- Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study. [Journal Article]
- JCJ Clin Psychopharmacol 2018 Jun 12
- CONCLUSIONS: This observational study demonstrates a harmful association between the incidence of Parkinson disease or associated EPSs and use of the antidepressants duloxetine, mirtazapine, citalopram, escitalopram, paroxetine, sertraline, venlafaxine, bupropion, and fluoxetine.
- Chemiluminescence of copper nanoclusters and its application for trihexyphenidyl hydrochloride detection. [Journal Article]
- LLuminescence 2018 May 21
- Chemiluminescence (CL) of copper nanoclusters (CuNCs) induced by cerium (IV) (Ce(IV)) or potassium permanganate (KMnO4 ) in acidic medium was observed. The potential application of CuNCs CL in analyt...
Chemiluminescence (CL) of copper nanoclusters (CuNCs) induced by cerium (IV) (Ce(IV)) or potassium permanganate (KMnO4 ) in acidic medium was observed. The potential application of CuNCs CL in analytical chemistry was also demonstrated using trihexyphenidyl hydrochloride (THP) as an example based on its enhancing CL intensity for the CuNCs-Ce(IV)/KMnO4 systems. The excited state of the CuNCs acted as a luminophore in the CuNCs-Ce(IV) system, while CuNCs played the role of reductant in the CuNCs-KMnO4 system. The increased CL intensity for Ce(IV)-CuNCs system was proportional to the THP concentrations in the range of 0.1 to 10.0 μM. The detection limit was 49.0 nM and the relative standard deviation was 2.2% for 2.0 μM THP (n = 11). The proposed method was applied to detect THP in pharmaceutical formulations and human plasma samples.
- [Psychoactive substances use in Réunion Island and Mayotte, French departments in Indian Ocean]. [Journal Article]
- TTherapie 2018 Feb 27
- CONCLUSIONS: It is important to report new or serious cases to better take into account the particularities of these two departments in the French addictovigilance data and to enable analysis of substances consumed.
- Trihexyphenidyl for dystonia in cerebral palsy. [Review]
- CDCochrane Database Syst Rev 2018 May 15; 5:CD012430
- CONCLUSIONS: At present, there is insufficient evidence regarding the effectiveness of trihexyphenidyl for people with cerebral palsy for the outcomes of: change in dystonia, adverse effects, increased upper limb function and improved participation in activities of daily living. The study did not measure pain or quality of life. There is a need for larger randomised, controlled, multicentre trials that also examine the effect on pain and quality of life in order to determine the effectiveness of trihexyphenidyl for people with cerebral palsy.
- Misuse of Trihexyphenidyl (Artane) on Réunion Island. [Journal Article]
- JCJ Clin Psychopharmacol 2018; 38(3):250-253
- CONCLUSIONS: This cohort describing the clinical characteristics of 69 patients is the largest cohort studied for THP addiction. Patients from the Centres for Addiction Prevention and Treatment were the youngest and most recently addicted, whereas general practice patients had been addicted for longer and were more socially integrated. This clinical description of THP addiction therefore enables us to identify the patients who are the most at risk, to set up an adapted care protocol.
- Pharmacological and neurosurgical interventions for managing dystonia in cerebral palsy: a systematic review. [Review]
- DMDev Med Child Neurol 2018; 60(4):356-366
- To systematically review evidence for pharmacological/neurosurgical interventions for managing dystonia in individuals with cerebral palsy (CP) to inform a care pathway.
To systematically review evidence for pharmacological/neurosurgical interventions for managing dystonia in individuals with cerebral palsy (CP) to inform a care pathway.
- Prescribing Pattern for Parkinson's Disease in Indian Community before Referral to Tertiary Center. [Journal Article]
- CJCan J Neurol Sci 2017; 44(6):705-710
- CONCLUSIONS: Levodopa and trihexyphenidyl were the most commonly prescribed drugs in our patients. A higher use of trihexyphenidyl could be due to its easy availability, low cost, and better tolerability in our patients, who were relatively young at the time of onset of their disease. The choice of antiparkinsonian medications at the primary and secondary care levels in India may be inappropriate, and newer guidelines tailored to the Indian context are warranted.
- Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report. [Case Reports]
- MMedicine (Baltimore) 2017; 96(47):e8711
- CONCLUSIONS: Considering the wide and long-term utilization of VPA and LTG, healthcare providers should be aware of them as a possible cause of tremor. When necessary, an attempt of discontinuing the suspected drugs should be made to confirm the diagnosis, instead of symptomatic treatment, especially when the adverse event was severe and fatal.
- Progressive delayed hemidystonia following clinically mild traumatic brain injury. [Journal Article]
- BCBMJ Case Rep 2017 Dec 28; 2017
- A 16-year-old boy presented with progressive left hemidystonia over 3 years. The possibilities of symptomatic hemidystonia due to focal lesions such as infarct (vasculitis), tumours, tuberculoma, art...
A 16-year-old boy presented with progressive left hemidystonia over 3 years. The possibilities of symptomatic hemidystonia due to focal lesions such as infarct (vasculitis), tumours, tuberculoma, arteriovenous malformations or heredodegenerative disorders such as Wilson disease were considered. Imaging showed a peculiar scar involving right basifrontal region extending upto anterior, centromedian and dorsomedial nuclei of thalamus due to blowout fracture of roof of orbit. This scar was responsible for progressive left hemidystonia. On probing the history, it was revealed that patient had sustained a mild traumatic brain injury (mTBI) 3 years ago. Burke-Fahn-Marsden dystonia severity rating scale showed improvement from 19 to 6 after treatment with tablet trihexyphenidyl 16 mg and clonazepam 1 mg. A linear scar reaching upto thalamus due to blowout fracture of roof of orbit following clinically mTBI is unique. Delayed, progressive hemidystonia has been reported following severe head injury, however is less common following clinically mTBI.
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- Successful Use of Risperidone, Trihexyphenidyl, and Paroxetine in Pregnancy. [Journal Article]
- IJIndian J Psychol Med 2017 Nov-Dec; 39(6):835-836