Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Apo Hydro)
40 results
  • Drugs and Lactation Database (LactMed): Furosemide [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because little information is available on the use of furosemide during breastfeeding and because intense diuresis from high doses might decrease lactation, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Low doses of furosemide (20 mg daily) do not suppress lactation.
  • Differential lysine-mediated allosteric regulation of plant dihydrodipicolinate synthase isoforms. [Journal Article]
    FEBS J. 2021 08; 288(16):4973-4986.Hall CJ, Lee M, … Soares da Costa TP
  • Lysine biosynthesis in plants occurs via the diaminopimelate pathway. The first committed and rate-limiting step of this pathway is catalysed by dihydrodipicolinate synthase (DHDPS), which is allosterically regulated by the end product, l-lysine (lysine). Given that lysine is a common nutritionally limiting amino acid in cereal crops, there has been much interest in probing the regulation of DHDP…
  • Metal chaperone, NhpC, involved in the metallocenter biosynthesis of nitrile hydratase. [Journal Article]
    J Gen Appl Microbiol. 2021 Apr 16; 67(1):24-32.Hashimoto Y, Ube Y, … Kobayashi M
  • Pseudomonas chlororaphis B23 yields nitrile hydratase (NHase) used for the production of 5-cyanovaleramide at the industrial level. Although the nhpC gene (known as P47K) located just downstream of the NHase structural genes (nhpAB) has been important for efficient NHase expression, the key role of nhpC remains poorly studied. Here, we purified two NHases expressed in the presence and absence of …
  • Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target. [Journal Article]
    Structure. 2018 07 03; 26(7):948-959.e5.Atkinson SC, Dogovski C, … Perugini MA
  • Protein dynamics manifested through structural flexibility play a central role in the function of biological molecules. Here we explore the substrate-mediated change in protein flexibility of an antibiotic target enzyme, Clostridium botulinum dihydrodipicolinate synthase. We demonstrate that the substrate, pyruvate, stabilizes the more active dimer-of-dimers or tetrameric form. Surprisingly, ther…
  • Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases. [Journal Article]
    J Mol Biol. 2017 05 19; 429(10):1554-1569.Faille A, Gavalda S, … Pedelacq JD
  • Dehydration reactions play a crucial role in the de novo biosynthesis of fatty acids and a wide range of pharmacologically active polyketide natural products with strong emphasis on human medicine. The type I polyketide synthase PpsC from Mycobacterium tuberculosis catalyzes key biosynthetic steps of lipid virulence factors phthiocerol dimycocerosates and phenolic glycolipids. Given the insolubil…
  • Crystal structure analysis of a fatty acid double-bond hydratase from Lactobacillus acidophilus. [Journal Article]
    Acta Crystallogr D Biol Crystallogr. 2013 Apr; 69(Pt 4):648-57.Volkov A, Khoshnevis S, … Feussner I
  • Bacteria have evolved mechanisms for the hydrogenation of unsaturated fatty acids. Hydroxy fatty acid formation may be the first step in such a process; however, knowledge of the structural and mechanistic aspects of this reaction is scarce. Recently, myosin cross-reactive antigen was shown to be a bacterial FAD-containing hydratase which acts on the 9Z and 12Z double bonds of C16 and C18 non-est…
  • Induction of DNA breakage in U937 cells by oxazaphosphorines. [Journal Article]
    Folia Biol (Krakow). 2010; 58(1-2):15-20.Mazur L, Opydo-Chanek M, … Niemeyer U
  • Oxazaphosphorines are a class of DNA alkylating agents. The aim of the present study was to compare the possible influence of three new generation oxazaphosphorines, D-17272 (mafosfamide cyclohexylamine salt), D-18864 (4-hydro-peroxy-cyclophosphamide), and D-19575 (glufosfamide, beta-D-glucose-isophosphoramide mustard) on DNA damage induction in the human histiocytic lymphoma U937 cells. The flow…
  • Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax. [Journal Article]
    J Biol Chem. 2010 Feb 19; 285(8):5188-95.Voss JE, Scally SW, … Perugini MA
  • Bacillus anthracis is a gram-positive spore-forming bacterium that causes anthrax. With the increased threat of anthrax in biowarfare, there is an urgent need to characterize new antimicrobial targets from B. anthracis. One such target is dihydrodipicolinate synthase (DHDPS), which catalyzes the committed step in the pathway yielding meso-diaminopimelate and lysine. In this study, we employed CD …
  • Structure and Function of [NiFe]-Hydrogenases. [Journal Article]
    Met Ions Life Sci. 2009; 6:151-78.Fontecilla-Camps JC
  • [NiFe(Se)]-hydrogenases are hetero-dimeric enzymes present in many microorganisms where they catalyze the oxidation of molecular hydrogen or the reduction of protons. Like the other two types of hydrogen-metabolizing enzymes, the [FeFe]- and [Fe]-hydrogenases, [NiFe]-hydrogenases have a Fe(CO)(x) unit in their active sites that is most likely involved in hydride binding. Because of their complexi…
  • Discovery of posttranslational maturation by self-subunit swapping. [Journal Article]
    Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):14849-54.Zhou Z, Hashimoto Y, … Kobayashi M
  • Several general mechanisms of metallocenter biosynthesis have been reported and reviewed, and in all cases, the components or subunits of an apoprotein remain in the final holoprotein. Here, we first discovered that one subunit of an apoenzyme did not remain in the functional holoenzyme. The cobalt-containing low-molecular-mass nitrile hydratase (L-NHase) of Rhodococcus rhodochrous J1 consists of…
New Search Next