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2,138 results
  • Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma. [Journal Article]
    Carcinogenesis. 2022 Nov 10 [Online ahead of print]Kadariya Y, Sementino E, … Testa JR
  • Malignant mesothelioma (MM) is an incurable cancer of the serosal lining that is often caused by exposure to asbestos. Therefore, novel agents for the prevention and treatment of this disease are urgently needed. Asbestos induces the release of pro-inflammatory cytokines such as IL-1β and IL-6, which play a role in MM development. IL-6 is a component of the JAK-STAT3 pathway that contributes to i…
  • StatPearls: Sulindac [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)MunjalAkulAMedical College of GeorgiaWadhwaRoopmaRSouth Carolina Department of Mental HealthBOOK
  • Sulindac is a medication used in a host of conditions. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of therapy in the clinical setting related to the essential points needed by members of an interprofessional team.
  • Mechanical strength of antibiotic-loaded PMMA spacers in two-stage revision surgery. [Journal Article]
    BMC Musculoskelet Disord. 2022 Oct 29; 23(1):945.Lunz A, Knappe K, … Jaeger S
  • CONCLUSIONS: This study suggests that mechanical strength of antibiotic-loaded PMMA bone cement critically decreases even over the short time period of six weeks, which is the recommended interim period in the setting of two-stage revision. This potentially results in an increased risk for PMMA spacer fracture at the end of the interim period and especially in patients with prolonged interim periods. Finally, we conclude that intraoperative addition of 4 g of vancomycin powder per 40 g of gentamicin-premixed Palacos R + G (Group D) is mechanically the preparation of choice if a dual antibiotic-loaded bone cement spacer with high antibiotic concentrations and good stability is warranted. In any case the written and signed informed consent including the off-label use of custom-made antibiotic-loaded PMMA bone cement spacers must be obtained before surgery.
  • Colorectal Carcinoma, Cyclooxygenases, and COX Inhibitors. [Review]
    Cureus. 2022 Aug; 14(8):e28579.Ganduri V, Rajasekaran K, … Manjunatha N
  • Colorectal carcinoma (CRC) is the most common of gastrointestinal cancers, the majority presenting with sporadic occurrence compared to the less frequently inherited syndromes. The increasing incidence, decreasing gender and age disparities, and the prevalent risk factors are concerning. The malignancy arising from benign precursor polyps transforms slowly over time. The adenoma variant polyps re…
  • A novel sulindac derivative protects against oxidative damage by a cyclooxygenase-independent mechanism. [Journal Article]
    J Pharmacol Exp Ther. 2022 Jun 09 [Online ahead of print]Allani SK, Rayala R, … Weissbach H
  • Oxidative damage is believed to play a major role in the etiology of many age-related diseases and the normal aging process. We previously reported that sulindac, a cyclooxygenase (COX) inhibitor and FDA approved anti-inflammatory drug, has chemoprotective activity in cells and intact organs by initiating a pharmacological preconditioning response, similar to ischemic preconditioning (IPC). The m…
  • Long-term chemoprevention in patients with adenomatous polyposis coli: an observational study. [Journal Article]
    Fam Cancer. 2022 10; 21(4):463-472.Neuhann TM, Haub K, … Holinski-Feder E
  • Prospective short-term studies on effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) point towards a decrease in the number and size of polyps. Effectiveness and safety in the prevention of progression in familial polyposis with NSAIDs in long-term use, which is the prerequisite for therapeutic evaluation in prospective studies, is unknown. The total absolute observation period of 54…
  • Photoisomerization of Sulindac and Ozagrel Hydrochloride by Vitamin B2 Catalyst Under Visible Light Irradiation. [Journal Article]
    Pharm Res. 2022 Mar; 39(3):577-586.Suga M, Makino K, … Takahashi H
  • CONCLUSIONS: The catalytic activity of vitamin B2 or FAD was demonstrated in the photoisomerization reaction of sulindac and ozagrel hydrochloride. Considering that the rate of photoisomerization in D2O is very slow, the possibility of the occurrence of photoisomerization during clinical use is low. However, this study suggests that the interfusion of vitamin B2 or FAD under excessive light exposure should be avoided as a caution during intravenous administration of sulindac or ozagrel hydrochloride.
  • Kolaviron protects rats from cognitive decline induced by Lipopolysaccharide in Wistar rat. [Journal Article]
    Niger J Physiol Sci. 2021 Jun 30; 36(1):67-76.Onasanwo SA, Adebimpe-John OE, … Olajide OO
  • Kolaviron is a mixture of bi-flavonoids from seed Garcinia kola seed, and has been previously shown to exhibit Nrf2 antioxidant-mediated inhibition of neuroinflammation in LPS-activated BV2 microglia. In this study, we investigated neuroprotective effects of kolaviron in LPS-induced memory impairment in rats. Wistar rats (225-250) g was used for this study. Memory impairment was induced with the …
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