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Unbound Medicine.
(Apo Zidovudine)
12 results
  • Structural basis of HIV-1 resistance to AZT by excision. [Journal Article]
    Nat Struct Mol Biol. 2010 Oct; 17(10):1202-9.Tu X, Das K, … Arnold E
  • Human immunodeficiency virus (HIV-1) develops resistance to 3'-azido-2',3'-deoxythymidine (AZT, zidovudine) by acquiring mutations in reverse transcriptase that enhance the ATP-mediated excision of AZT monophosphate from the 3' end of the primer. The excision reaction occurs at the dNTP-binding site, uses ATP as a pyrophosphate donor, unblocks the primer terminus and allows reverse transcriptase …
  • Monitoring the intracellular metabolism of nucleoside phosphoramidate pronucleotides by 31P NMR. [Journal Article]
    Nucleosides Nucleotides Nucleic Acids. 2004; 23(1-2):483-93.Kim J, Drontle DP, Wagner CR
  • The intracellular metabolism of 3'-azido-3'-deoxythymidine (AZT)-(L)-tryptophan methyl ester phosphoramidate (L-ATO) and AZT-(L)-phenylalanine methyl ester phosphoramidate (L-APO) by the human T-lymphoblastoid cell line CCRF-CEM (CEM-1.3) and peripheral blood mononuclear cell line (PBMC) was investigated with high field 31P NMR spectroscopy. The AZT amino acid phosphoramidates were shown to accum…
  • Protection by protein A of apoptotic cell death caused by anti-AIDS drug zidovudine. [Journal Article]
    Biochem Biophys Res Commun. 1999 Oct 22; 264(2):601-4.Ghosh AK, Jana S, … Ray PK
  • Zidovudine, the anti-AIDS drug, caused inhibition of mitogen-induced proliferation and perturbation of cell-cycle progression of cultured bone marrow cells of mice. There was significant hypoploidy observed in flow cytometric analysis of AZT-treated bone marrow cells. In apo-direct analysis, cells showed apoptosis in G0/G1 phase. In DNA gel analysis, characteristic laddering of apoptosis was obse…
  • Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells. [Case Reports]
    Blood. 1998 May 15; 91(10):3935-42.Tamiya S, Etoh K, … Matsuoka M
  • CD95 antigen (also known as Fas or Apo-1) and Fas ligand play key roles in apoptosis of cells of the immune system, function as effector molecules of cytotoxic T lymphocytes, and function in the elimination of activated lymphocytes during the downregulation of the immune response. The critical roles of the Fas-Fas ligand system in apoptosis suggest that its inactivation may be involved in maligna…
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