- Upper Airway Stimulation in Patients with Obstructive Sleep Apnea: Long-Term Surgical Success, Respiratory Outcomes, and Patient Experience. [Journal Article]Int Arch Otorhinolaryngol. 2023 Jan; 27(1):e43-e49.IA
- Introduction Upper airway stimulation (UAS) with electric activation of the hypoglossal nerve has emerged as a promising treatment for patients with moderate-to-severe obstructive sleep apnea. Objective To retrospectively analyze objective and subjective outcome measures after long-term follow-up in obstructive sleep apnea patients receiving upper airway stimulation. Methods An observational r…
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- Orbital Defect and Emphysema After Nose Blowing: A Case Report and Literature Review. [Case Reports]Cureus. 2022 Dec; 14(12):e32958.C
- A 59-year-old man with a history of obstructive sleep apnea presented to the emergency department for acute swelling of the left upper and lower eyelids after nose blowing. The patient denied prior orbital trauma or surgery and examinations were unremarkable for bony step-offs, lacerations, enophthalmos, proptosis, hypoglobus, or extraocular muscle restriction. Imaging confirmed the diagnosis of …
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- Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea. [Journal Article]Front Pharmacol. 2022; 13:1081345.FP
- Background: Patients with obstructive sleep apnea (OSA) experience recurrent hypoxemic events with a frequency sometimes exceeding 60 events/h. These episodic events induce downstream transient hypoxia in the parenchymal tissue of all organs, thereby eliciting the pathological consequences of OSA. Whereas experimental models currently apply intermittent hypoxia to cells conventionally cultured in…
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- Metabolic dysregulation and decreased capillarization in skeletal muscles of male adolescent offspring rats exposed to gestational intermittent hypoxia. [Journal Article]Front Physiol. 2023; 14:1067683.FP
- Gestational intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea that occurs frequently during pregnancy, and effects caused by this environmental change during pregnancy may be transmitted to the offspring. In this study, we aimed to clarify the effects of IH in pregnant rats on the skeletal muscle of adolescent offspring rats. Mother rats underwent IH from gestation day 7-21, and …
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- Veterans Health Administration TeleSleep Enterprise-Wide Initiative 2017-2020: bringing sleep care to our nation's veterans. [Journal Article]J Clin Sleep Med. 2023 Jan 28 [Online ahead of print]JC
- CONCLUSIONS: The TeleSleep EWI successfully increased sleep care access for rural veterans, promoted adoption of virtual care services, and resulted in high patient satisfaction.
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- Dyslipidemia prevalence in non-obese non-diabetic patients with obstructive sleep apnea: does sex matter? [Journal Article]J Clin Sleep Med. 2023 Jan 28 [Online ahead of print]JC
- CONCLUSIONS: After excluding confounding obesity and diabetes, patients with OSA have impaired lipid profile including total cholesterol, LDL-cholesterol, non-HDL-cholesterol, and triglycerides. A significant association between dyslipidemia and OSA severity was observed in women but not men.
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- Moderate-to-severe obstructive sleep apnea syndrome is associated with altered tongue motion during wakefulness. [Journal Article]Eur Arch Otorhinolaryngol. 2023 Jan 28 [Online ahead of print]EA
- CONCLUSIONS: Myofunctional activity of the tongue is impaired during wakefulness in non- or mildly obese patients with moderate-to-severe OSAS. This study supports the lingual myofunctional assessment using the MBLF in screening of moderate-to-severe OSAS. This simple tool could help clinicians to select patients with suspected moderate-to-severe OSAS for polysomnography.
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- PATIENT-REPORTED OUTCOMES WHILE MANAGING OBSTRUCTIVE SLEEP APNEA WITH ORAL APPLIANCES: A SCOPING REVIEW. [Review]J Evid Based Dent Pract. 2023 Jan; 23(1S):101786.JE
- CONCLUSIONS: This scoping review suggests that dPROs are mostly investigated as a secondary outcome from major studies exploring the effects of OAs on OSA severity, and often, dPROs are not well discussed or displayed on their report. As no risk of bias or certainty level assessment was completed, findings need to be carefully considered. Although in general terms management with OAs among adults with OSA does not seem to be uncomfortable or causing major problems to their lives, some mild discomfort and endured occlusal disturbances was reported in some studies. QoL seems to improve but consistent agreement was elusive. Data does not include experiences among those that dropped OA use. No data seems to exist about dPROs in children.
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- Association between Positive Airway Pressure Adherence and Healthcare Costs among Individuals with Obstructive Sleep Apnea. [Journal Article]Chest. 2023 Jan 24 [Online ahead of print]Chest
- CONCLUSIONS: In participants with OSA, better PAP adherence was associated with significantly lower healthcare costs over three years. Findings support the importance of strategies to enhance long-term PAP adherence.
