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Unbound Medicine.
(Apo Chlorpropamide)
2,095 results
  • StatPearls: Deadly Single Dose Agents [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EuwemaMichael S.MSOrange Park Medical CenterSwansonTerrell J.TJOrange Park Medical CenterBOOK
  • Although the basics of evaluating and treating most unknown ingestants are well known, many overdoses require very specific treatment if the patient is to have any chance of survival.[1] Countless studies have been published supporting Dr. Gideon Koren's 1993 landmark article "Medications Which Can Kill a Toddler with One Tablet or Teaspoonful" in the Journal of Toxicology.[2][3][4][5] while each…
  • Crystal structure of 4-bromo-N-(propyl-carbamo-yl)benzene-sulfonamide. [Journal Article]
    Acta Crystallogr E Crystallogr Commun. 2022 May 01; 78(Pt 5):485-489.Bookwala M, Patel S, … Wildfong PLD
  • The title compound, C10H13BrN2O3S, 1, contains a sulfonyl urea moiety, which possesses potential therapeutic functions (e.g., anti-diabetic and herbicidal). The geometry of 1 is similar to its closely related analogues, chlorpropamide and tolbutamide. This compound crystallizes in the monoclinic space group C2/c, having one mol-ecule in its asymmetric unit. The crystal structure of 1, recorded at…
  • Solids Turn into Liquids-Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility. [Journal Article]
    Pharmaceuticals (Basel). 2022 Feb 23; 15(3)Sarraguça MC, Ribeiro PRS, … Seabra CL
  • The low solubility of active pharmaceutical ingredients (APIs) is a problem in pharmaceutical development. Several methodologies can be used to improve API solubility, including the use of eutectic systems in which one of the constituents is the API. This class of compounds is commonly called Therapeutic Deep Eutectic Systems (THEDES). THEDES has been gaining attention due to their properties suc…
  • The Role of Vasopressin V2 Receptor in Drug-Induced Hyponatremia. [Review]
    Front Physiol. 2021; 12:797039.Kim S, Jo CH, Kim GH
  • Hyponatremia is frequently encountered in clinical practice and usually induced by renal water retention. Many medications are considered to be among the various causes of hyponatremia, because they either stimulate the release of arginine vasopressin (AVP) or potentiate its action in the kidney. Antidepressants, anticonvulsants, antipsychotics, diuretics, and cytotoxic agents are the major cause…
  • Diabeto-theranostics. [Journal Article]
    J Pak Med Assoc. 2020 Jan; 70(1):183-185.Kalra S, Gupta Y
  • This communication is an interesting and off-beat take on the concept of theranostics, as applied to diabetes care. It proposes the use of the term diabeto-theranostics, to define the combined use of diagnostic and therapeutic modalities, so as to create individualized or personalized treatment strategies in persons with diabetes. Historical examples such as the chlorpropamide challenge test and …
  • Sulfonylurea derivatives and cancer, friend or foe? [Journal Article]
    Eur J Pharmacol. 2019 Oct 15; 861:172598.Hendriks AM, Schrijnders D, … Landman GWD
  • Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to reduce cancer risk and progression, as has been demonstrated for the biguanide metformin in observation…
  • Drugs and Lactation Database (LactMed): Chlorpropamide [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Limited data indicate that amounts of chlorpropamide in breastmilk are unlikely to affect a breastfed infant. Short-acting drugs are generally preferred while breastfeeding a neonate to avoid drug accumulation. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of th…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Sulfonylureas [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The sulfonylureas are a class of agents that lower blood sugar as a result of increasing release of insulin from the pancreas. The sulfonylureas are used for the therapy of mild-to-moderate type 2 diabetes in conjunction with diet, and can be used alone or in combination with metformin, thiazolidinediones or other hypoglycemic agents. The sulfonylureas have been associated with rare cases of idio…
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