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Unbound Medicine.
(Apo Keto)
95 results
  • Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. [Journal Article]
    Nat Chem Biol. 2020 07; 16(7):783-790.Gilbert NC, Gerstmeier J, … Newcomer ME
  • Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane. Here, we contrast the structural and functional consequences of the binding of two natural product inhibitors of 5-LOX. The redox-type …
  • Thermal degradation kinetics of all-trans and cis-carotenoids in a light-induced model system. [Journal Article]
    Food Chem. 2018 Jan 15; 239:360-368.Xiao YD, Huang WY, … Yang QM
  • Thermal degradation kinetics of lutein, zeaxanthin, β-cryptoxanthin, β-carotene was studied at 25, 35, and 45°C in a model system. Qualitative and quantitative analyses of all-trans- and cis-carotenoids were conducted using HPLC-DAD-MS technologies. Kinetic and thermodynamic parameters were calculated by non-linear regression. A total of 29 geometrical isomers and four oxidation products were det…
  • Structure-Based Engineering of an Artificially Generated NADP+-Dependent d-Amino Acid Dehydrogenase. [Journal Article]
    Appl Environ Microbiol. 2017 06 01; 83(11)Hayashi J, Seto T, … Sakuraba H
  • A stable NADP+-dependent d-amino acid dehydrogenase (DAADH) was recently created from Ureibacillus thermosphaericusmeso-diaminopimelate dehydrogenase through site-directed mutagenesis. To produce a novel DAADH mutant with different substrate specificity, the crystal structure of apo-DAADH was determined at a resolution of 1.78 Å, and the amino acid residues responsible for the substrate specifici…
  • B-factor Analysis and Conformational Rearrangement of Aldose Reductase. [Journal Article]
    Curr Proteomics. 2014; 11(3):151-160.Balendiran GK, Pandian JR, … Cascio D
  • The NADPH-dependent reduction of glucose reaction that is catalyzed by Aldose Reductase (AR) follows a sequential ordered kinetic mechanism in which the co-factor NADPH binds to the enzyme prior to the aldehyde substrate. The kinetic/structural experiments have found a conformational change involving a hinge-like movement of a surface loop (residues 213-224) which is anticipated to take place upo…
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