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30,601 results
  • Optimization of CFTR gating through the evolution of its extracellular loops. [Journal Article]
    J Gen Physiol. 2023 Apr 03; 155(4)Simon MA, Csanády L
  • CFTR chloride channel mutations cause the lethal and incurable disease cystic fibrosis (CF). CFTR is activated by phosphorylation, and phosphorylated channels exhibit "bursting" behavior-"bursts" of openings separated by short "flickery" closures and flanked by long "interburst" closures-driven by ATP binding/hydrolysis at two nucleotide-binding domains. The human channel (hCFTR) and the distant …
  • Design of transition metal complexes containing a P-E radical motif. [Journal Article]
    Dalton Trans. 2023 Jan 31 [Online ahead of print]Zhu H, Qu ZW, … Streubel R
  • Recently, we have synthesized phosphane W(CO)5 complexes containing a P-O-TEMP ligand motif as bench-stable precursors of thermally accessible phosphanoxyl complex radicals possessing a ligand with a P-O˙ group. In this work, extensive dispersion-corrected DFT calculations are used to explore both W(CO)5 and Fe(CO)4 phosphane complexes containing the P-E-TEMP ligands (E = O, S, NMe, and PMe) in o…
  • Type 2 Diabetes and HDL dysfunction: a key contributor to Glycemic Control. [Journal Article]
    Curr Med Chem. 2023 Feb 01 [Online ahead of print]Rotllan N, Julve J, Escolà-Gil JC
  • High-density lipoproteins (HDL) have been shown to exert multiple cardioprotective and antidiabetic functions, such as their ability to promote cellular cholesterol efflux and their antioxidant, anti-inflammatory, and antiapoptotic properties. Type 2 diabetes (T2D) is usually associated with low high-density lipoprotein cholesterol (HDL-C) levels as well as with significant alterations in the HDL…
  • Exploring the Folding Mechanism of Dimeric Superoxide Dismutase. [Journal Article]
    J Phys Chem B. 2023 Jan 30 [Online ahead of print]Mouro PR, Sanches MN, … Chahine J
  • The Cu/Zn Human Superoxide Dismutase (SOD1) is a dimeric metalloenzyme whose genetic mutations are directly related to amyotrophic lateral sclerosis (ALS), so understanding its folding mechanism is of fundamental importance. Currently, the SOD1 dimer formation is studied via molecular dynamics simulations using a simplified structure-based model and an all-atom model. Results from the simplified …
  • Stepwise assembly of the active site of [NiFe]-hydrogenase. [Journal Article]
    Nat Chem Biol. 2023 Jan 26 [Online ahead of print]Caserta G, Hartmann S, … Lenz O
  • [NiFe]-hydrogenases are biotechnologically relevant enzymes catalyzing the reversible splitting of H2 into 2e- and 2H+ under ambient conditions. Catalysis takes place at the heterobimetallic NiFe(CN)2(CO) center, whose multistep biosynthesis involves careful handling of two transition metals as well as potentially harmful CO and CN- molecules. Here, we investigated the sequential assembly of the …
  • Impact of Rabeprazole on APO-Dabigatran Exposure in Healthy Volunteers. [Journal Article]
    CJC Open. 2023 Jan; 5(1):1-7.Chan N, Wheeler M, … Eikelboom J
  • CONCLUSIONS: When APO-dabigatran is administered with rabeprazole, the exposure to dabigatran is reduced by about 30%, which is similar to the level observed with Pradaxa when it was co-administered with a proton pump inhibitor. However, the finding that one-third of participants had a > 50% reduction in exposure is concerning, and it highlights the need for caution in patients who have, or are at risk of, reduced gastric acidity.
  • Ixodes ricinus ticks have a functional association with Midichloria mitochondrii. [Journal Article]
    Front Cell Infect Microbiol. 2022; 12:1081666.Guizzo MG, Hatalová T, … Perner J
  • In addition to being vectors of pathogenic bacteria, ticks also harbor intracellular bacteria that associate with ticks over generations, aka symbionts. The biological significance of such bacterial symbiosis has been described in several tick species but its function in Ixodes ricinus is not understood. We have previously shown that I. ricinus ticks are primarily inhabited by a single species of…
  • Design of a gold clustering site in an engineered apo-ferritin cage. [Journal Article]
    Commun Chem. 2022 Mar 21; 5(1):39.Lu C, Maity B, … Lu D
  • Water-soluble and biocompatible protein-protected gold nanoclusters (Au NCs) hold great promise for numerous applications. However, design and precise regulation of their structure at an atomic level remain challenging. Herein, we have engineered and constructed a gold clustering site at the 4-fold symmetric axis channel of the apo-ferritin cage. Using a series of X-ray crystal structures, we eva…
  • Lutein nanodisks protect human retinal pigment epithelial cells from UV light-induced damage. [Journal Article]
    Front Nanotechnol. 2022; 4Moschetti A, Fox CA, … Ryan RO
  • The hydrophobic carotenoid, lutein, was conferred with aqueous solubility upon formulation into reconstituted discoidal high density lipoprotein particles, termed lutein nanodisks (ND). When formulated with phosphatidylcholine (PC), apolipoprotein (apo) A-I and lutein (formulation ratio = 5 mg PC/2 mg apoA-I/1 mg lutein), lutein solubilization efficiency in phosphate buffered saline (PBS) was ~90…
  • Identification of Plasma Proteomic Biomarkers in Patients with Mild Cognitive Impairment. [Journal Article]
    Indian J Clin Biochem. 2023 Jan; 38(1):33-41.Singh V, Mishra VN, Thakur MK
  • Plasma proteomic profiling may provide novel biomarkers for the identification of mild cognitive impairment (MCI). The early diagnosis of MCI still remains a challenging task due to its diverse origin. Currently, molecular approaches have been used to identify MCI diversified origin as its onset is governed by a variety of molecular changes. Therefore, we aimed to find out molecular alteration in…
  • Protoporphyrin IX Binds to Iron(II)-Loaded and to Zinc-Loaded Human Frataxin. [Journal Article]
    Life (Basel). 2023 Jan 12; 13(1)Bernardo-Seisdedos G, Schedlbauer A, … Millet O
  • (1) Background: Human frataxin is an iron binding protein that participates in the biogenesis of iron sulfur clusters and enhances ferrochelatase activity. While frataxin association to other proteins has been extensively characterized up to the structural level, much less is known about the putative capacity of frataxin to interact with functionally related metabolites. In turn, current knowledg…
  • Biomarkers for Premature Coronary Artery Disease (PCAD): A Case Control Study. [Journal Article]
    Diagnostics (Basel). 2023 Jan 04; 13(2)Shukor MFA, Musthafa QA, … Ismail NAS
  • Coronary artery disease (CAD) is often associated with the older generation. However, in recent years, there is an increasing trend in the prevalence of CAD among the younger population; this is known as premature CAD. Although biomarkers for CAD have been established, there are limited studies focusing on premature CAD especially among the Malay male population. Thus, the aim of this research wa…
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