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Unbound Medicine.
(Apo Thioridazine)
3,275 results
  • Active inference, morphogenesis, and computational psychiatry. [Journal Article]
    Front Comput Neurosci. 2022; 16:988977.Pio-Lopez L, Kuchling F, … Levin M
  • Active inference is a leading theory in neuroscience that provides a simple and neuro-biologically plausible account of how action and perception are coupled in producing (Bayes) optimal behavior; and has been recently used to explain a variety of psychopathological conditions. In parallel, morphogenesis has been described as the behavior of a (non-neural) cellular collective intelligence solving…
  • Drugs and Lactation Database (LactMed): Thioridazine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because there is no published experience with thioridazine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
  • Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity. [Review]
    Biomolecules. 2022 09 29; 12(10)Chiang TK, White KM, … Yu M
  • It is important for clinicians to consider exposure to toxic substances and nutritional deficiencies when diagnosing and managing cases of vision loss. In these cases, physiologic damage can alter the function of key components of the visual pathway before morphologic changes can be detected by traditional imaging methods. Electrophysiologic tests can aid in the early detection of such functional…
  • The role of phenothiazine derivatives in autophagy regulation: A systematic review. [Review]
    J Appl Toxicol. 2022 Sep 27 [Online ahead of print]Otręba M, Stojko J, Rzepecka-Stojko A
  • In this review, we summarized the current literature on the impact of phenothiazine derivatives on autophagy in vitro. Phenothiazines are antipsychotic drugs used in the treatment of schizophrenia, which is related to altered neurotransmission and dysregulation of neuronal autophagy. Thus, phenothiazine derivatives can impact autophagy. We identified 35 papers, where the use of the phenothiazines…
  • The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma. [Journal Article]
    J Invest Dermatol. 2023 Feb; 143(2):305-316.e5.Lasheras-Otero I, Feliu I, … Arozarena I
  • Circulating tumor cells are the key link between a primary tumor and distant metastases, but once in the bloodstream, loss of adhesion induces cell death. To identify the mechanisms relevant for melanoma circulating tumor cell survival, we performed RNA sequencing and discovered that detached melanoma cells and isolated melanoma circulating tumor cells rewire lipid metabolism by upregulating fatt…
  • StatPearls: Deadly Single Dose Agents [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EuwemaMichael S.MSOrange Park Medical CenterSwansonTerrell J.TJOrange Park Medical CenterBOOK
  • Although the basics of evaluating and treating most unknown ingestants are well known, many overdoses require very specific treatment if the patient is to have any chance of survival.[1] Countless studies have been published supporting Dr. Gideon Koren's 1993 landmark article "Medications Which Can Kill a Toddler with One Tablet or Teaspoonful" in the Journal of Toxicology.[2][3][4][5] while each…
  • Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats. [Journal Article]
    Front Behav Neurosci. 2022; 16:934834.Yang M, Fu Q, … Li B
  • Risky decision-making is the decision made by individuals when they know the probability of each outcome. In order to survive in unpredictable environments, it is necessary for individuals to assess the probability of events occurring to an make appropriate decisions. There are few studies on the neural basis of risky decision-making behavior guided by external cues, which is related to the relat…
  • Screening for inhibitors against SARS-CoV-2 and its variants. [Journal Article]
    Biosaf Health. 2022 Jun; 4(3):186-192.Yuan W, Dong X, … Wang J
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, generating new variants that pose a threat to global health; therefore, it is imperative to obtain safe and broad-spectrum antivirals against SARS-CoV-2 and its variants. To this end, we screened compounds for their ability to inhibit viral entry, which is a critical step in virus infection. Twenty compounds that ha…
  • Antipsychotic drug waste: A potential corrosion inhibitor for mild steel in the oil and gas industry. [Journal Article]
    Waste Manag. 2022 May 15; 145:38-47.Bobby Kannan M, Rahuma M, … Melchers R
  • In this study, the corrosion inhibition efficiency of thioridazine hydrochloride (TH), an antipsychotic drug, on mild steel (commonly used pipeline material in the oil and gas industry) in 1 M hydrochloric acid (HCl) was evaluated using electrochemical techniques and weight loss method. Electrochemical impedance spectroscopy (EIS) results suggest that TH significantly enhances the polarization re…
  • StatPearls: Thioridazine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)FeinbergShana M.SMFaribaKamronKUniversity HospitalSaadabadiAbdolrezaAWestern University/ Kaweah DeltaBOOK
  • Similar to other first-generation or typical antipsychotics, thioridazine is a medication used to treat schizophrenia. Other indications for use include other psychotic disorders, depressive disorders, pediatric behavioral disorders, and geriatric psychoneurotic manifestations. This activity outlines the indications, mechanism of action, administration methods, significant adverse effects, contra…
  • Thioridazine Enhances Cisplatin-Induced DNA Damage in Cisplatin-Resistant Human Lung Cancer Cells. [Journal Article]
    Evid Based Complement Alternat Med. 2022; 2022:3702665.Luo Y, Yu T, … Qian G
  • Thioridazine was used to sensitize cisplatin against cisplatin-resistant human lung cancer cells. Cells received thioridazine, cisplatin, or both drugs (the combination). Thioridazine synergized cisplatin to increase percentages of dead and apoptotic cells. DNA damage was detected using the comet assays; the combination led to the highest alkaline- and neutral-comet percentages, demonstrating exa…
  • Priming with biocides: A pathway to antibiotic resistance? [Journal Article]
    J Appl Microbiol. 2022 Aug; 133(2):830-841.Adkin P, Hitchcock A, … Walsh SE
  • CONCLUSIONS: These findings demonstrate that sub-inhibitory concentrations of biocides can prime bacteria to become resistant to antibiotics even in the absence of stable biocide tolerance and suggests activation of efflux mechanisms may be a contributory factor.
  • Photosensitizing drug reactions. [Review]
    Clin Dermatol. 2022 Jan-Feb; 40(1):57-63.Montgomery S, Worswick S
  • Photosensitizing drug reactions are cutaneous eruptions that occur after exposure to ultraviolet radiation in patients using photosensitizing medications. The reactions can be broadly classified into phototoxic and photoallergic, with the former being much more common and well documented. There is an extensive list of photosensitizing medications, especially in the case of phototoxicity. The most…
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