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(Apo Primidone)
1,793 results
  • StatPearls [BOOK]
  • BOOKStatPearls Publishing: Treasure Island (FL)
  • Suddock Jolee T. JT University of New Mexico Cain Matthew D. MD University of New Mexico Hospital/Office of the Medical Investigator
  • Barbiturates are a class of sedative-hypnotic drugs. They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental). Some states administer barbitur...
  • High-dose thiamine and essential tremor. [Journal Article]
  • BCBMJ Case Rep 2018 Mar 30; 2018
  • Costantini A
  • Essential tremor is a common neurological disease. The medical treatment of this affection currently involves the use of propranolol, primidone and other drugs. These drugs, however, are often not ef...
  • [Use of antiepileptic drugs during breastfeeding : What do we tell the mother?] [Journal Article]
  • NNervenarzt 2018 Feb 27
  • Crettenand M, Rossetti AO, … Winterfeld U
  • CONCLUSIONS: Phenobarbital, primidone, carbamazepine, valproate and levetiracetam are probably compatible with breastfeeding. Treatment with phenytoin, ethosuximide, clonazepam, oxcarbazepine, vigabatrin, topiramate, gabapentin, pregabalin, lamotrigine and zonisamide can be authorized during breastfeeding, provided breastfed infants are carefully monitored for side effects. Since data on the use of mesuximide, clobazam, rufinamide, felbamate, lacosamide, sultiame, perampanel and retigabine are insufficient to adequately assess the risk for breastfed infants, use in breastfeeding women is in principle not recommended and should be carefully evaluated on a case by case basis. In practice, a risk-benefit analysis should be performed for each mother under antiepileptic treatment wishing to breastfeed her child, so that individual risk factors can adequately be taken into account when counseling the patient.
  • A descriptive systematic review of salivary therapeutic drug monitoring in neonates and infants. [Journal Article]
  • BJBr J Clin Pharmacol 2018; 84(6):1089-1108
  • Hutchinson L, Sinclair M, … Callan B
  • CONCLUSIONS: There is significant potential for infantile saliva testing and in particular for neutral and weakly acidic compounds. Of the properties investigated, pKa was the most influential with both logP and protein binding having little effect on this correlation. To conclude, any compound with a pKa within physiological range (pH 6-8) should be considered with extra care, with the extraction and analysis method examined and optimized on a case-by-case basis.
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