- Construction of compostable packaging with antibacterial property and improved performance using sprayed coatings of modified cellulose nanocrystals. [Journal Article]Carbohydr Polym. 2023 Apr 01; 305:120539.CP
- Increasing concerns about food safety and the environment have facilitated the development of eco-friendly antibacterial packaging. This study aimed to demonstrate a facile way to fabricate active packaging materials with modified cellulose nanocrystals (CNCs) and compare the effects of different modified CNCs on the performance of compostable materials. Polylactic acid (PLA) film was selected as…
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- Advances in organic fluorescent probes for bromide ions, hypobromous acid and related eosinophil peroxidase-A review. [Review]Anal Chim Acta. 2023 Mar 01; 1244:340626.AC
- Elemental bromine is among the essential elements for human health. In living organisms, bromide (Br-) and hydrogen peroxide (H2O2) can be catalyzed by eosinophil peroxidase (EPO) to generate a reactive oxygen species (ROS), hypobromous acid (HOBr), which exhibits properties similar to those of hypochlorous acid (HOCl). Moreover, HOBr possesses strong oxidative and antibacterial properties, which…
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- Investigation on the formation mechanism of main products from TBBPA pyrolysis using DFT method. [Journal Article]Chemosphere. 2023 Feb 01 [Online ahead of print]C
- The formation mechanisms of the main pyrolysis products of tetrabromobisphenol A (TBBPA) such as hydrogen bromide (HBr), bisphenol A compounds, and phenolic compounds were studied through using density functional theory (DFT) method at the theoretical level of B3P86/6-311 + G (d,p), and the effects of H and Br radicals on the formation mechanism of each product were analyzed. For the formation of…
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- HPLC-UV/VIS for Determination of Ipratropium Bromide Mixed with Salbuterol, Beclomethasone Propionate and Budesonide using Dual Wavelength-Detection Method. [Journal Article]Drug Res (Stuttg). 2023 Feb 03 [Online ahead of print]DR
- CONCLUSIONS: The liquid phase methodology developed in this study can be used for the determination of compound ipratropium bromide mixed with beclomethasone propionate and budesonide. The current methodology can also be used to provide a reference for the determination of its content after mixing, and further data support for its clinical medication.
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- A New Motif in Halogen Bonding: Cooperative Intermolecular S-Br···O, O···F, and F···F Associations in the Crystal Packing of α,ω-Di(sulfonyl bromide) Perfluoroalkanes. [Journal Article]Chem Asian J. 2023 Feb 03 [Online ahead of print]CA
- We recently reported the first examples of S-Cl···O halogen bonding complemented by short F···F contacts between neighboring chains that resulted in stabilized crystals of ClSO2(CF2)4SO2Cl and ClSO2(CF2)6SO2Cl. More recently, other researchers studied our crystallographic data further using an Independent Gradient Model (IGM), and they suggested if one goes beyond IUPAC's proposed 'less than the…
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- Neuroprotective effects of Geranium Robertianum L. Aqueous extract on the cellular Parkinson's disease model. [Journal Article]Eur Rev Med Pharmacol Sci. 2023 Jan; 27(2):570-579.ER
- CONCLUSIONS: The current findings could lead to a promising new candidate for a possible cure of Parkinson's disease through neuroprotective mechanisms with respect to antioxidant and apoptosis inhibitory properties of G. Robertianum water extracts.
