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Unbound Medicine.
(Apo Tetra)
33 results
  • GAPDH delivers heme to soluble guanylyl cyclase. [Journal Article]
    J Biol Chem. 2020 06 12; 295(24):8145-8154.Dai Y, Sweeny EA, … Stuehr DJ
  • Soluble guanylyl cyclase (sGC) is a key component of NO-cGMP signaling in mammals. Although heme must bind in the sGC β1 subunit (sGCβ) for sGC to function, how heme is delivered to sGCβ remains unknown. Given that GAPDH displays properties of a heme chaperone for inducible NO synthase, here we investigated whether heme delivery to apo-sGCβ involves GAPDH. We utilized an sGCβ reporter construct, …
  • d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils. [Journal Article]
    Chemistry. 2017 Jun 16; 23(34):8232-8243.Ruckthong L, Peacock AFA, … Pecoraro VL
  • Although metal ion binding to naturally occurring l-amino acid proteins is well documented, understanding the impact of the opposite chirality (d-)amino acids on the structure and stereochemistry of metals is in its infancy. We examine the effect of a d-configuration cysteine within a designed l-amino acid three-stranded coiled coil in order to enforce a precise coordination number on a metal cen…
  • Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. [Journal Article]
    Nat Chem Biol. 2016 10; 12(10):795-801.Pollock JA, Wardell SE, … Norris JD
  • Clinical resistance to the second-generation antiandrogen enzalutamide in castration-resistant prostate cancer (CRPC), despite persistent androgen receptor (AR) activity in tumors, highlights an unmet medical need for next-generation antagonists. We have identified and characterized tetra-aryl cyclobutanes (CBs) as a new class of competitive AR antagonists that exhibit a unique mechanism of actio…
  • Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa. [Journal Article]
    FEBS J. 2016 Mar; 283(6):1088-106.Yang X, Matsui T, … Morita H
  • In polyketide biosynthesis, ring formation is one of the key diversification steps. Olivetolic acid cyclase (OAC) from Cannabis sativa, involved in cannabinoid biosynthesis, is the only known plant polyketide cyclase. In addition, it is the only functionally characterized plant α+β barrel (DABB) protein that catalyzes the C2-C7 aldol cyclization of the linear pentyl tetra-β-ketide CoA as the subs…
  • Calorimetric and spectroscopic investigations of the binding of metallated porphyrins to G-quadruplex DNA. [Journal Article]
    Biochim Biophys Acta. 2016 May; 1860(5):902-909.DuPont JI, Henderson KL, … Lewis EA
  • CONCLUSIONS: In the case of apo-TMPyP4, Ni(II)-TMPyP4, and Cu(II)-TMPyP4, the thermodynamic signatures for the two binding modes are consistent with an "end stacking" mechanism for the higher affinity binding mode and an "intercalation" mechanism for the lower affinity binding mode. In the case of Co(III)-TMPyP4 and Zn(II)-TMPyP4, both the lower affinity for the "end-stacking" mode and the loss of the intercalative mode for forming the 2:1 complexes with hTel22 are attributed to the preferred metal coordination geometry and the presence of axial ligands.
  • Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials. [Journal Article]
    ACS Appl Mater Interfaces. 2013 Aug 14; 5(15):7509-16.Chu HL, Cheng TM, … Chang CC
  • To develop a drug delivery system (DDS), it is critical to address challenging tasks such as the delivery of hydrophobic and amphiphilic compounds, cell uptake, and the metabolic fate of the drug delivery carrier. Low-density lipoprotein (LDL) has been acknowledged as the human serum transporter of natively abundant lipoparticles such as cholesterol, triacylglycerides, and lipids. Apolipoprotein …
  • Silver indium diphosphate, AgInP(2)O(7). [Journal Article]
    Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 18; 67(Pt 1):i2.Zouihri H, Saadi M, … El Ammari L
  • Polycrystalline material of the title compound, AgInP(2)O(7), was synthesized by traditional high-temperature solid-state methods and single crystals were grown from the melt of a mixture of AgInP(2)O(7) and B(2)O(3) as flux in a platinium crucible. The structure consists of InO(6) octa-hedra, which are corner-shared to PO(4) tetra-hedra into a three-dimensional network with hexa-gonal channels r…
  • Genetic variants of IL-6 and its receptor are not associated with schizophrenia in Taiwan. [Journal Article]
    Neurosci Lett. 2010 Jan 14; 468(3):330-3.Liu YL, Liu CM, … Hwu HG
  • The pathophysiological process of schizophrenia is still unclear. The levels of interleukine-6 (IL-6) and its receptor, soluble IL-6R, have been reported to be elevated in the plasma and cerebrospinal fluid of schizophrenic patients. In this study, we tested the association of genetic variants of IL-6 and IL-6R with schizophrenia. Genotyping of three single nucleotide polymorphisms (SNP) for each…
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