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Unbound Medicine.
(Apo Benztropine)
1,034 results
  • Benztropine and suicide attempts and intentional self-harm. [Journal Article]
    Psychiatry Res. 2023 Jan 07; 320:115054.Gibbons RD, Hur K, … Mann JJ
  • CONCLUSIONS: Benztropine was found to lower suicidal event rates, comparably in those receiving or not receiving antipsychotic medications, regardless of the presence of major psychiatric disorders. This observation warrants testing in a randomized clinical trial.
  • Case series profile of olanzapine post-injection delirium/sedation syndrome. [Journal Article]
    Br J Clin Pharmacol. 2023 Feb; 89(2):903-907.Seebaluck J, Downes MA, … Chan BS
  • Olanzapine pamoate is an intramuscular depot injection for the treatment of schizophrenia. Approximately 1.4% of patients develop a serious adverse event called post-injection delirium/sedation syndrome (PDSS), characterised by drowsiness, anticholinergic and extrapyramidal symptoms. The objective is to investigate olanzapine PDSS presentations including clinical features and treatment approach. …
  • StatPearls: Benztropine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)AhujaAbhimanyuACharles E. Schmidt College of MedicineAbdijadidSaraSUCLABOOK
  • Benztropine is FDA approved as adjunctive therapy for all forms of parkinsonism. It is also used for drug-induced extrapyramidal symptoms and the prevention of dystonic reactions as well as acute treatment of dystonic reactions. This activity examines the indications, mechanism of action, dosing, adverse event profile, and other factors so members of the interprofessional healthcare team can make…
  • Acute Dystonia With Rhabdomyolysis Induced by Paliperidone Palmitate: A Rare Adverse Effect. [Case Reports]
    Cureus. 2022 Sep; 14(9):e28771.Allena N, Doppalapudi S, … Nasr R
  • Antipsychotic medications have been well-established to potentially cause extrapyramidal side effects (EPS) including hyperkinesia, tremor, dyskinesia, dystonia, and parkinsonism. Rhabdomyolysis secondary to extrapyramidal symptoms in patients under antipsychotics is a relatively rare presentation to be observed in patients. In this report, we present a 64-year-old female with rhabdomyolysis foll…
  • Recognition and Treatment Challenges of Acute Clozapine Withdrawal Syndrome: A Case Report. [Case Reports]
    Cureus. 2022 Jun; 14(6):e25765.Metropulos JT, Goldstein BR, Hodapp B
  • The limited psychiatric bedspace due to the COVID-19 pandemic and the lack of access to an up-to-date medication regimen delayed the recognition of the diagnosis and treatment for a 40-year-old man with schizoaffective disorder, bipolar type, who traveled from his home city and abruptly discontinued his prescription of clozapine. He developed a cholinergic rebound syndrome including delirium and …
  • Anticholinergic treatment for sialorrhea in children: A systematic review. [Journal Article]
    Paediatr Child Health. 2022 May; 27(2):82-87.You P, Strychowsky J, … Chen BA
  • CONCLUSIONS: Glycopyrrolate, scopolamine/hyoscine, trihexyphenidyl/benzhexol, benztropine, and atropine have all shown efficacy in the treatment of sialorrhea in children. The small number of reports and the variability in study design precluded a meta-analysis. More studies are needed with uniformity in outcome measures to help guide evidence-based decision making. A guidance table is presented.
  • Oligodendroglia Generated From Adult Rat Adipose Tissue by Direct Cell Conversion. [Journal Article]
    Front Cell Dev Biol. 2022; 10:741499.Vellosillo L, Pascual-Guerra J, … Paíno CL
  • Obtaining oligodendroglial cells from dispensable tissues would be of great interest for autologous or immunocompatible cell replacement therapy in demyelinating diseases, as well as for studying myelin-related pathologies or testing therapeutic approaches in culture. We evaluated the feasibility of generating oligodendrocyte precursor cells (OPCs) from adult rat adipose tissue by expressing gene…
  • Misuse of Anticholinergic Medications: A Systematic Review. [Review]
    Biomedicines. 2022 Feb 01; 10(2)Chiappini S, Mosca A, … Di Giannantonio M
  • (1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, o…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Parkinson Disease Agents [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Parkinson disease is a progressive neurological condition characterized by slowness and paucity of movement (bradykinesia), muscle rigidity, resting tremors, and disordered posture. The onset is typically in the 6th or 7th decade of life with slow progression to akinesia, severe tremors, physical disability and death within 10 to 25 years of initial symptoms. Parkinson disease is common and affec…
  • Case report: asenapine and anticholinergic toxicity. [Case Reports]
    Int Clin Psychopharmacol. 2021 07 01; 36(4):214-217.Sheehan AK, Richards-Bentley C, … Rasimas JJ
  • While antipsychotic medications have long been associated with anticholinergic effects, asenapine has been purported to have no capacity for muscarinic cholinergic antagonism based on in vitro studies. Research in rat brain tissue has yielded different results, with one study finding more cholinergic M1-5 binding in the medial prefrontal cortex, dorsolateral frontal cortex and hippocampal CA1 and…
  • Unprovoked Dystonic Reaction in a Child Taking Long-Term Methylphenidate. [Case Reports]
    J Pharm Pract. 2022 Oct; 35(5):796-799.Pagliaro A, Mattio B, … Vidal J
  • In this report, we discuss the case of a 9-year-old male with Attention Deficit Hyperactivity Disorder (ADHD) on long-term methylphenidate and guanfacine who experienced acute orofacial dystonia that resolved immediately with the administration of benztropine. Current literature describes various cases of methylphenidate-induced dystonia, but ours appears to be the first reported instance of spon…
  • An Unlikely Case of Benztropine Misuse in an Elderly Schizophrenic. [Case Reports]
    Cureus. 2021 Feb 18; 13(2):e13434.Esang M, Person US, … Ahmadian D
  • Although data on the prevalence of anticholinergic misuse is scarce, it has been reported among psychiatric patients. Anticholinergic drugs can act as potent indirect dopamine agonists in the limbic system, a mechanism that has been hypothesized to explain their misuse potential among patients. In psychiatric practice settings, the use of typical antipsychotics in conjunction with anticholinergic…
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