- Biomechanical effect of mandibular advancement device with different protrusion positions for treatment of obstructive sleep apnea on tooth and facial bone: A finite element study. [Journal Article]
- JOJ Oral Rehabil 2018 Aug 20
- CONCLUSIONS: Mandibular advancement at 70% of maximum protrusion induces risks of tooth root resorption and bone resorption. The mandibular second molars were subjected to the highest stresses. Stress on the teeth and facial bones was the lowest at 40% of maximum mandibular advancement. This article is protected by copyright. All rights reserved.
- Treatment of obstructive sleep apnoea as primary or secondary prevention of cardiovascular disease: where do we stand now? [Journal Article]
- COCurr Opin Pulm Med 2018 Aug 18
- CONCLUSIONS: OSA may predispose to cardiovascular disease, but additional efforts for improving CPAP use or development of new treatments may help to understand the magnitude of OSA on cardiovascular disease.
- Obstructive Sleep Apnea: From Intermittent Hypoxia to Cardiovascular Complications via Blood Platelets. [Review]
- FNFront Neurol 2018; 9:635
- Obstructive sleep apnea is a chronic condition characterized by recurrent episodes of apneas or hypopneas during sleep leading to intermittent hypoxemia and arousals. The prevalence of the sleep diso...
Obstructive sleep apnea is a chronic condition characterized by recurrent episodes of apneas or hypopneas during sleep leading to intermittent hypoxemia and arousals. The prevalence of the sleep disordered breathing is estimated that almost 50% of men and 24% of women suffer from moderate to severe form of the disorder. Snoring, collapse of upper airways and intermittent hypoxia are main causes of smoldering systemic inflammation in patients suffering from obstructive sleep apnea. The systematic inflammation is considered one of the key mechanisms leading to significant cardiovascular complications. Blood platelets, formerly not even recognized as cells, are currently gaining attention as crucial players in the immune continuum. Platelet surface is endowed with receptors characteristic for cells classically belonging to the immune system, which enables them to recognize pathogens, immune complexes, and interact in a homo- and heterotypic aggregates. Platelets participate in the process of transcellular production of bioactive lipids by delivering both specific enzymes and substrate molecules. Despite their lack of nucleus, platelets synthetize proteins in a stimuli-dependent manner. Atherosclerosis and consequent cardiovascular complications result from disruption in homeostasis of both of the platelet roles: blood coagulation and inflammatory processes modulation. Platelet parameters, routinely evaluated as a part of complete blood count test, were proposed as markers of cardiovascular comorbidity in patients with obstructive sleep apnea. Platelets were found to be excessively activated in this group of patients, especially in obese subjects. Persistent activation results in enhanced spontaneous aggregability and change in cytokine production. Platelet-lymphocyte ratio was suggested as an independent marker for cardiovascular disease in obstructive sleep apnea syndrome and continuous positive air pressure therapy was found to have an impact on platelet parameters and phenotype. In this literature review we summarize the current knowledge on the subject of platelets involvement in obstructive sleep apnea syndrome and consider the possible pathways in which they contribute to cardiovascular comorbidity.
- The Epidemiology of Sleep and Diabetes. [Review]
- CDCurr Diab Rep 2018 Aug 17; 18(10):82
- To provide an overview of the mechanistic and epidemiologic evidence linking sleep-related exposures, such as short sleep duration, obstructive sleep apnea, shift work, and insomnia, with type 2 diab...
To provide an overview of the mechanistic and epidemiologic evidence linking sleep-related exposures, such as short sleep duration, obstructive sleep apnea, shift work, and insomnia, with type 2 diabetes risk in adults.
- Insulin resistance is associated with Sfrp5 in obstructive sleep apnea. [Journal Article]
- BJBraz J Otorhinolaryngol 2018 Aug 04
- CONCLUSIONS: Secreted frizzled-related protein 5 was involved in obstructive sleep apnea and the decrease in secreted frizzled-related protein 5 was directly proportional to the severity of obstructive sleep apnea. There was an independent negative correlation between homeostasis model assessment of insulin resistance and secreted frizzled-related protein 5 in the obstructive sleep apnea group. Secreted frizzled-related protein 5 might be a therapeutic target for insulin resistance in obstructive sleep apnea.
- Evaluation of Sexual Dysfunction, Lower Urinary Tract Symptoms and Quality of Life in Men with Obstructive Sleep Apnea Syndrome and The Efficacy of Continuous Positive Airway Pressure Therapy. [Journal Article]
- UUrology 2018 Aug 14
- CONCLUSIONS: In patient with OSAS, the severity of SD and LUTS and their effect on QOL differ according to the severity of OSAS and CPAP treatment improves the negative impact of these conditions on QOL.
