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Unbound Medicine.
(Apo Folic)
75 results
  • Methotrexate recognition by the human reduced folate carrier SLC19A1. [Journal Article]
    Nature. 2022 09; 609(7929):1056-1062.Wright NJ, Fedor JG, … Lee SY
  • Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division1,2. Mammals lack de novo folate synthesis pathways and thus rely on folate uptake from the extracellular milieu3. The human reduced folate carrier (hRFC, also known as SLC19A1) is the maj…
  • Interrogating preclinical study of liposomes: The effect of mouse strain reexamined. [Journal Article]
    J Control Release. 2021 06 10; 334:178-187.Guan J, Wu E, … Zhan C
  • Mice are arguably the most important tool in the preclinical evaluation of liposomes; however, the effects of inter-strain physiological variabilities on in vivo performance of liposomes have been seriously overlooked. The present study validated that plasma proteins (PPs) and the capability of mononuclear phagocyte system (MPS) (typically expressed by phagocytosis rate, K) were mice strain-depen…
  • Markers of obesity and growth in preeclamptic and normotensive pregnant women. [Journal Article]
    J Obstet Gynaecol. 2017 Jul; 37(5):610-615.Kharb S, Bala J, Nanda S
  • The objective of the study was to analyse leptin, IGF-1, Apo A, lipoproteins, haem oxygenase-1 (HO-1) in maternal sera and venous umbilical cord sera of newborn babies of 25 preeclamptics (group II), and 25 normotensive pregnant women (group I) as markers of obesity and growth in preeclamptic and normotensive pregnant women. Apo A I and II levels were estimated by competitive immunoassay using di…
  • Structural insight in the toppling mechanism of an energy-coupling factor transporter. [Journal Article]
    Nat Commun. 2016 Mar 30; 7:11072.Swier LJ, Guskov A, Slotboom DJ
  • Energy-coupling factor (ECF) transporters mediate uptake of micronutrients in prokaryotes. The transporters consist of an S-component that binds the transported substrate and an ECF module (EcfAA'T) that binds and hydrolyses ATP. The mechanism of transport is poorly understood but presumably involves an unusual step in which the membrane-embedded S-component topples over to carry the substrate ac…
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