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(Apo Quinidine)
8,821 results
  • Severe Plasmodium falciparum Malaria Treated With Investigational Artesunate in the United States. [Journal Article]
  • JPJ Pharm Pract 2018 Jan 01; :897190018782367
  • Shah PJ, Koshy J, … Attia E
  • CONCLUSIONS: A 40-year-old Nigerian male was admitted to the medical intensive care unit for the treatment of severe malaria. The patient presented with the classic malaria paroxysm and altered mental status and was in acute renal failure. A blood parasite, thick and thin smear was performed revealing positive ring forms on smear which are characteristic of Plasmodium falciparum, with an estimated parasitemia of 2%. Per the Centers for Disease Control and Prevention (CDC) guidelines, the recommended treatment for severe malaria is with IV quinidine, the only Food and Drug Administration (FDA)-approved medication available for the treatment of severe malaria in the United States. However, quinidine was not immediately available, including from surrounding hospitals. As a result, the infectious diseases physician and pharmacist decided to contact the CDC to initiate the process for obtaining IV artesunate, an investigational drug only available via a FDA-approved Investigational New Drug (IND) protocol. Artesunate was flown into Houston later that night, and this drug was administered successfully to the patient. Patient responded to treatment and was discharged from the hospital on day 4.A patient with severe falciparum malaria was successfully treated with investigational artesunate procured from the CDC.
  • DKA-induced Brugada phenocopy mimicking STEMI. [Journal Article]
  • HAHeart Asia 2018; 10(2):e011027
  • Abrahim C, Maharaj S
  • A 47-year-old Caucasian woman with type 1 diabetes presented with epigastric pain and vomiting. She had not been adherent with her diet and insulin therapy for the past 3 weeks. She never had a perso...
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