- Apnea-Hypopnea Index in Healthy Class III Patients Treated With Intraoral Vertical Ramus Osteotomy: A Prospective Cohort Study. [Journal Article]
- JOJ Oral Maxillofac Surg 2018 Jul 24
- CONCLUSIONS: Mandibular setback surgery with the IVRO procedure in the range of 2.5 to 7.4 mm did not induce obstructive sleep apnea, measured as an AHI above 5 events per hour, in the 8 healthy, young adult Class III patients presented in this study. More studies including larger patient samples are needed.
- Prediction of obstructive sleep apnea using facial landmarks. [Journal Article]
- PMPhysiol Meas 2018 Aug 17
- Collapsibility of the upper airway has a known anatomical basis that is mediated by an interaction of obesity and craniofacial abnormalities. The pattern of these abnormalities, if detected in a subj...
Collapsibility of the upper airway has a known anatomical basis that is mediated by an interaction of obesity and craniofacial abnormalities. The pattern of these abnormalities, if detected in a subject's facial image, can help predict the presence of obstructive sleep apnea (OSA). We utilized facial photographs (front and profile) from 376 patients who had undergone an overnight polysomnogram to identify those with and without OSA. Processing the images had 3 steps: landmark identification, feature generation, and automatic classification. Firstly, we used unaligned landmarks and investigated the impact of manually and automatically determined landmarks on the performance of the classification algorithms. Using a feature set calculated from manually determined landmarks ("constrained features") we obtained 67.0% accuracy in identifying OSA (AHI>10) and using automatically determined landmarks we obtained 65.5% accuracy for OSA. Secondly, we aligned the facial landmark coordinates by using an image registration technique utilising linear transformations. Directly using the aligned landmark coordinates ('unconstrained features') by the classification stage as the new feature set resulted in an accuracy of 69.7% in OSA detection using manually determined landmarks and 69.2% using automatically determined landmarks. The performance of our fully automatic system using the unconstrained feature set is comparable to other published systems requiring a manual landmarking process. In conclusion, we demonstrate the feasibility of using automatic landmarking as well as unconstrained features in the successful prediction of OSA using facial landmarks.
- Total improvement after surgery for obstructive sleep apnea syndrome in a patient with concurrent malignant idiopathic intracranial hypertension. [Journal Article]
- JNJ Neurosurg 2018 Aug 17; :1-5
- The association between idiopathic intracranial hypertension (IIH) and obstructive sleep apnea syndrome (OSAS) constitutes an interesting point of discussion regarding clinical approaches as well as ...
The association between idiopathic intracranial hypertension (IIH) and obstructive sleep apnea syndrome (OSAS) constitutes an interesting point of discussion regarding clinical approaches as well as the underlying pathophysiological mechanisms. Here, the case of a 42-year-old female with malignant IIH and OSAS is illustrated. Initially, the patient was treated with lumboperitoneal shunt surgery. However, OSAS surgery provided total recovery from the recurrent symptoms developing secondary to lumboperitoneal shunt malfunction. The authors point out the importance of identifying OSAS as a crucial causative agent in some IIH subtypes. Future studies are warranted to clarify this underestimated association.
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- Undiagnosed Obstructive Sleep Apnoea and Physical Activity in Older Manual Workers. [Journal Article]
- JAJ Aging Phys Act 2018 Aug 17; :1-25
- Cardiovascular disease (CVD) is a negative health outcome of Obstructive Sleep Apnoea (OSA). Risk factors associated with OSA development include low physical activity (PA), high body mass index (BMI...
Cardiovascular disease (CVD) is a negative health outcome of Obstructive Sleep Apnoea (OSA). Risk factors associated with OSA development include low physical activity (PA), high body mass index (BMI), and increasing age (>50 years) and weight loss is usually recommended as treatment. This cross-sectional study examined the association between PA, BMI and OSA severity in manual workers. Fifty-five participants, (23 females, 32 males) mean age 55.2, were examined for OSA and completed a PA and anthropometric assessment. On average, OSA severity was mild, PA levels were moderate and 32% of the sample was classified as obese. PA was negatively associated with OSA severity, but BMI strongly independently predicted OSA severity, with no evidence of mediation. As both PA and BMI were significantly associated with OSA in older manual workers, increasing PA should also be a focus of treatment for OSA.