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- Circular RNA circ_0003028 regulates cell development through modulating miR-498/ornithine decarboxylase 1 axis in hepatocellular carcinoma. [Journal Article]Anticancer Drugs. 2022 Nov 21 [Online ahead of print]AD
- Circular RNA has been revealed to participate in multiple biological functions and contribute to various diseases' progression. This study aims to clarify the role of circ_0003028 and its potential molecular mechanism in hepatocellular carcinoma (HCC). The levels of circ_0003028, miR-498, and ornithine decarboxylase 1 (ODC1) mRNA were examined by quantitative real-time PCR. The cell proliferation…
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- A novel ribociclib derivative WXJ-103 exerts anti-breast cancer effect through CDK4/6. [Journal Article]Anticancer Drugs. 2022 Dec 19 [Online ahead of print]AD
- The triple-negative breast cancer (TNBC) subtype is the most aggressive type of breast cancer with a low survival prognosis and high recurrence rate. There is currently no effective treatment to improve it. In this work, we explored the effect of a synthetic compound named WXJ-103 on several aspects of TNBC biology. The human breast cancer cell lines MDA-MB-231 and MCF-7 were used in the experime…
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- Growth differentiation factor 15 is required for triple-negative breast cancer cell growth and chemoresistance. [Journal Article]Anticancer Drugs. 2022 Dec 23 [Online ahead of print]AD
- Growth differentiation factor 15 (GDF15) is a pleiotropic cytokine, which is involved in the cellular stress response following acute damage. However, the functional role of GDF15 in triple-negative breast cancer (TNBC) has not been fully elucidated. ELISA, Western blot, and PCR assays as well as bioinformatics analyses were conducted to observe the expression of GDF15. Cell Counting Kit-8, 3-(4,…
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- Single-step assembly of lipid-gelatin-epigallocatechin-3-gallate hybrid nanoparticles for cancer therapy. [Journal Article]Anticancer Drugs. 2022 Dec 23 [Online ahead of print]AD
- CONCLUSIONS: Our study highlights the unique EGCG-entrapped lipid-gelatin hybrid nanoparticles, which may be a powerful strategy for further cancer therapy.
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- Directing oxygen reduction reaction selectivity towards hydrogen peroxide via electric double layer engineering. [Journal Article]Nanoscale. 2023 Feb 02 [Online ahead of print]N
- The electrochemical oxygen reduction reaction (ORR) has been recognized as a promising alternative for the sustainable production of H2O2. Here, we report a facile and effective strategy to promote ORR selectivity towards the 2e- product H2O2via electric double layer engineering. Specifically, in a model system using immobilized cobalt phthalocyanine as the electrocatalyst, H2O2 selectivity has b…
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- Visiblelight-induced ternary electron donor-acceptor complex enabled synthesis of 2-(2-hydrazinyl) thiazole derivatives and the assessment of their antioxidant and antidiabetic therapeutic potential. [Journal Article]Org Biomol Chem. 2023 Feb 02 [Online ahead of print]OB
- A mild and eco-friendly visible-light-induced synthesis of 2-(2-hydrazinyl) thiazole from readily accessible thiosemicarbazide, carbonyl, and phenacyl bromide in the absence of a metal catalyst and/or any extrinsic photosensitizer is reported. This approach only requires a source of visible light and a green solvent at room temperature to produce the medicinally privileged scaffolds of hydrazinyl…
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- [Simultaneous determination of triclosan,triclocarban and p-chloro-m-xylenol in disinfectant,personal care products and oiltment by nonaqueous capillary electrophoresis]. [Journal Article]Se Pu. 2023 Feb; 41(2):168-177.SP
- Triclosan (TCS), triclocarban (TCC), and p-chloro-m-xylenol (PCMX) are some of the most widely used antibiotics because of their broad-spectrum and highly-efficient bactericidal effects. In the context of disinfection, the National Standard GB 38598-2020 stipulates that the contents of the effective ingredients present in a disinfectant must be specified, wherein their range must fall within 90%-…
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- Phenotypic ESBL and non-phenotypic ESBL isolates of Klebsiella pneumoniae exhibit differing responses to induced antimicrobials resistance and subsequent antibiotic cross-resistance. [Journal Article]J Appl Microbiol. 2022 Dec 19 [Online ahead of print]JA
- CONCLUSIONS: The extensive use of biocides in the environment can induce cross-resistance to other biocides and antibiotics, and can increase the ability of bacteria to form biofilms. The response of bacteria to biocide adaptation differs between pESBL and npESBL isolates, although the effect is strain specific.
