- IJInt J Pediatr Otorhinolaryngol 2018; 105:36-39
- CONCLUSIONS: There is a strong correlation between OSA and NE. In the present study, enuresis in pediatric OSA patients significantly decreased after surgery. Also, Epworth scores decreased significantly after surgery. In children with nocturnal enuresis, the presence of OSA symptoms should be questioned.