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1,154 results
  • Pharmacological and neurosurgical interventions for managing dystonia in cerebral palsy: a systematic review. [Journal Article]
  • DMDev Med Child Neurol 2018 Feb 06
  • Fehlings D, Brown L, … Walters I
  • CONCLUSIONS: For dystonia reduction, ITB and DBS are possibly effective, whereas trihexyphenidyl was possibly ineffective. There is insufficient evidence to support oral medications or botulinum toxin to reduce dystonia. There is insufficient evidence for pharmacological and neurosurgical interventions to improve motor function, decrease pain, and ease caregiving. The majority of the pharmacological and neurosurgical management of dystonia in CP is based on clinical expert opinion.Intrathecal baclofen and deep brain stimulation are possibly effective in reducing dystonia. Current evidence does not support effectiveness of oral medications or botulinum toxin to reduce dystonia. Evidence is inadequate for pharmacological/neurosurgical interventions impact on improving motor function, pain/comfort, and easing caregiving. The majority of the care pathway rests on expert opinion.
  • Prescribing Pattern for Parkinson's Disease in Indian Community before Referral to Tertiary Center. [Journal Article]
  • CJCan J Neurol Sci 2017; 44(6):705-710
  • Surathi P, Kamble N, … Pal PK
  • CONCLUSIONS: Levodopa and trihexyphenidyl were the most commonly prescribed drugs in our patients. A higher use of trihexyphenidyl could be due to its easy availability, low cost, and better tolerability in our patients, who were relatively young at the time of onset of their disease. The choice of antiparkinsonian medications at the primary and secondary care levels in India may be inappropriate, and newer guidelines tailored to the Indian context are warranted.
  • Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report. [Case Reports]
  • MMedicine (Baltimore) 2017; 96(47):e8711
  • He ZF, Chen J, … Wang XH
  • CONCLUSIONS: Considering the wide and long-term utilization of VPA and LTG, healthcare providers should be aware of them as a possible cause of tremor. When necessary, an attempt of discontinuing the suspected drugs should be made to confirm the diagnosis, instead of symptomatic treatment, especially when the adverse event was severe and fatal.
  • [Drug-Induced Akathisia]. [Journal Article]
  • BNBrain Nerve 2017; 69(12):1417-1424
  • Inada T
  • Akathisia consists of subjective inner restlessness, such as awareness of the inability to remain seated, restless legs, fidgetiness, and the desire to move constantly, and of objective increased mot...
  • An unusual presentation of tyrosine hydroxylase deficiency. [Journal Article]
  • JCJ Clin Mov Disord 2017; 4:18
  • Katus LE, Frucht SJ
  • CONCLUSIONS: TH deficiency can cause a broad range of clinical symptoms and severity. As more cases are discovered, the phenotype expands. Here we describe a unique case of DRD and possible parkinsonism due to TH deficiency with residual symptoms of dystonia that was task dependent and responded to a sensory trick. In addition, while the history is limited, it is possible he may have had episodes similar to "lethargy-irritability crises" seen in more severe cases. In large part he fits within the milder form of TH hydroxylase deficiency.
  • Efficacy of oral pharmacological treatments in dyskinetic cerebral palsy: a systematic review. [Review]
  • DMDev Med Child Neurol 2017; 59(12):1237-1248
  • Masson R, Pagliano E, Baranello G
  • CONCLUSIONS: This lack of evidence is partially owing to the inconsistency of classifications of patients and of outcome measures used in the reviewed studies. Further randomized, double-blind, placebo-controlled pharmacological trials, optimized for different age groups, based on valid, reliable, and disease-specific rating scales are strongly needed. Outcome measures should be selected within the framework of the International Classification of Functioning, Disability and Health.Evidence to prove (or disprove) the efficacy of oral drugs in dyskinetic cerebral palsy is low. The most investigated drugs, trihexyphenidyl and levodopa, show contradictory results. Tetrabenazine, levetiracetam, and gabapentin efficacy should be studied in more detail. Lack of evidence is partially due to the inconsistency of classifications and outcome measures used. Outcome measures should be selected within the framework of the International Classification of Functioning, Disability and Health in next clinical trials.
  • GeneReviews® [BOOK]
  • BOOKUniversity of Washington, Seattle: Seattle (WA)
  • Adam MP, Ardinger HH, … Amemiya AGregory A, Hayflick SJ
  • Pantothenate kinase-associated neurodegeneration (PKAN) is a type of neurodegeneration with brain iron accumulation (NBIA). The phenotypic spectrum of PKAN includes classic PKAN and atypical PKAN. Cl...
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