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Unbound Medicine.
(Apo Propranolol)
27 results
  • Sympathetic nervous system mediates surgical trauma stress-induced splenocyte apoptosis in rats. [Journal Article]
    Eur J Pharmacol. 2007 Jun 22; 565(1-3):76-82.Wang J, Sun J, … Wu GC
  • Surgical trauma stress has been reported to induce immunosuppression. The mechanisms involved are still unclear. The present study was designed to assess the role of the sympathetic nervous system in regulating splenocyte apoptosis induced by surgical trauma stress. Our results showed that the rats that underwent surgical trauma stress exhibited a significant reduction in splenic cellularity, the…
  • Domain swapping in G-protein coupled receptor dimers. [Journal Article]
    Protein Eng. 1998 Dec; 11(12):1181-93.Gouldson PR, Snell CR, … Reynolds CA
  • Computer simulations were performed on models of the beta2-adrenergic receptor dimer, including 5,6-domain swapped dimers which have been proposed as the active, high affinity form (here the dimer interface lies between helices 5 and 6). The calculations suggest that the domain swapped dimer is a high energy structure in both the apo dimer and in the presence of propranolol. In the presence of ag…
  • Mildly oxidized LDL induces platelet aggregation through activation of phospholipase A2. [Journal Article]
    Arterioscler Thromb Vasc Biol. 1995 Aug; 15(8):1131-8.Weidtmann A, Scheithe R, … Siess W
  • Native LDL and LDL oxidized under various conditions were compared in terms of their ability to activate platelets. Native LDL did not induce platelet shape change or aggregation, even at high concentrations (2 mg protein/mL). LDL was mildly oxidized with either CuSO4 (mox-LDL) or 3-(N-morpholino)sydnonimine (SIN-1-LDL). Analysis of mox-LDL and SIN-1-LDL showed a small increase of dienes (E234nm …
  • Thyroid hormone (fT4) reduces lipoprotein(a) plasma levels. [Journal Article]
    Atherosclerosis. 1995 May; 115(1):65-71.Hoppichler F, Sandholzer C, … Kraft HG
  • To study the influence of thyroid hormone on Lp(a) plasma concentration we measured Lp(a), total cholesterol, LDL-C, HDL-C, triglycerides and fT4 levels and determined apo(a) phenotypes in 26 patients with hyperthyroidism in a follow-up study before and after thyreostatic treatment. The pretreatment values of total cholesterol (TC), LDL-C, and Lp(a) were significantly reduced as compared with tho…
  • Effects of serotonergic agents on apomorphine-induced locomotor activity. [Journal Article]
    Psychopharmacology (Berl). 1993; 110(1-2):97-102.Young KA, Zavodny R, Hicks PB
  • The interactions of serotonin 5-HT1A, 5-HT1C/2 and 5-HT3 receptor subtypes with apomorphine-induced locomotor activity (AILA) were investigated in Sprague-Dawley rats. The 5-HT3 antagonists ondansetron and ICS 205-930 had no significant effects on AILA. The 5-HT1A agonist 8-hydroxy-2-(di-N-propylamino) tetralin (8-OH-DPAT) produced an increase in locomotor activity that was independent of DA neur…
  • ICI 147,798: a novel diuretic agent with beta adrenoceptor blocking activity. [Journal Article]
    J Pharmacol Exp Ther. 1987 Sep; 242(3):818-26.Kau ST, Howe BB, … Goldberg ME
  • ICI 147,798 is a novel compound which has both diuretic and beta adrenoceptor blocking properties in a single molecule. The natriuretic activity at 30 mg/kg p.o. was about 65% of the hydrochlorothiazide value at 10 mg/kg p.o. in saline-loaded rats; the corresponding kaliuretic activity was 42%. The natriuretic and the kaliuretic activity of ICI 147,798 in dogs were similar to that of hydrochlorot…
  • Serum lipids in hyper- and hypothyroidism before and after treatment. [Journal Article]
    Clin Chim Acta. 1987 Jan 30; 162(2):155-63.Friis T, Pedersen LR
  • Total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides (TG) and apoprotein A (Apo A) were determined in serum from 21 hyperthyroid patients and 11 hypothyroid patients before and after treatment to euthyroid state. The above-mentioned components were also determined in a reference population. In the hyperthyroid group the c…
  • Effect of prazosin and propranolol on lipoproteins of hypertensive patients. [Randomized Controlled Trial]
    Biomed Biochim Acta. 1987; 46(1):111-8.Hurt E, Velasco M, … Camejo G
  • A comparative study between prazosin and propranolol with twenty male patients with mild to moderate essential hypertension was used to study the effects of these antihypertensive agents on plasma lipoproteins, and more specifically high density lipoproteins-2 and Apo A-I. After 4 weeks on placebo, the patients were randomly assigned to prazosin therapy (Group A) and other ten patients to propran…
  • Phosphorus-nitrogen compounds. 24. Phosphoramide mustard carrier derivatives. [Journal Article]
    J Med Chem. 1984 Mar; 27(3):397-401.Cates LA, Li VS, … van der Helm D
  • Diethylstilbestrol, psoralen, and propranolol were used as potential carrier molecules for selective concentrations of a nitrogen mustard moiety in breast, skin, and lung tissues, respectively. The propranolol derivative gave two racemic mixtures, which were tested to ascertain any differences in anticancer activity. The insertion of a P = O group between the carrier and oncolytic portions offset…
  • Effects of apomorphine, TL-99 and 3-PPP on yawning in rats. [Journal Article]
    Neuropharmacology. 1984 Jan; 23(1):19-22.Mogilnicka E, Boissard CG, Delini-Stula A
  • Dopaminergic agonists, apomorphine (APO) (0.025-0.25 mg/kg, s.c.), TL-99 (0.5-3 mg/kg, s.c.) and 3-PPP (0.15-10 mg/kg, s.c.) elicited yawning in rats and the dose-response curves of all 3 compounds showed a bell-shaped form. Haloperidol (0.02 mg/kg, s.c.) reduced the yawning induced by DA-agonists to about 50%. The potencies of the DA-agonists in inducing yawning were APO greater than TL-99 great…
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