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Unbound Medicine.
(Apo Quinidine)
9,268 results
  • Cardiocerebral channelopathy caused by KCND3 mutation in a child: A case report. [Case Reports]
    Front Pediatr. 2022; 10:1019122.Zhang Y, Jiang H, Li XM
  • Early repolarization syndrome is rare in children. Mutation of genes encoding ion channels could display mixed electrophysiological phenotype of Kv4.3 including both cardiac phenotype (early repolarization syndrome, atrial fibrillation) and cerebral phenotype (epilepsy, intellectual disability). This situation is rare and was named as cardiocerebral channelopathy. Here, we report a case of an 11-…
  • Protein 14-3-3 Influences the Response of the Cardiac Sodium Channel Nav1.5 to Anti-Arrhythmic Drugs. [Journal Article]
    J Pharmacol Exp Ther. 2022 Dec 02 [Online ahead of print]Zheng Y, Deschenes I
  • The cardiac sodium channel Nav1.5 is a key contributor to the cardiac action potential and dysregulations in Nav1.5 can lead to cardiac arrhythmias. Nav1.5 is a target of numerous antiarrhythmic drugs (AADs). Previous studies identified the protein 14-3-3 as a regulator of Nav1.5 biophysical coupling. Inhibition of 14-3-3 can remove the Nav1.5 functional coupling and has been shown to inhibit the…
  • New use for an old drug: quinidine in KCNT1-related epilepsy therapy. [Review]
    Neurol Sci. 2022 Nov 28 [Online ahead of print]Liu R, Sun L, … Wu J
  • KCNT1 has been known to encode a subunit of the tetrameric sodium activated potassium channel (KNa1.1). Pathogenic variants of KCNT1, especially gain-of-function (GOF) variants, are associated with multiple epileptic disorders which are often refractory to conventional anti-seizure medications and summarized as KCNT1-related epilepsy. Although the detailed pathogenic mechanisms of KCNT1-related e…
  • StatPearls: Cinchonism [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)BykowskiAdamAMclaren Health SystemLoganTimothy D.TDMichigan State University College of Osteopathic MedicineBOOK
  • Cinchonism is a collection of symptoms stemming from the ingestion of quinoline derivatives and their subsequent neural, retinal, and auditory toxicity. Ingestion of quinoline derivatives can produce a multitude of detrimental effects. Cinchonism is a subset of these effects originally believed to be primarily neurally mediated. This definition does not include the pro-arrhythmic properties of th…
  • Approaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy. [Journal Article]
    Expert Opin Drug Discov. 2022 12; 17(12):1313-1328.Miziak B, Czuczwar SJ
  • There are approximately 70 million people with epilepsy and about 30% of patients are not satisfactorily treated. A link between gene mutations and epilepsy is well documented. A number of pathological variants of KCNT1 gene (encoding the weakly voltage-dependent sodium-activated potassium channel - KNa 1.1) mutations has been found. For instance, epilepsy of infancy with migrating focal seizures…
  • Dextromethorphan: From Cough Suppressant to Antidepressant. [Journal Article]
    J Psychosoc Nurs Ment Health Serv. 2022 Nov; 60(11):9-11.Kverno K
  • Dextromethorphan (DXM) has been re-purposed several times over the past 7 decades: first as a cough suppressant, then as a compounded formulation with quinidine for treatment of pseudobulbar affect, and most recently as a compounded formulation with bupro-pion for treatment of major depressive disorder. The current article describes the history and purported mechanisms of action of DXM for each u…
  • StatPearls: Plant Alkaloids Toxicity [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)VezikovLisa V.LVLake Erie College of Osteopathic Medicine, Greensburg, PASimpsonMichaelMHarvard Medical SchoolBOOK
  • Plant chemistry and toxicology are complex with a rich history. Much about plant chemistry remains unknown, and our understanding relies on animal research combined with documented human experiences. The dynamic science of pharmacognosy, which highlights the therapeutic value of plants, has elucidated several major classes of organic molecules found in plants, of which alkaloids represent one. Ot…
  • Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with KCNT1 Genetic Variants. [Journal Article]
    Pharmaceutics. 2022 Oct 19; 14(10)Ferretti A, Simeoli R, … Goffredo BM
  • Quinidine (QND) is an old antimalarial drug that was used in the early 20th century as an antiarrhythmic agent. Currently, QND is receiving attention for its use in epilepsy of infancy with migrating focal seizures (EIMFS) due to potassium sodium-activated channel subfamily T member 1 (KCNT1) genetic variants. Here, we report the application of Therapeutic Drug Monitoring (TDM) in pediatric patie…
  • Susac Syndrome With Livedo Reticularis: Pathogenesis and Literature Review. [Case Reports]
    Cureus. 2022 Jul; 14(7):e27352.Srichawla BS
  • Susac syndrome (SuS) is a rare autoimmune endotheliopathy that affects the retina, cochlea, and central nervous system (CNS). Even fewer cases of SuS have been reported with dermatological findings, including livedo reticularis and racemosa. The case of SuS reported here presents with encephalopathy, visual disturbances, hearing loss, and a diffuse rash on the abdomen and flank. Magnetic resonanc…
  • GeneReviews®: Brugada Syndrome [BOOK]
    GeneReviews®. University of Washington, Seattle: Seattle (WA)Adam MP, Mirzaa GM, … Amemiya ABrugada R, Campuzano O, … Hong KBOOK
  • Brugada syndrome is characterized by cardiac conduction abnormalities (ST-segment abnormalities in leads V1-V3 on EKG and a high risk for ventricular arrhythmias) that can result in sudden death. Brugada syndrome presents primarily during adulthood although age at diagnosis may range from infancy to late adulthood. The mean age of sudden death is approximately 40 years. Clinical presentations may…
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