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- Photoinduced Nickel-Catalyzed Selective N-Demethylation of Trialkylamines Using C(sp2)-Bromides as HAT Reagents. [Journal Article]J Am Chem Soc. 2023 Feb 01 [Online ahead of print]JA
- N-Demethylation of trialkylamines is a useful transformation, but typically requires harsh reaction conditions and stepwise procedures, as well as judicious protection of labile functional groups. Herein we report a mild, catalytic approach for the demethylation of trialkylamines by utilizing photoinduced nickel catalysis wherein C(sp2)-bromides serve as hydrogen-atom transfer (HAT) reagents. Thi…
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- Catalytic Cross-Metathesis Reactions That Afford E- and Z-Trisubstituted Alkenyl Bromides: Scope, Applications, and Mechanistic Insights. [Journal Article]J Am Chem Soc. 2023 Feb 01 [Online ahead of print]JA
- Stereochemically defined trisubstituted alkenes with a bromide and a methyl group at a terminus can be readily and stereoretentively derivatized through catalytic cross-coupling, affording unsaturated fragments found in many bioactive natural products. A direct method for generating such entities would be by stereocontrolled catalytic cross-metathesis (CM). Such methods are scarce however. Here, …
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- First worldwide report of Exserohilum rostratum causing leaf spot on strawberry (Fragaria × ananassa Duch.). [Journal Article]Plant Dis. 2023 Feb 01 [Online ahead of print]PD
- During April 2022, leaf spot was observed on strawberry (Fragaria × ananassa Duch.) with a disease incidence of approximately 45% among 100 plants. Strawberry was cultivated in a nursery at Huzhou University (30.87゜N, 120.13゜E), Zhejiang Province, China. In the strawberry greenhouse, the average temperature was 15-18 degrees, 40%-60% humidity. Early symptoms appeared as dark brown or black spotte…
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- EFFICACY OF COMBINATION OF TIOTROPIUM/OLODATEROL IN PATIENTS WITH COPD IN REAL CLINICAL PRACTICE. [Journal Article]Wiad Lek. 2022; 75(12):2953-2957.WL
- CONCLUSIONS: Conclusions: Tiotropium/olodaterol combination showed its efficacy in real clinical practice. There was significant reduction in amount of exacerbation and antibiotic, gluco¬corticosteroid use during the study, which was also accompanied by the reduction is symptoms.
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- Recent progress in the oxidative bromination of arenes and heteroarenes. [Review]Org Biomol Chem. 2023 Jan 31 [Online ahead of print]OB
- Oxidative bromination has been serving as a powerful tool for the synthesis of bromo-containing molecules, as this bromination strategy features environmental friendliness, high flexibility in reaction system design and wide abundance of bromide sources and oxidants. The past decade has witnessed a large number of efficient oxidative bromination reaction systems and novel brominated aromatics. Th…
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- Electrooxidative Activation of B-B Bond in B2cat2: Access to gem-Diborylalkanes via Paired Electrolysis. [Journal Article]Angew Chem Int Ed Engl. 2023 Feb 01 [Online ahead of print]AC
- This report describes the unprecedented electrooxidation of a solvent (e.g., DMF)-ligated B2cat2 complex, whereby a solvent-stabilized boryl radical is formed via quasi-homolytic cleavage of the B-B bond in a DMF-ligated B2cat2 radical cation. Cyclic voltammetry and density functional theory provide evidence to support this novel B-B bond activation strategy. Furthermore, a strategy for the elect…
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- Static and Dynamic Disorder in Formamidinium Lead Bromide Single Crystals. [Journal Article]J Phys Chem Lett. 2023 Jan 31 [Online ahead of print]JP
- We show that formamidinium-based crystals are distinct from methylammonium-based halide perovskite crystals because their inorganic sublattice exhibits intrinsic local static disorder that coexists with a well-defined average crystal structure. Our study combines terahertz-range Raman scattering with single-crystal X-ray diffraction and first-principles calculations to probe the evolution of inor…
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- Additive-Enhanced Crystallization of Inorganic Perovskite Single Crystals for High-Sensitivity X-Ray Detection. [Journal Article]Small. 2023 Jan 31 [Online ahead of print]S
- Inorganic cesium lead halide perovskite single crystals are particularly intriguing to ionizing radiation detection by virtue of their material stability and high attenuation coefficients. However, the growth of high-quality inorganic perovskite single crystals remains challenging, mainly due to the limited solubility. In this work, an additive-enhanced crystallization method is proposed for cesi…