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- Smart Devices are Poised to Revolutionize the Usefulness of Respiratory Sounds. [Review]Chest. 2023 Jan 24 [Online ahead of print]Chest
- The association between breathing sounds with respiratory health or disease has been exceptionally useful in the practice of medicine since the advent of the stethoscope. TOPIC IMPORTANCE: Remote patient monitoring technology and artificial intelligence offer the potential to develop practical means of assessing respiratory function or dysfunction through continuous assessment of breathing sounds…
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- Pediatric sleep apnea: Characterization of apneic events and sleep stages using heart rate variability. [Journal Article]Comput Biol Med. 2023 Jan 15; 154:106549.CB
- Heart rate variability (HRV) is modulated by sleep stages and apneic events. Previous studies in children compared classical HRV parameters during sleep stages between obstructive sleep apnea (OSA) and controls. However, HRV-based characterization incorporating both sleep stages and apneic events has not been conducted. Furthermore, recently proposed novel HRV OSA-specific parameters have not bee…
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- Clinical phenotype of obstructive sleep apnea in older adults: a hospital-based retrospective study in China. [Journal Article]Ir J Med Sci. 2023 Jan 27 [Online ahead of print]IJ
- CONCLUSIONS: The presence of OSA in older adults was associated with significant abnormalities of sleep architecture, aggravated nocturnal hypoxia and increased risks of hypertension, CAD, and stroke, which can be distinguished as a unique clinical phenotype.
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- Should Mandibular Symphyseal Distraction Osteogenesis be considered in OSA Surgery? [Journal Article]Orthod Fr. 2022 Dec 01; 93(Suppl 1):91-95.OF
- CONCLUSIONS: The goal of surgical maxillary expansion is to enlarge the nasal cavity and reduce the airway resistance. CFD data demonstrates that EASE results in a much greater reduction in airway resistance as compared to DOME. EASE achieved a 12-fold reduction in nasal airway resistance compared to 3-fold reduction by DOME; a 12-fold reduction of retropalatal airway resistance as compared to 3-fold reduction by DOME; a 10-fold reduction of oropharyngeal airway resistance as compared to a 3-fold reduction by DOME, and an 8-fold reduction of hypopharygeal airway resistance as compared to a 3-fold reduction by DOME. Because there is no physiologic basis or data that demonstrates mandibular widening improves OSA, an airway centric surgical expansion technique such as EASE can achieve a much greater airway impact without needing excessive maxillary widening, thus eliminating the necessity MSDO.
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- Maxillomandibular Advancement for OSA: A 25-year perspective. [Journal Article]Orthod Fr. 2022 Dec 01; 93(Suppl 1):97-108.OF
- CONCLUSIONS: MMA is an effective treatment to improve OSA, but the result can vary. Patient selection based on favorable prognostic factors and maximizing the advancement distance can improve outcomes.
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- Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li. [Journal Article]Orthod Fr. 2022 Dec 01; 93(Suppl 1):5-33.OF
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- Maxillomandibular Advancement for OSA: Serious Complications and Failures. [Journal Article]Orthod Fr. 2022 Dec 01; 93(Suppl 1):61-73.OF
- CONCLUSIONS: Although MMA is typically a predictable operation with excellent outcomes, failure of improvement and severe long-term sequelae from surgical complications are possible. Surgical precision with sufficient skeletal advancement for airway improvement and stable skeletal fixation is necessary to achieve a successful outcome.
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- Surgical and non-surgical maxillary expansion: expansion patterns, complications and failures. [Journal Article]Orthod Fr. 2022 Dec 01; 93(Suppl 1):35-46.OF
- CONCLUSIONS: Different maxillary expansion methods are currently being performed with varying outcomes. Critical analyses of these methods are needed to determine their impact and whether the desired outcomes are achieved.
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- Persistent pediatric obstructive sleep apnea treated with skeletally anchored transpalatal distraction. [Journal Article]Orthod Fr. 2022 Dec 01; 93(Suppl 1):47-60.OF
- CONCLUSIONS: Nasomaxillary expansion by skeletally anchored TPD improves OSA in children without transverse maxillary deficiency that were previously treated by RPE. A nearly parallel anterior-posterior opening of the mid-palatal suture achieves enlargement of the entire nasal passage with improvement of the airflow characteristics in the nasal and pharyngeal airway. The improved airflow characteristic is significantly correlated with the improved polysomnographic findings, thus demonstrating that nasomaxillary expansion in previously expanded patients is a viable treatment option.
