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Unbound Medicine.
(Apo Sulfatrim)
13 results
  • Drugs and Lactation Database (LactMed): Trimethoprim [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because of the low levels of trimethoprim in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
  • Effects of co-operative ligand binding on protein amide NH hydrogen exchange. [Journal Article]
    J Mol Biol. 2006 Mar 03; 356(4):886-903.Polshakov VI, Birdsall B, Feeney J
  • Amide protection factors have been determined from NMR measurements of hydrogen/deuterium amide NH exchange rates measured on assigned signals from Lactobacillus casei apo-DHFR and its binary and ternary complexes with trimethoprim (TMP), folinic acid and coenzymes (NADPH/NADP(+)). The substantial sizes of the residue-specific DeltaH and TDeltaS values for the opening/closing events in NH exchang…
  • Pharmacokinetics and bioavailability of trimethoprim-sulfamethoxazole in alpacas. [Journal Article]
    J Vet Pharmacol Ther. 2002 Oct; 25(5):321-7.Chakwenya J, Lakritz J, … Holle J
  • The pharmacokinetics and bioavailability of trimethoprim-sulfamethoxazole (TMP-SMX) were studied in six healthy male-castrate alpacas (Lama pacos) after intravenous (i.v.) or oral (p.o.) drug administration of 15 mg/kg TMP-SMX using a crossover design with a 2-week washout period. After 90 days one group (n = 3) was given a p.o. dose of 30 mg/kg TMP-SMX and the other group (n = 3) was given a p.o…
    Med J Armed Forces India. 1999 Apr; 55(2):115-118.Misra RN, Debata NK, … Ohri VC
  • A total of 338 urinary isolates were studied at AFMC, Pune during 1998 for species identification and antibiotic resistance. Out of 145 community isolates E coli were 67% followed by Staph aureus (11%). The hospital isolates of E coli and Proteus spp showed higher resistance to ampicillin (81% and 89% respectively) than to cefotaxime (23% and 22% respectively). K pneumoniae showed relatively high…
  • Structure and function of the dihydropteroate synthase from Staphylococcus aureus. [Journal Article]
    J Mol Biol. 1997 Apr 25; 268(1):21-30.Hampele IC, D'Arcy A, … Then RL
  • The gene encoding the dihydropteroate synthase of staphylococcus aureus has been cloned, sequenced and expressed in Escherichia coli. The protein has been purified for biochemical characterization and X-ray crystallographic studies. The enzyme is a dimer in solution, has a steady state kinetic mechanism that suggests random binding of the two substrates and half-site reactivity. The crystal struc…
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