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(Apo Quinidine)
8,859 results
  • Lack of response to quinidine in KCNT1-related neonatal epilepsy. [Journal Article]
  • EEpilepsia 2018 Sep 04
  • Numis AL, Nair U, … Cilio MR
  • CONCLUSIONS: Patients had no reported benefit to quinidine therapy despite age at treatment initiation. Pharmacogenetic results in oocytes were consistent with clinical treatment failure in 2 patients, suggesting that single-dose pharmacologic assessment may be helpful in predicting which patients are exceedingly unlikely to achieve benefit with quinidine. In the 2 patients who had a lack of therapeutic benefit despite sensitivity to high concentrations of quinidine with in vitro oocyte assay, it is likely that the achievable exposure levels in the brain were too low to cause significant in vivo channel blockade.
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