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(Apo Trifluoperazine)
5,231 results
  • Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer. [Journal Article]
    Toxicol In Vitro. 2023 Jan 23 [Online ahead of print]Mahapatra KK, Mishra SR, … Bhutia SK
  • Aberrant expression of various genes is associated with the progression of oral squamous cell carcinoma. Stonin 2, an endocytic protein, has a prominent role in clathrin-associated endocytosis. Its position in oral cancer is still unknown. Here, we report that STON2 expression increases with an increase in the grade of the oral cancer tissue. Further, STON2 overexpressed cells possess a higher ra…
  • Multilevel Pharmacological Effects of Antipsychotics in Potential Glioblastoma Treatment. [Journal Article]
    Curr Top Med Chem. 2023 Jan 02 [Online ahead of print]Awuah WA, Kalmanovich J, … Alexiou A
  • Glioblastoma Multiforme (GBM) is a debilitating type of brain cancer with a high mortality rate. Despite current treatment options such as surgery, radiotherapy, and the use of temozolomide and bevacizumab, it is considered incurable. Various methods, such as drug repositioning, have been used to increase the number of available treatments. Drug repositioning is the use of FDA-approved drugs to t…
  • Drugs and Lactation Database (LactMed): Trifluoperazine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Limited information indicates that maternal doses of trifluoperazine up to 10 mg daily do not affect the breastfed infant. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. A safety scoring system finds trifluoperazine to be not recommended during breastfeeding.[1] Because there is little published experience with trifluopera…
  • Markov state modelling reveals heterogeneous drug-inhibition mechanism of Calmodulin. [Journal Article]
    PLoS Comput Biol. 2022 10; 18(10):e1010583.Westerlund AM, Sridhar A, … Delemotte L
  • Calmodulin (CaM) is a calcium sensor which binds and regulates a wide range of target-proteins. This implicitly enables the concentration of calcium to influence many downstream physiological responses, including muscle contraction, learning and depression. The antipsychotic drug trifluoperazine (TFP) is a known CaM inhibitor. By binding to various sites, TFP prevents CaM from associating to targ…
  • The role of phenothiazine derivatives in autophagy regulation: A systematic review. [Review]
    J Appl Toxicol. 2022 Sep 27 [Online ahead of print]Otręba M, Stojko J, Rzepecka-Stojko A
  • In this review, we summarized the current literature on the impact of phenothiazine derivatives on autophagy in vitro. Phenothiazines are antipsychotic drugs used in the treatment of schizophrenia, which is related to altered neurotransmission and dysregulation of neuronal autophagy. Thus, phenothiazine derivatives can impact autophagy. We identified 35 papers, where the use of the phenothiazines…
  • Bioanalysis of trifluoperazine in human plasma by LC-MS/MS: Application to disposition kinetics. [Journal Article]
    Biomed Chromatogr. 2022 Dec; 36(12):e5499.Bezawada V, Mogili P, … Ponnada S
  • A sensitive, selective and rapid bioanalytical method using liquid chromatography-tandem mass spectrometry has been developed for the quantification of trifluoperazine in human plasma. Trifluoperazine-D8 was used as the internal standard and the extraction from human plasma was performed by liquid-liquid extraction technique using tertiary butyl methyl ether as the solvent. Chromatographic separa…
  • Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia. [Journal Article]
    Brain. 2022 Aug 27 [Online ahead of print]Vantaggiato C, Orso G, … Teresa Bassi M
  • SPG15 is a hereditary spastic paraplegia (HSP) subtype caused by mutations in Spastizin, a protein encoded by the ZFYVE26 gene. Spastizin is involved in autophagosome maturation and autophagic lysosome reformation (ALR) and SPG15-related mutations lead to ALR defects with lysosome enlargement, free lysosomes depletion and autophagosome accumulation. Symptomatic and rehabilitative treatments are t…
  • Inhibition of dengue virus infection by trifluoperazine. [Journal Article]
    Arch Virol. 2022 Nov; 167(11):2203-2212.Piccini LE, Castilla V, Damonte EB
  • Dengue virus (DENV), a member of the genus Flavivirus, family Flaviviridae, is the most widespread viral pathogen transmitted to humans by mosquitoes. Despite the increased incidence of DENV infection, there are no antiviral drugs available for treatment or prevention. Phenothiazines are heterocyclic compounds with various pharmacological properties that are very adaptable for drug repurposing. I…
  • An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol. [Review]
    PLoS One. 2022; 17(6):e0269772.Garakani A, Freire RC, … Perez-Rodriguez MM
  • Anxiety disorders, including panic disorder (PD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), agoraphobia, and specific phobia, are among the most common psychiatric disorders. Although the traditional pharmacologic treatments for anxiety included barbiturates and then benzodiazepines, the introduction of tricyclic antidepressants, followed by the selective serotonin reupta…
  • Screening for inhibitors against SARS-CoV-2 and its variants. [Journal Article]
    Biosaf Health. 2022 Jun; 4(3):186-192.Yuan W, Dong X, … Wang J
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, generating new variants that pose a threat to global health; therefore, it is imperative to obtain safe and broad-spectrum antivirals against SARS-CoV-2 and its variants. To this end, we screened compounds for their ability to inhibit viral entry, which is a critical step in virus infection. Twenty compounds that ha…
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