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Unbound Medicine.
(Apo Methyldopa)
7,176 results
  • A Comprehensive Review on Postpartum Depression. [Review]
    Cureus. 2022 Dec; 14(12):e32745.Suryawanshi O, Pajai S
  • One of the most common psychological effects following childbirth is postpartum depression. Postpartum depression (PPD) has a significant negative impact on the child's emotional, mental as well as intellectual development if left untreated, which can later have long-term complications. Later in life, it also results in the mother developing obsessive-compulsive disorder and anxiety. Many psychol…
  • Dupilumab-Induced Lichen Planus: A Case with Oral and Cutaneous Eruptions. [Case Reports]
    Case Rep Dermatol. 2022 Sep-Dec; 14(3):356-361.Kern L, Kleinheinrich L, … Breier F
  • Lichen planus is a chronic, inflammatory, immune-mediated dermatosis affecting the patient's skin, scalp, mucous membranes, and nails. Drug-induced lichen planus is described after the administration of antimalarials, β-blockers, methyldopa, NSAIDs, penicillamines, and sodium aurothiomalate. The use of biologicals such as adalimumab, etanercept, and infliximab has also been linked with the appear…
  • [Triple combination of levodopa, carbidopa and entacapone by intrajejunal pump in advanced Parkinson's disease]. [Review]
    Ideggyogy Sz. 2022 Nov 30; 75(11-12):365-368.Györfi B, Baló B, … Jost WH
  • In advanced Parkinson's disease, oral medication can often no longer achieve sufficient therapeutic success. As one of the device aided therapies, the intrajejunal levo-dopa administration has been established as valuable treatment option. A modern form of the well-known intestinal levodopa pump offers the opportunity to continue the oral triple combination of levodopa, carbidopa and entacapone t…
  • Comparability of Foslevodopa/Foscarbidopa Pharmacokinetics in Healthy Asian and White Participants. [Journal Article]
    Clin Pharmacol Drug Dev. 2022 Nov 16 [Online ahead of print]Rosebraugh M, Neenan M, Facheris M
  • This phase 1 study assessed the safety, tolerability, and pharmacokinetics of a single 24-hour continuous subcutaneous dose of foslevodopa/foscarbidopa in healthy adult Japanese (N = 24), Han Chinese (N = 8), and White (N = 24) participants. Three doses of foslevodopa/foscarbidopa were evaluated in healthy participants for this study: 480/24, 960/48, and 1440/72 mg/day. Serial blood samples for m…
  • [COVID-19 as a trigger of autoimmune hepatitis. Case report]. [Case Reports]
    Ter Arkh. 2022 Feb 15; 94(2):259-264.Volchkova EA, Legkova KS, Topchy TB
  • Over the past two years, the entire medical community has taken up the fight against the new coronavirus infection. At the initial encounter with COVID-19, it seemed that this virus mainly affects the respiratory system. Still, with long-term observation, it turned out that the consequences of this disease can be much more severe and associated with lung damage and thromboembolic complications, a…
  • Why do 'OFF' periods still occur during continuous drug delivery in Parkinson's disease? [Review]
    Transl Neurodegener. 2022 10 13; 11(1):43.Rota S, Urso D, … Chaudhuri KR
  • Continuous drug delivery (CDD) is used in moderately advanced and late-stage Parkinson's disease (PD) to control motor and non-motor fluctuations ('OFF' periods). Transdermal rotigotine is indicated for early fluctuations, while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel are utilised in advanced PD. All three strategies are considered examples of continuous dopaminerg…
  • Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. [Review]
    Eur J Clin Pharmacol. 2022 Nov; 78(11):1763-1776.van de Vusse D, Mian P, … Versmissen J
  • CONCLUSIONS: We conclude that despite decades of prescribing methyldopa, labetalol, and nifedipine throughout pregnancy, descriptions of their PK during pregnancy are hampered by a large heterogeneity in the low number of available studies. Aiming for evidence-based and personalized dosing of antihypertensive medication in the future, further studies on the relationship of both PK and pharmacodynamics (including the optimal blood pressure targeting) during pregnancy and pregnancy-related pathology are urgently needed to prevent undertreatment, overtreatment, and side effects.
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