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Unbound Medicine.
(Apo Ibuprofen)
9 results
  • Drugs and Lactation Database (LactMed): Ibuprofen [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because of its extremely low levels in breastmilk, short half-life and safe use in infants in doses much higher than those excreted in breastmilk, ibuprofen is a preferred choice as an analgesic or antiinflammatory agent in nursing mothers.
  • Imidazole-rich copper peptides as catalysts in xenobiotic degradation. [Journal Article]
    PLoS One. 2020; 15(11):e0238147.Begum SZ, Nizam NSM, … Abdul Rahman MB
  • Laccases, oxidative copper-enzymes found in fungi and bacteria were used as the basis in the design of nona- and tetrapeptides. Laccases are known to be excellent catalysts for the degradation of phenolic xenobiotic waste. However, since solvent extraction of laccases is environmentally-unfriendly and yields obtained are low, they are less preferred compared to synthetic catalysts. The histidine …
  • Toremifene interacts with and destabilizes the Ebola virus glycoprotein. [Journal Article]
    Nature. 2016 07 07; 535(7610):169-172.Zhao Y, Ren J, … Stuart DI
  • Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no approved therapeutic drugs or vaccines for the disease. EBOV has a membrane envelope decorated by trimers of a glycoprotein (GP, cleaved by furin to form GP1 and GP2 subunits), which is solely responsible for host cell attachment, endosomal …
  • Preparation of human drug metabolites using fungal peroxygenases. [Journal Article]
    Biochem Pharmacol. 2011 Oct 01; 82(7):789-96.Poraj-Kobielska M, Kinne M, … Hofrichter M
  • The synthesis of hydroxylated and O- or N-dealkylated human drug metabolites (HDMs) via selective monooxygenation remains a challenging task for synthetic organic chemists. Here we report that aromatic peroxygenases (APOs; EC secreted by the agaric fungi Agrocybe aegerita and Coprinellus radians catalyzed the H₂O₂-dependent selective monooxygenation of diverse drugs, including acetanili…
  • Cochlear Implant : Anaesthesia Challenges. [Journal Article]
    Med J Armed Forces India. 2004 Oct; 60(4):351-6.Chakrabarty A, Tarneja VK, … Sreevastava DK
  • Cochlear implants are now an acceptable therapeutic option for those patients with irreversible hearing loss and deaf-mutism. The surgery is time consuming and complicated. Hence, the technique of anaesthesia plays a crucial role in success of cochlear implant surgery. Cochlear implant patients have various types of syndromes which are important from anaesthetic as well as surgical point of view.…
  • Inhibitor-induced changes in the intrinsic fluorescence of human cyclooxygenase-2. [Journal Article]
    Biochemistry. 1996 Aug 20; 35(33):10974-84.Houtzager V, Ouellet M, … Percival MD
  • The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697. The effects of these inhibitors on tryptophan fluorescence are both time and concentration dependent. Addition of each inhibitor results in a rapid fluorescence decrease, followed by a slower tim…
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