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Unbound Medicine.
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2,886 results
  • Continuation of psychiatric medications during pregnancy. [Journal Article]
    J Matern Fetal Neonatal Med. 2023 Dec; 36(1):2171288.Logue TC, Wen T, … Friedman AM
  • Background: While medications for anxiety and depression are commonly used in the United States, it is unclear to what degree they are continued during pregnancy.Methods: We used a large administrative database to determine whether psychiatric medications are continued during pregnancy and predictors of continued medication treatment.Results: Of 2,672,656 women included in our analysis, 86,454 (3…
  • Part I: Missouri's Fentanyl Poisonings Rise to Record Levels. [Review]
    Mo Med. 2022 Nov-Dec; 119(6):489-493.Stoecker WV, Smith CL, Connors E
  • Missourians are dying of fentanyl poisoning at an unprecedented rate. We identified growth areas in Missouri for fatal fentanyl encounters in rural and western counties. Though the deaths occur for a multitude of reasons, a growing trend adds to the surge in fentanyl fatalities: poisonings from counterfeit pills. The tablets are often labeled with brand names for alprazolam or oxycodone, but may …
  • Changes in Alprazolam Metabolism by CYP3A43 Mutants. [Journal Article]
    Biomedicines. 2022 Nov 23; 10(12)Zhao J, Liu S, … Bureik M
  • Alprazolam is a triazolobenzodiazepine which is most commonly used in the short-term management of anxiety disorders, often in combination with antipsychotics. The four human members of the CYP3A subfamily are mainly responsible for its metabolism, which yields the main metabolites 4-hydroxyalprazolam and α-hydroxyalprazolam. We performed a comparison of alprazolam metabolism by all four CYP3A en…
  • Static magnetic field blocked alprazolam-induced behavior of Wistar rats in the elevated plus-maze test. [Journal Article]
    Neurosci Lett. 2023 01 18; 794:137013.Brito RC, Olivato T, … de Araujo JE
  • Studies have shown that psychotropic drugs change rat behavior in the elevated plus-maze test (EPM). This study investigated whether static magnetic fields could alter alprazolam-induced rat behavior in the EPM. 66 male Wistar rats (270-300 g weight) were assigned to one of the following groups: Sham Magnetic + Saline (SMS), North Pole + Saline (NPS), South Pole + Saline (SPS), Sham magnetic + al…
  • Recent advances in the detection of drugs of abuse by dried blood spots. [Review]
    Biomed Chromatogr. 2022 Nov 23 [Online ahead of print]Ververi C, Vincenti M, Salomone A
  • The purpose of this review study was to sum up the main recent advances reported in the scientific literature about the detection of common drugs of abuse in biological samples upon their collection by dried blood spot devices. The most recent, innovative and fully validated methods for the qualitative and/or quantitative detection of common drugs of abuse are reported, including alprazolam, clon…
  • Bitten to the Bone: A Case of Anxiety-Induced Osteomyelitis. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31511.Rivera JA, Aragon D, … Hernandez D
  • Onychophagia is a habitual nail-biting disorder, usually associated with mental or emotional diseases. It affects 20-30% of the population in all age groups. Human bites have the potential to become serious injuries due to high virulence in the human oral flora and may often require hospital admission, antibiotics and even debridement in the operating room. Thus, repetitive nail biting has the po…
  • Management of Somatization in COVID-19: A Narrative Review. [Review]
    Cureus. 2022 Oct; 14(10):e30262.Wankhade D, Anjankar AP
  • Somatization refers to the condition in which psychological distress is shown in the form of somatic symptoms such as persistent headache, nausea, gastrointestinal discomfort, etc. Various predisposing factors, including familial such as high expressed emotion, poor parental care, genetic, biological, and demographic which includes age and gender, cognitive such as learning disabilities, psychiat…
  • Alprazolam Detection Using an Electrochemical Nanobiosensor Based on AuNUs/Fe-Ni@rGO Nanocomposite. [Journal Article]
    Biosensors (Basel). 2022 Oct 31; 12(11)Sadrabadi EA, Khosravi F, … Azimzadeh M
  • Despite all the psychological advantages of alprazolam, its long list of toxic properties and interactions has caused concern and highlighted the need for a reliable sensing method. In this study, we developed a simple, highly sensitive electrochemical nanobiosensor to determine the desirable dose of alprazolam, averting the undesirable consequences of overdose. Gold nanourchins (AuNUs) and iron-…
  • Clonazolam Intoxication Case Report: Danger of Designer Benzodiazepines. [Case Reports]
    Am J Forensic Med Pathol. 2022 Dec 01; 43(4):372-375.Moore C, Hammers J, Marshall P
  • Clonazolam is a derivative of the Xanax active ingredient, alprazolam. Classified as a designer benzodiazepine, clonazolam availability has been rising because of its circulation on illegal internet drug markets and marginal cost in comparison to its parent analogs. Clonazolam's accessibility encourages abuse prevalence and use of designer benzodiazepines. In our case, a 14-year-old male was foun…
  • Benzodiazepine use disorder: A cross-sectional study at a tertiary care center in Lebanon. [Journal Article]
    Medicine (Baltimore). 2022 Sep 23; 101(38):e30762.El Zahran T, Kanaan E, … Hitti E
  • Benzodiazepines are medications used for the treatment of multiple conditions including anxiety disorders, insomnia, agitation, and seizures. They are the most prescribed psychiatric medications and the third most misused drugs among adults and adolescents in the US. This study aims to assess the patient utilization patterns and benzodiazepine use disorder among Lebanese patients. A cross-section…
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