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(Apo Diflunisal)
753 results
  • Autonomic involvement in hereditary transthyretin amyloidosis (hATTR amyloidosis). [Review]
  • CAClin Auton Res 2018 Mar 06
  • Gonzalez-Duarte A
  • CONCLUSIONS: Autonomic nerves are often affected before motor nerve impairment, and dysautonomia may support the diagnosis of hATTR amyloidosis when differentiating from other adult-onset progressive neuropathies and from other types of amyloidosis. Most of the progression of autonomic dysfunction is seen in early stages of the disease, commonly before motor impairment or affection of the overall quality of life. Unfortunately, there is no current single standardized approach to evaluate dysautonomia in hATTR amyloidosis.
  • Diflunisal inhibits prestin by chloride-dependent mechanism. [Journal Article]
  • PlosPLoS One 2017; 12(8):e0183046
  • Duret G, Pereira FA, Raphael RM
  • The motor protein prestin is a member of the SLC26 family of anion antiporters and is essential to the electromotility of cochlear outer hair cells and for hearing. The only direct inhibitor of elect...
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