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Unbound Medicine.
(Apo Carbamazepine)
9 results
  • Preparation of human drug metabolites using fungal peroxygenases. [Journal Article]
    Biochem Pharmacol. 2011 Oct 01; 82(7):789-96.Poraj-Kobielska M, Kinne M, … Hofrichter M
  • The synthesis of hydroxylated and O- or N-dealkylated human drug metabolites (HDMs) via selective monooxygenation remains a challenging task for synthetic organic chemists. Here we report that aromatic peroxygenases (APOs; EC 1.11.2.1) secreted by the agaric fungi Agrocybe aegerita and Coprinellus radians catalyzed the H₂O₂-dependent selective monooxygenation of diverse drugs, including acetanili…
  • Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine. [Journal Article]
    Xenobiotica. 2009 Feb; 39(2):140-7.Maekawa K, Yoshimura T, … Sawada J
  • 1. To assess the substrate-dependent effects of the low-activity allele of human CYP3A4, CYP3A4*16 (Thr185Ser), a recombinant wild-type (CYP3A4.1) or variant (CYP3A4.16) protein was co-expressed with human NADPH-P450 reductase in Sf21 insect cells using a baculovirus-insect cell system. 2. The holo-CYP3A4 protein level of CYP3A4.16 in insect microsomes was slightly higher than that of CYP3A4.1, w…
  • Serum lipid profile in children receiving anti-epileptic drug monotherapy: is it atherogenic? [Journal Article]
    J Pediatr Endocrinol Metab. 2006 Sep; 19(9):1151-5.Tekgul H, Demir N, Gokben S
  • The effect of anti-epileptic drugs (AEDs) on serum lipid profile is controversial in children as well as in adults. We longitudinally studied serum lipid profile in 34 newly diagnosed epileptic children receiving AED monotherapy with valproic acid (VPA), carbamazepine (CBZ) or phenobarbital (PB). Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lip…
  • The effects of long-term anticonvulsive treatment on serum lipid profile. [Journal Article]
    Acta Paediatr Jpn. 1997 Jun; 39(3):342-5.Yalçin E, Hassanzadeh A, Mawlud K
  • Serum lipids were determined in 10 untreated patients with recently diagnosed epilepsy, 21 patients treated with carbamazepine (CBZ), 10 patients treated with valproate (VPA) and in 15 healthy children. In relation to the controls, patients receiving CBZ showed increased serum high-density lipoprotein cholesterol (HDLc), apolipoprotein A (Apo-A) and apolipoprotein B (Apo-B). Patients receiving VP…
  • In vitro recovery of carbamazepine from ensure. [Journal Article]
    JPEN J Parenter Enteral Nutr. 1989 May-Jun; 13(3):272-6.Kassam RM, Friesen E, Locock RA
  • The in vitro recovery of three different dosage forms of carbamazepine (CBZ) when dispersed in gastric or intestinal fluids, in the presence or absence of Ensure was determined. An equivalent of 1 mg of pure CBZ from Tegretol 200 mg of conventional tablets, chewtablets of Tegretol 200-mg and Apo-carbamazepine (200-mg tablets) were dispersed in five dissolution mediums (0.5 ml of Ensure; 0.5 ml of…
  • Microsomal enzyme induction, lipoproteins and atherosclerosis. [Review]
    Pharmacol Toxicol. 1988 May; 62(5):243-9.Luoma PV
  • The liver is the principal site for the synthesis and elimination of lipoproteins circulating in plasma, and alterations in hepatic function influence plasma lipoprotein levels. High HDL-C/T-C and apo A-I/apo B ratios, which are characteristic of a low coronary risk, have been typical of healthy subjects with high microsomal enzyme activity in the liver. Microsomal enzyme inducing drugs such as p…
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