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Unbound Medicine.
(Apo Triazo)
1,808 results
  • Non-Steroidal Drug Interferences in a Quantitative Multisteroid LC-MS/MS Assay. [Journal Article]
    Cells. 2023 Jan 15; 12(2)Braun V, Stuppner H, Seger C
  • Screening for possible interferences from steroidal compounds other than the target analytes (endogenous or exogenous) is well established in LC-MS/MS assay development for steroid quantification in a routine clinical setting. However, interferences from non-steroidal substances have, hitherto, not been explored. After screening more than 150 pharmaceuticals and their metabolites by analyzing com…
  • StatPearls: Prescription of Controlled Substances: Benefits and Risks [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)PreussCharles V.CVUniversity of South FloridaKalavaArunAUniversity of South FloridaKingKevin C.KCBOOK
  • One of the single most difficult challenges for any prescriber is to distinguish between the legitimate prescription of controlled substances versus the prescription potentially used for illegitimate purposes. To discern the difference, prescribers need to understand the signs, symptoms, and treatment of acute and chronic pain as well as the signs and symptoms of patients misusing controlled subs…
  • Axial chirality and affinity at the GABAA receptor of triazolobenzodiazepines. [Journal Article]
    Bioorg Med Chem. 2022 06 15; 64:116758.Tanaka R, Makino K, … Takahashi H
  • Triazolobenzodiazepines substituted with a methyl group at the C1- and C10-positions and chloro group at C2' of pendant-phenyl were prepared and their physicochemical properties were investigated. The atropisomers of 1,10-disubstituted triazolobenzodiazepines, 1d and 1f, were isolated as (a1R, a2S) and (a1S, a2R) isomers. Their absolute configurations were determined on the basis of CD spectra in…
  • Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs. [Journal Article]
    Drug Metab Dispos. 2022 06; 50(6):741-749.Wu Q, Hu Y, … Lan K
  • Cytochrome P450 3A (CYP3A), the most important class of drug-metabolizing enzymes, participates in the metabolism of half of clinically used drugs. The CYP3A index reactions of dogs, one of the most widely used preclinical nonrodent species, are still poorly understood. This work evaluated the activity and selectivity of 10 CYP3A index reactions, including midazolam (MDZ) 1'- and 4-hydroxylation,…
  • In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice. [Journal Article]
    Xenobiotica. 2021 Jul; 51(7):764-770.Minegishi G, Kazuki Y, … Kobayashi K
  • It is important to predict drug-drug interactions via inhibition of intestinal cytochrome P450 3A (CYP3A) which is a determinant of bioavailability of orally administered CYP3A substrates. However, inhibitory effects of macrolide antibiotics on CYP3A-mediated metabolism are not entirely identical between humans and rodents.We investigated the effects of macrolide antibiotics, clarithromycin and e…
  • Novel and Nonroutine Benzodiazepines and Suvorexant by LC-MS-MS. [Journal Article]
    J Anal Toxicol. 2021 May 14; 45(5):462-474.Garcia L, Tiscione NB, … Richards-Waugh L
  • Benzodiazepines are a commonly prescribed class of drugs that have the potential for abuse. The Palm Beach County Sheriff's Office received drug seizure submissions that included novel and/or nonroutine benzodiazepines of increasing prevalence from 2017 to 2019. This prompted the development of a method of analysis for these compounds in biological specimens. The method tests for 16 novel and non…
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