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3,301 results
  • Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]
    Farm Hosp. 2023 Jan 27 [Online ahead of print]Ibarra Barrueta O, García Martín E, … Ais Larisgoitia A
  • CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
  • A New Medical Therapy for Multiple Endocrine Neoplasia Type 1? [Journal Article]
    touchREV Endocrinol. 2022 Nov; 18(2):86-88.Boharoon H, Grossman A
  • Pancreatic neuroendocrine tumours (pNETs) are a major manifestation of multiple endocrine neoplasia type 1 (MEN1), and the most significant cause of morbidity and mortality in this disorder. There is some evidence that the early use of somatostatin analogues can retard progression, especially of small non-functioning tumours, but there are no other prophylactic therapies for patients, and the tre…
  • The Yin-Yang Pharmacomicrobiomics on Treatment Response in Inflammatory Arthritides: A Narrative Review. [Review]
    Genes (Basel). 2022 Dec 28; 14(1)Peretti S, Torracchi S, … Bellando Randone S
  • (1) Background: Gut microbiota (GM) is the set of microorganisms inhabiting the gastroenteric tract that seems to have a role in the pathogenesis of rheumatic diseases. Recently, many authors proved that GM may influence pharmacodynamics and pharmacokinetics of several drugs with complex interactions that are studied by the growing field of pharmacomicrobiomics. The aim of this review is to highl…
  • Broad-scope Syntheses of [11C/18F]Trifluoromethylarenes from Aryl(mesityl)iodonium Salts. [Journal Article]
    Chemistry. 2023 Jan 18 [Online ahead of print]Telu S, Jana S, … Pike VW
  • Efficient methods for labeling aryl trifluoromethyl groups to provide novel radiotracers for use in biomedical research with positron emission tomography (PET) are keenly sought. We report a broad-scope method for labeling trifluoromethylarenes with either carbon-11 (t1/2 = 20.4 min) or fluorine-18 (t1/2 =109.8 min) from readily accessible aryl(mesityl)iodonium salts. In this method, the aryl(mes…
  • Emerging implications for ribosomes in proximity to mitochondria. [Review]
    Semin Cell Dev Biol. 2023 Jan 13 [Online ahead of print]Cohen B, Golani-Armon A, Arava YS
  • Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional site of their encoded protein, enabling local protein synthesis. Studies in various organisms and tissues revealed that such locally translating ribosomes are also present near mitochondria. Here, we provide a …
  • Effect of Leflunomide Use on 68Ga-DOTATATE Biodistribution in a Case With Neuroendocrine Tumor. [Case Reports]
    Clin Nucl Med. 2023 Feb 01; 48(2):e71-e73.Tatar G, Beyhan E, … Çermik TF
  • A 58-year-old man who underwent surgery for a well-differentiated neuroendocrine tumor of pancreatic origin was evaluated with 68Ga-DOTATATE PET/CT imaging in the follow-up period. After PET/CT findings consistent with disease remission, the patient was started on leflunomide treatment with the diagnosis of rheumatoid arthritis. The patient received leflunomide for 6 months. Then, 68Ga-DOTATATE P…
  • Vascular neoplasia masquerading as cellulitis and persistent hemorrhagic pericardial effusion. [Case Reports]
    Ann Pediatr Cardiol. 2022 May-Jun; 15(3):304-307.Thangaraju S, Relan J, … Raju SN
  • Tufted angioma and kaposiform hemangioendothelioma are considered to represent two ends of the spectrum of benign vascular neoplasms that predominantly present during infancy or early childhood. We report a rare case of a 5-month-old infant with complicated vascular neoplasm involving the pericardial cavity and skin over cervical region, masquerading as infective pericarditis with cellulitis. The…
  • Diphtheritic myocarditis: An unusual and reversible cause of heart failure. [Case Reports]
    Ann Pediatr Cardiol. 2022 May-Jun; 15(3):311-313.Arvind B, Ojha V, … Ramakrishnan S
  • Diphtheria is a life-threatening infectious disease caused by Corynebacterium diphtheriae. Although the disease is seen infrequently in the postvaccination era, sporadic cases continue to occur. Cardiac involvement, in the form of myocarditis, is the most serious manifestation of diphtheria and is the most common cause of mortality in these patients. The features of diphtheritic myocarditis on ca…
  • Cutaneous Nrf2-Keap1 pathway modulation by environmental factors: The Dead Sea area as a test case. [Journal Article]
    Biofactors. 2022 Dec 15 [Online ahead of print]Cohen D, Portugal-Cohen M, … Kohen R
  • The skin is constantly exposed to exogenous environmental stressors and has to cope with excessive oxidative stress and tissue damage. However, exposure to moderate environmental stressors may be beneficial for the cutaneous tissue and assist in protecting against oxidative damage via the enhanced activation of the nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (N…
  • Hypomagnesaemia - One Cause To Remember! [Journal Article]
    Eur J Case Rep Intern Med. 2022; 9(11):003637.Viegas AF, Lopes AFM, … Tavares JP
  • CONCLUSIONS: PPIs-related hypomagnesaemia should be a concern, especially in cases with refractory hypomagnesaemia and after excluding other common causes.Formal indication for PPIs use should be revised in most patients.
  • Reactive Arthritis Triggered by Adalimumab and Leflunomide in a Patient with Ankylosing Spondylitis. [Case Reports]
    Clin Cosmet Investig Dermatol. 2022; 15:2601-2605.Liu Y, He J, … Liu T
  • Reactive arthritis (ReA) is uncommon. The present case is a Chinese man who has been treated with adalimumab and leflunomide to control ankylosing spondylitis (AS). During the treatment, the patient developed a range of symptoms, including fever, fatigue, pustular rash, suppurative urethritis, genital ulcers, oral ulcers, bilateral uveitis, heel pain and swelling and pain of the knee and ankle jo…
  • Unveiling the membrane bound dihydroorotate: Quinone oxidoreductase from Staphylococcus aureus. [Journal Article]
    Biochim Biophys Acta Bioenerg. 2022 Dec 06; 1864(2):148948.Sousa FM, Pires P, … Pereira MM
  • Staphylococcus aureus is an opportunistic pathogen and one of the most frequent causes for community acquired and nosocomial bacterial infections. Even so, its energy metabolism is still under explored and its respiratory enzymes have been vastly overlooked. In this work, we unveil the dihydroorotate:quinone oxidoreductase (DHOQO) from S. aureus, the first example of a DHOQO from a Gram-positive …
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