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- Central Sleep Apnea Detection by Means of Finger Photoplethysmography. [Journal Article]
- CONCLUSIONS: The present study aimed to evaluate a method to detect CSA in SA patients using only PPG data which could be used to flag CSA which in turn may aid in more optimal therapy decision making.
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- Application of drug-induced sleep endoscopy in predicting the outcomes of velopharyngeal surgery in adult patients with Friedman stage II and III obstructive sleep apnea syndrome. [Journal Article]
- CONCLUSIONS: The VA-CP and GA-CD in DISE examination are valuable for predicting the treatment outcomes of velopharyngeal surgery in patients with Friedman stage II and III OSAS. Patients with lateral VA-CP and grade I GA-CD are appropriate candidates for velopharyngeal surgery.
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- Positive end-expiratory pressure in chronic care of children with obstructive sleep apnoea. [Review]Paediatr Respir Rev. 2023 Jan 11 [Online ahead of print]PR
- Positive end-expiratory pressure (PEEP) consists of the delivery of a constant positive pressure in the airways by means of a noninvasive interface aiming to maintain airway patency throughout the entire respiratory cycle. PEEP is increasingly used in the chronic care of children with anatomical or functional abnormalities of the upper airways to correct severe persistent obstructive sleep apnea …
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- The effect of OSA on the negative pressure and acoustic compliance of middle ear cavity in children. [Journal Article]Int J Pediatr Otorhinolaryngol. 2023 Jan 20; 165:111457.IJ
- CONCLUSIONS: OSA may have an adverse influence on the negative pressure and acoustic compliance of middle ear cavity in children.
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- What Is Snoring? [Journal Article]JAMA Otolaryngol Head Neck Surg. 2023 Jan 26 [Online ahead of print]JO
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- Prevalence of Obstructive Sleep Apnea With Floppy Eyelid Syndrome: A Systematic Review and Meta-analysis. [Journal Article]Ophthalmic Plast Reconstr Surg. 2022 Oct 28 [Online ahead of print]OP
- CONCLUSIONS: This meta-analysis demonstrates OSA is a common comorbidity in the FES population. Ophthalmologists are often the first to evaluate patients with FES, and considering this coincidence, routine screens for sleep apnea symptoms in at-risk FES patients should be undertaken. Large case-control studies are required to better elucidate the exact prevalence of OSA and other morbidities in patients with FES, and to better understand the etiology of FES.
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- Recognition and Management of Obstructive Sleep Apnea in Psychiatric Practice. [Journal Article]J Clin Psychiatry. 2023 Jan 23; 84(2)JC
- Objective: The aims of this review were to describe the relationship between obstructive sleep apnea (OSA) and psychiatric disorders and provide an overview of how to recognize/manage OSA in psychiatric practice.
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- Clinical-functional characteristics of children with asthma and obstructive sleep apnea overlap associated with attention deficit hyperactivity disorder: A cross-sectional study. [Journal Article]Front Neurol. 2022; 13:1097202.FN
- CONCLUSIONS: The prevalence of OSA is increased among poorly controlled asthma. ADHD may have a higher prevalence in children with OSA. Therefore, prompt diagnosis of OSA will lead to an accurate asthma control strategy in patients with asthma.
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- The Use of Continuous Positive Airway Pressure for Patients With Obstructive Sleep Apnea is Associated With Early Medical and Surgery-Related Complications Following Total Knee Arthroplasty: A National Database Study. [Journal Article]Arthroplast Today. 2023 Feb; 19:101085.AT
- CONCLUSIONS: OSA patients on CPAP undergoing TKA have significantly increased complication rates compared to OSA patients not using CPAP.
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- The influence of mouth opening on pharyngeal pressure loss and its underlying mechanism: A computational fluid dynamic analysis. [Journal Article]Front Bioeng Biotechnol. 2022; 10:1081465.FB
- Objective: During inspiration, mechanical energy generated from respiratory muscle produces a negative pressure gradient to fulfill enough pulmonary ventilation. The pressure loss, a surrogate for energy loss, is considered as the portion of negative pressure without converting into the kinetic energy of airflow. Mouth opening (MO) during sleep is a common symptom in patients with obstructive sle…
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- Diagnosis of obstructive sleep apnea using a bio-radar contact-free system compared with an established HST device in older adults. [Journal Article]Sleep Health. 2023 Jan 23 [Online ahead of print]SH
- CONCLUSIONS: The bio-radar sleep monitoring device is a reasonably accurate home sleep apnea test for use in older patients.
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- Obstructive sleep apnea-hypopnea syndrome and liver fibrosis. [Journal Article]Minerva Med. 2022 Dec; 113(6):1027.MM
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