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- In vivo and in vitro toxicity profile of tetrabutylammonium bromide and alcohol-based deep eutectic solvents. [Journal Article]
- Deep eutectic solvents (DESs) have emerged as new promising solvents in the field of "green chemistry," which possess a broad range of potential applications. However, the ecotoxicological profile of these solvents is still poorly known. In this study, ammonium-based deep eutectic solutions with glycerol (2:2), ethylene glycol (1:2), and diethylene glycol (1:2) as hydrogen bond donors in 1:2 prop…
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- Targeted silencing of the MCL-1 gene using multi-layered dendrimer-based nanoconstructs achieves efficient tumor regression in xenografted mice models. [Journal Article]Int J Pharm. 2023 Jan 28 [Online ahead of print]IJ
- The setback in the practical clinical use of RNA interference (RNAi)-based cancer treatment stems from the lack of targeted small interfering RNA (siRNA) delivery. Here, we show that luteinizing hormone-releasing hormone(LHRH) analog-tethered multi-layered polyamidoamine (PAMAM) nanoconstructs silence the anti-apoptotic MCL-1 gene in LHRH receptor overexpressing human breast (MCF-7) and prostate …
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- Organolead Halide-Based Coordination Polymers: Intrinsic Stability and Photophysical Applications. [Journal Article]Acc Chem Res. 2023 Jan 31 [Online ahead of print]AC
- ConspectusOrganolead halide-based photovoltaics are one of the state-of-the-art solar cell systems with efficiencies increasing to 25% over the past decade, ascribed to their high light-absorption coefficient, broad wavelength coverage, tunable band structure, and excellent carrier mobility. Indeed, these optical characteristics are highly demanding in photocatalysis and photoluminescence (PL), w…
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- Copper Powder and Pd(II) Salts Triggered One-Pot Aromatic Halide Homocoupling via a Radical Pathway. [Journal Article]J Org Chem. 2023 Jan 31 [Online ahead of print]JO
- (sp2)C-(sp2)C bond formation is one of the most utilitarian techniques in target synthesis and material and pharmaceutical production. Biaryls usually emerge with the coupling of aryl halides or pseudohalides and require the prepreparation of an organometallic reagent, which results in low efficiency and atomic economy. The classic Ullmann reactions could be adopted to directly synthesize biaryls…
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- Strongly Confined CsPbBr3 Quantum Dots as Quantum Emitters and Building Blocks for Rhombic Superlattices. [Journal Article]ACS Nano. 2023 Jan 31 [Online ahead of print]AN
- The success of the colloidal semiconductor quantum dots (QDs) field is rooted in the precise synthetic control of QD size, shape, and composition, enabling electronically well-defined functional nanomaterials that foster fundamental science and motivate diverse fields of applications. While the exploitation of the strong confinement regime has been driving commercial and scientific interest in In…
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- Evaluation of a vaccine candidate isolated from Cryptosporidium parvum oocyst in mice. [Journal Article]
- CONCLUSIONS: Our prepared affinity-purified vaccine candidate could be promising in protecting against cryptosporidiosis.
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- Heptadecanoic Acid, an Odd-Chain Fatty Acid, Induces Apoptosis and Enhances Gemcitabine Chemosensitivity in Pancreatic Cancer Cells. [Journal Article]J Med Food. 2023 Jan 30 [Online ahead of print]JM
- Odd-chain saturated fatty acids generally serve as specific biomarkers of dietary components and dairy intake, some of which have anticancer properties. This study was performed to assess the anticancer effects of heptadecanoic acid (HDNA) in human pancreatic carcinoma cells. MTT (thiazolyl blue tetrazolium bromide) assay showed that HDNA exerted stronger cytotoxic effects than pentadecanoic acid…
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- Mineral Nanoparticle Aggregation Alters Contaminant Transport under Flow. [Journal Article]Environ Sci Technol. 2023 Jan 30 [Online ahead of print]ES
- Iron oxyhydroxide nanoparticle reactivity has been widely investigated, yet little is still known on how particle aggregation controls the mobility and transport of environmental compounds. Here, we examine how aggregates of goethite (α-FeOOH) nanoparticle deposited on 100-300 μm quartz particles (GagCS) alter the transport of two emerging contaminants and two naturally occurring inorganic ligand…
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