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Unbound Medicine.
(Apo Haloperidol)
95 results
  • Predictive accuracy of CNN for cortical oscillatory activity in an acute rat model of parkinsonism. [Journal Article]
    Neural Netw. 2022 Feb; 146:334-340.Abdul Nabi Ali A, Alam M, … Schwabe K
  • In neurological and neuropsychiatric disorders neuronal oscillatory activity between basal ganglia and cortical circuits are altered, which may be useful as biomarker for adaptive deep brain stimulation. We investigated whether changes in the spectral power of oscillatory activity in the motor cortex (MCtx) and the sensorimotor cortex (SMCtx) of rats after injection of the dopamine (DA) receptor …
  • Atypical antipsychotic properties of AD-6048, a primary metabolite of blonanserin. [Journal Article]
    Pharmacol Biochem Behav. 2015 Nov; 138:14-9.Tatara A, Shimizu S, … Ohno Y
  • Blonanserin is a new atypical antipsychotic drug that shows high affinities to dopamine D2 and 5-HT2 receptors; however, the mechanisms underlying its atypicality are not fully understood. In this study, we evaluated the antipsychotic properties of AD-6048, a primary metabolite of blonanserin, to determine if it contributes to the atypicality of blonanserin. Subcutaneous administration of AD-6048…
  • Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models. [Journal Article]
    Pharmacol Rep. 2012; 64(1):191-204.Mahmood D, Khanam R, … Akhtar M
  • Schizophrenia (SCZ) afflicts around 1% of the world's population with characteristic symptoms such as hallucinations, delusions, and cognitive disorders. Several experimental studies in the past have indicted brain histaminergic neuronal system involvement in the pathogenesis of psychotic disorders including SCZ. Present study investigates anti-schizophrenic activity using two histamine H(3)-rece…
  • Antipsychotic-like properties of 5-alpha-reductase inhibitors. [Journal Article]
    Neuropsychopharmacology. 2008 Dec; 33(13):3146-56.Bortolato M, Frau R, … Gessa GL
  • Recent evidence indicates that neuroactive steroids may participate in the pathogenesis of schizophrenia spectrum disorders, yet the mechanisms of this involvement are elusive. As 5-alpha-reductase (5AR) is the rate-limiting enzyme of one of the two major metabolic pathways in brain steroidogenesis, we investigated the effects of its blockade in several rat models of psychotic-like behavior. The …
  • Delirium Tremens. [Journal Article]
    Med J Armed Forces India. 2004 Jan; 60(1):25-7.Mehta SR, Prabhu H, … Prasad D
  • The varied clinical manifestations and management of 14 male patients with delirium tremens (DT) have been studied. Eight patients were initially hospitalised for diseases unrelated to ethanol abuse i.e. 2 each for gun shot wound, myocardial infarction and stroke, and one each for pneumonia and gastroenteritis. One patient was going through withdrawal because of prodrome of viral hepatitis before…
  • Reproductive experience modulates dopamine-related behavioral responses. [Journal Article]
    Pharmacol Biochem Behav. 2001 Mar; 68(3):575-82.Hucke EE, Cruz-Casallas PE, … Felicio LF
  • Reproductive experience (RE), i.e., mating, pregnancy, parturition and lactation, has long-term physiological effects. It reduces the basal levels of circulating prolactin in parous women, decreases the intensity of nocturnal and diurnal prolactin surges in multigravid rats during early pregnancy, as well as the hormonal and neurochemical responses to the dopamine receptor antagonists metoclopram…
  • Behavioral characteristics of olanzapine: an atypical neuroleptic. [Journal Article]
    Acta Pharmacol Sin. 2000 Apr; 21(4):329-34.Fu Y, Zhu ZT, … Jin GZ
  • CONCLUSIONS: Ola distinguished itself from the typical neuroleptic (e.g. haloperidol, Hal) and took resemblance of the atypical neuroleptic (e.g. clozapine, Clo) in 3 aspects: 1) the multiple receptor pharmacodynamics involving D1/D2, 5-HT2 and M-ACh receptors; 2) dose-response separation between the block of conditioned avoidance response and catalepsy induction; and 3) the specificity of action sites of firing rates upon acute drug challenge.
  • Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. [Journal Article]
    Neurosci Res. 2000 Oct; 38(2) Bruin NM, van Luijtelaar EL, … Ellenbroek BA
  • Dopaminergic neurotransmission has been shown to participate in the control of absence epilepsy. This type of epilepsy, a generalized non-convulsive form, is associated with bursts of bilateral synchronous spike wave discharges (SWDs) recorded in the EEG. In a previous study, it was suggested that two features of the apomorphine-susceptible (APO-SUS) rat genotype, a relatively low dopaminergic re…
  • Low doses of apomorphine suppress operant motor performance in rats. [Journal Article]
    Pharmacol Biochem Behav. 1996 Feb; 53(2):335-40.Liu X, Strecker RE, Brener JM
  • The purpose of this study was to examine the effects of low doses of apomorphine on motor performance. Six rats were rewarded with sugar water on a partial reinforcement schedule for pressing force-sensitive beams with a minimum force of 1 g. The kinetics of individual responses and the temporal characteristics of response sequences were measured; open field locomotor activity was also measured i…
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