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Unbound Medicine.
(Apo Primidone)
1,911 results
  • PaxlovidTM Information From FDA and Guidance for AES Members. [Journal Article]
    Epilepsy Curr. 2022 Jun; 22(3):201-204.Cokley JA, Gidal BE, … Reviewed and approved by the AES Treatments Committee and Council on Clinical Activities
  • This American Epilepsy Society (AES) official statement provides information and preliminary guidance to Society members related to the U.S. Food & Drug Administration (FDA) December 22, 2021 Emergency Use Authorization for Paxlovid™ for the oral treatment of mild to moderate COVID-19 in adults and children (≥12 years and weighing ≥40 kg). Paxlovid is likely to be widely prescribed, and important…
  • StatPearls: Barbiturates [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)SkibiskiJeanieJMissouri State UniversityAbdijadidSaraSUCLABOOK
  • Barbiturates are a group of sedative-hypnotic medications used for the treatment of seizure disorder, neonatal withdrawal, insomnia, preoperative anxiety, induction of coma for increased intracranial pressure. They are also useful for inducing anesthesia. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitorin…
  • Isolated slow orthostatic tremor of the trunk. [Letter]
    Neurol Res Pract. 2022 Oct 17; 4(1):51.Aziz NA, Grobe-Einsler M, Kaut O
  • Slow orthostatic tremor is an extremely rare movement disorder with relatively low-frequency tremor (< 13 Hz) in the legs and trunk, which is evoked by standing. There is still much controversy regarding its precise etiology. Here we present a 57 year-old female patient with a slow orthostatic tremor variant who experienced progressive gait disturbances since six years due to isolated trunk tremo…
  • StatPearls: Primidone [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)LenkapothulaNareshNNova college of pharmacyCascellaMarcoMIstituto Nazionale Tumori - IRCCS - Fondazione Pascale, Via Mariano Semmola 80100, Napoli. ItalyBOOK
  • Primidone is an aromatic anticonvulsant used to treat complex, partial, and generalized seizures. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of primidone in the clinical setting related to the essential points needed by members of an interprofessional team managing the care of patients with epilepsy.
  • Antiseizure Drugs and Movement Disorders. [Review]
    CNS Drugs. 2022 08; 36(8):859-876.Sáenz-Farret M, Tijssen MAJ, … Fasano A
  • The relationship between antiseizure drugs and movement disorders is complex and not adequately reviewed so far. Antiseizure drugs as a treatment for tremor and other entities such as myoclonus and restless leg syndrome is the most common scenario, although the scientific evidence supporting their use is variable. However, antiseizure drugs also represent a potential cause of iatrogenic movement …
  • StatPearls: Barbiturate Toxicity [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)SuddockJolee T.JTUniversity of New MexicoCainMatthew D.MDUn of New Mexico HospitalBOOK
  • Barbiturates are a class of sedative-hypnotic drugs. They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental). Some states administer barbiturates for physician-assisted suicide/euthanasia and use them for capital punishment by lethal injection. Their use in clinical practice has largely been replaced by benzodiazepines such as alprazolam, …
  • Enhancing GABA inhibition is the next generation of medications for essential tremor. [Journal Article]
    Int Rev Neurobiol. 2022; 163:317-334.Ondo W
  • γ-Aminobutyric acid (GABA) is the most prevalent inhibitory CNS neurotransmitter. Activating GABA-A receptors hyperpolarizes cells via Cl- influx, which inhibits action potentials. Although the exact pathophysiologies of tremor are incompletely understood, proposed neuroanatomy extensively implicates GABA pathways. Pathological studies and imaging studies also show GABA abnormalities in patients …
  • Antiepileptic Drugs and Their Dual Mechanism of Action on Carbonic Anhydrase. [Journal Article]
    J Clin Med. 2022 May 06; 11(9)Magheru C, Magheru S, … Farcas DM
  • (1) Background: The benefit of using inhibitors of carbonic anhydrase (CA), such as acetazolamide, in the treatment of epilepsy has previously been described. (2) Methods: In this paper, the effect on CA of the most well-known antiepileptic drugs was studied in vitro and in vivo. The effects, after chronic treatment, of carbamazepine, phenytoin, valproate, primidone, clonazepam, and ethosuximide …
  • Acute elevation of liver function test values following concomitant administration of dabigatran and primidone. [Case Reports]
    Am J Health Syst Pharm. 2022 07 22; 79(15):1250-1254.Caviness LA, Wassell KM, Howard-Thompson A
  • CONCLUSIONS: Studies have indicated a potential for reduced dabigatran efficacy with concurrent use of primidone due to P-glycoprotein induction, thereby potentiating the risk for thrombosis. To date, reports of this interaction resulting in hepatic injury are lacking. The present case suggests that this interaction may be clinically significant with regard to selection of antithrombotic medication therapy in patients on primidone therapy.
  • Primidone Intolerance in Essential tremor: Is it More than Just Age? [Review]
    Tremor Other Hyperkinet Mov (N Y). 2021; 11:57.Lenka A, Louis ED
  • CONCLUSIONS: We speculate that there are several possible explanations for primidone intolerance in ET. These possibilities should be tested in future studies, and we propose the roadmap for designing these studies. It is of value to obtain detailed insight into these complex issues because primidone remains one of the few frontline anti-tremor medications in ET. Answers to issues we have raised in this article could facilitate more customized formulation of primidone in ET patients.
  • Drugs and Lactation Database (LactMed): Primidone [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Ample evidence exists that primidone taken during nursing can affect the breastfed infant. Infant serum levels of primidone and its metabolites are often near or in the therapeutic range and symptoms of sedation and poor nursing have been reported. On the other hand, infants exposed in utero sometimes have withdrawal symptoms that are either alleviated by breastfeeding or worsened when breastfeed…
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