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Unbound Medicine.
(Apo Indomethacin)
20 results
  • Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation. [Journal Article]
    Psychoneuroendocrinology. 2014 Jan; 39:204-213.Frau R, Bini V, … Bortolato M
  • Cogent evidence points to the involvement of neurosteroids in the regulation of dopamine (DA) neurotransmission and signaling, yet the neurobiological bases of this link remain poorly understood. We previously showed that inhibition of 5α-reductase (5αR), a key neurosteroidogenic enzyme, attenuates the sensorimotor gating deficits induced by DA receptor activation, as measured by the prepulse inh…
  • Effect of n-3 fatty acids on VLDL production by hepatocytes is mediated through prostaglandins. [Journal Article]
    Biochem Mol Biol Int. 1997 Dec; 43(5):1071-80.Anil K, Jayadeep A, Sudhakaran PR
  • The mechanism of the hypolipidemic effect of n-3 fatty acids was studied using isolated rat hepatocytes maintained in culture. EPA and DHA caused a significant reduction in the incorporation of 3[H]-leucine into apoB associated with the VLDL produced by hepatocytes in culture when compared to that in presence of palmitic acid. Presence of indomethacin, an inhibitor of cyclo-oxygenase reversed the…
  • Inhibitor-induced changes in the intrinsic fluorescence of human cyclooxygenase-2. [Journal Article]
    Biochemistry. 1996 Aug 20; 35(33):10974-84.Houtzager V, Ouellet M, … Percival MD
  • The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697. The effects of these inhibitors on tryptophan fluorescence are both time and concentration dependent. Addition of each inhibitor results in a rapid fluorescence decrease, followed by a slower tim…
  • In vitro and in vivo testing of hydralazine genotoxicity. [Journal Article]
    J Pharmacol Exp Ther. 1995 Apr; 273(1):113-20.Martelli A, Allavena A, … Brambilla G
  • Hydralazine (HDZ), a p.o. effective antihypertensive drug, was evaluated for its genotoxic effects in both rodent and human cultured cells and in the intact rat. Dose-dependent amounts of DNA fragmentation, as measured by the alkaline elution technique, and of DNA repair synthesis, as revealed by autoradiography, were produced in primary cultures of metabolically competent rat hepatocytes by subt…
  • Inactivation of prostaglandin endoperoxide synthase by acylating derivatives of indomethacin. [Journal Article]
    Biochemistry. 1993 Mar 16; 32(10):2710-6.Wells I, Marnett LJ
  • Derivatives of the potent antiinflammatory agent and cyclooxygenase inhibitor indomethacin were synthesized in which the carboxylic acid moiety was converted into reactive acylating agents. Indomethacin imidazole (indomethacin-IM) and indomethacin N-hydroxysuccinimide (indomethacin-NHS) inactivated both the cyclooxygenase and peroxidase activities when incubated with the apo form of purified pros…
  • Augmentation of human monocyte chemiluminescence by iron-saturated lactoferrin. [Journal Article]
    Int J Immunopharmacol. 1983; 5(4):359-64.Ito M, Bognacki J, … Hadden JW
  • The effect of Fe3+ bound lactoferrin (LF) on chemiluminescence (CL) generation in human monocytes in the presence and absence of opsonized zymosan was examined. Fe3+ bound LF (10(-6) or 10(-7) M) augmented the CL response in the presence but not the absence of zymosan. In contrast, Apo LF, Fe3+ bound transferrin and Fe3+ itself had no significant effect. It appears that the effect of LF on zymosa…
  • Prostaglandin inhibition of apomorphine-induced circling in mice. [Journal Article]
    Pharmacol Biochem Behav. 1982 Dec; 17(6):1233-7.Schwarz RD, Uretsky NJ, Bianchine JR
  • The effect of prostaglandins (PGs) on apomorphine (apo)-induced circling was examined in unilaterally lesioned mice. Intraventricularly injected PGD2, PGE2, and PGF2 alpha at a dose of 1.0 nmole/g all inhibited apo-induced circling. When injected directly into the striatum, these same PGs also inhibited circling in a dose range of 0.01-0.1 nmole/g, while the PGE2 metabolite, 13,14-dihydro-15-keto…
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