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6,516 results
  • Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis. [Systematic Review]
    Front Pharmacol. 2022; 13:1092501.Deng NJ, Xian-Yu CY, … Zhang C
  • Aims: To evaluate the efficacy of different pharmacologic treatment for severe hypertension during pregnancy. Methods: Two reviewers searched Ovid MEDLINE, Ovid EMbase, and the Cochrane Library for randomized clinical trials from the establishment of the database to 15 July 2021 that were eligible for inclusion and analyzed the pharmaceuticals used for severe hypertension in pregnancy. Results: 2…
  • Neonatal systemic hypertension across the PHIS database: An update. [Journal Article]
    Int J Cardiol. 2023 Jan 19 [Online ahead of print]AlMaazmi A, Hagan J, … Gowda SH
  • CONCLUSIONS: Diagnosis of Systemic hypertension continues to increase in the neonatal population, despite absence of well-defined criteria necessitating targeted medical management. A consensus guideline which addresses this very important condition is beneficial.
  • Management of Heart Failure with Reduced Ejection Fraction. [Review]
    Curr Probl Cardiol. 2023 Jan 18 [Online ahead of print]Rashid AM, Khan MS, … Butler J
  • Heart failure with reduced ejection fraction (HFrEF) is a complex and progressive clinical condition characterized by dyspnea and functional impairment. HFrEF has a high burden of mortality and readmission rate making it one of the most significant public health challenges. Basic treatment strategies include diuretics for symptom relief and use of quadruple therapy (Angiotensin receptor blocker/n…
  • Anti-ageing effects of FDA-approved medicines: a focused review. [Review]
    J Basic Clin Physiol Pharmacol. 2023 Jan 13 [Online ahead of print]Thanapairoje K, Junsiritrakhoon S, … Supharattanasitthi W
  • Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found th…
  • Identification of Human miRNA Biomarkers Targeting the SARS-CoV-2 Genome. [Journal Article]
    ACS Omega. 2022 Dec 20; 7(50):46411-46420.Saha I, Ghosh N, Plewczynski D
  • SARS-CoV-2 poses a great challenge toward mankind, majorly due to its evolution and frequently occurring variants. On the other hand, in human hosts, microRNA (miRNA) plays a vital role in replication and propagation during a viral infection and can control the biological processes. This may be essential for the progression of viral infection. Moreover, human miRNAs can play a therapeutic role in…
  • Aiming at harmony. Comparing and contrasting International HFrEF Guidelines. [Journal Article]
    Eur Heart J Suppl. 2022 Dec; 24(Suppl L):L20-L28.Tomasoni D, Adamo M, … Metra M
  • Large randomized controlled trials (RCTs) have led to major changes in the treatment of patients with heart failure and reduced left ventricular ejection fraction (HFrEF) and these advances are included in the recent European Society of Cardiology (ESC) and the American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA) guidelines issued in 2021 and 2…
  • Hypertensive Conditions: Hypertensive Disorders in Pregnancy. [Journal Article]
    FP Essent. 2022 Nov; 522:25-33.Kipnis CM, Daly PL, … Smith DK
  • Hypertensive disorders in pregnancy (HDP) represent a spectrum of disease that affect women through pregnancy and the immediate postpartum period. These conditions are associated with significant morbidity and mortality during and after pregnancy and have been linked to cardiovascular disease later in life. The HDP spectrum includes gestational hypertension (HTN), preeclampsia, eclampsia, HELLP (…
  • Hydralazine-Induced Lupus Presenting With Pancytopenia: A Case Report. [Case Reports]
    Cureus. 2022 Sep; 14(9):e29793.Brar Y, Yang NR, Poliyedath A
  • Hydralazine-induced lupus leading to pancytopenia is an uncommon presentation and can have systemic effects on the body. We present the case of a 73-year-old male with complaints of fever, night sweats, and non-intentional weight loss. Complete blood count pathology review showed pancytopenia with no blasts. Detailed infectious disease workup, including Coccidioidomycosis and tuberculosis, was ne…
  • Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway. [Journal Article]
    Am J Physiol Heart Circ Physiol. 2022 12 01; 323(6):H1118-H1129.Mukohda M, Mizuno R, … Ozaki H
  • Lymph capillary network can be expected to alter blood pressure via regulating interstitial electrolyte and volume balance. However, the pathophysiology of lymphatic vessel in hypertension is poorly understood. In this study, we examined lymph vessel function focusing on contractile response in hypertensive rats. It was found that thoracic ducts isolated from adult (10-14 wk old) spontaneously hy…
  • Inpatient Quality-of-Care Measures for Heart Failure: Treatment Gaps and Opportunities in the Contemporary Era. [Journal Article]
    Circ Cardiovasc Qual Outcomes. 2022 10; 15(10):e008936.Warner AL, Lu L, … Jackevicius CA
  • CONCLUSIONS: Important inpatient quality of care measures can be readily measured across the Veterans Administration health care system from electronic health records. Treatment gaps and site-level differences persisted into the contemporary era and will likely be exacerbated as newer treatments are added to this complex baseline. These measures and methods also offer the opportunity to target global, local, and individual processes of care for innovative quality improvement initiatives.
  • A review on the clinical pharmacokinetics of hydralazine. [Review]
    Expert Opin Drug Metab Toxicol. 2022 Oct; 18(10):707-714.Shahzad Qamar A, Zamir A, … Rasool MF
  • Hydralazine is a vasodilator used to treat hypertension, pre-eclampsia, and heart failure. The current article reviews the clinical pharmacokinetics (PK) of hydralazine, which can be useful for clinicians in optimizing its dose and dosing frequency to avoid adverse effects and unexpected interactions that could risk patients' lives.
  • A Spotlight on Drug-Induced Vasculitis. [Review]
    Curr Rheumatol Rep. 2022 11; 24(11):323-336.Yaseen K, Nevares A, Tamaki H
  • Drug-induced vasculitis (DIV) is a rare form of vasculitis related to the use of various drugs. DIV primarily affects small to medium size vessels, but it can potentially involve vessels of any size. Differentiating between primary systemic vasculitis and DIV can be challenging; however, it is crucial, so that the offending agent can be discontinued promptly.
  • Hypertensive Crisis in Pregnancy. [Review]
    Obstet Gynecol Clin North Am. 2022 Sep; 49(3):501-519.Wautlet CK, Hoffman MC
  • Severe hypertension in pregnancy is a medical emergency, defined as systolic blood pressure (BP) ≥ 160 mm Hg and/or diastolic BP ≥ 110 mm Hg taken 15 minutes to 4 or more hours apart. Outside pregnancy, acute severe hypertension (HTN) is defined as a BP greater than 180/110 to 120 reproducible on 2 occasions. The lower threshold for severe HTN in pregnancy reflects the increased risk for adverse …
  • Compounded medications for cardiovascular use in neonatology: an integrative review. [Review]
    Rev Paul Pediatr. 2022; 41:e2021167.Greenhalgh LL, Passos MMBD, … Monteiro MSSB
  • CONCLUSIONS: It was possible to analyze the profile of compounded cardiovascular medicines prescribed in neonatology in Brazil. The results showed the need for the development of medications suitable for the neonatal population, and the standardization of operational procedures for preparing extemporaneous formulations in neonatology to increase drug safety.
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