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Unbound Medicine.
(Arctium lappa)
474 results
  • The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review. [Review]
    Phytomedicine. 2023 Feb; 110:154647.Wang G, Ge L, … Chen L
  • CONCLUSIONS: Inhibition of PI3K/AKT pathway and activation of AMPK signaling play the pivotal roles in the therapeutic effects of ATG. PI3K/AKT and AMPK signaling widely link to other signaling pathways, modulating various biological processes such as anti-inflammation, anti-oxidative stress, anti-fibrosis, anti-ER stress, anti-steatosis and pro-apoptosis, which constitute the curative mechanisms of ATG against multiple human diseases.
  • Phytochemicals and Biological Activities of Burdock (Arctium lappa L.) Extracts: A Review. [Review]
    Chem Biodivers. 2022 Nov; 19(11):e202200615.de Souza ARC, de Oliveira TL, … Bavia L
  • Arctium lappa L., also known as burdock, is an edible wild plant which has the ability to grow in distinct environments and is considered a weed in several parts of the world. This species has great value in the biological and medical fields with its major secondary components being phenolic compounds and terpenes, substances rich in desired biological activities as antioxidant, antimicrobial, an…
  • Arctigenin: pharmacology, total synthesis, and progress in structure modification. [Journal Article]
    J Enzyme Inhib Med Chem. 2022 Dec; 37(1):2452-2477.Wu D, Jin L, … Guo HY
  • Arctium lappa L. is a prevalent medicinal herb and a health supplement that is commonly used in Asia. Over the last few decades, the bioactive component arctigenin has attracted the attention of researchers because of its anti-inflammatory, antioxidant, immunomodulatory, multiple sclerosis fighting, antitumor, and anti-leukemia properties. After summarising the research and literature on arctigen…
  • Chlorogenic acid: A dietary phenolic acid with promising pharmacotherapeutic potential. [Journal Article]
    Curr Med Chem. 2022 Aug 16 [Online ahead of print]Singh AK, Singla RK, Pandey AK
  • Phenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid that is being utilized in traditional medicine is chlorogenic acid (CGA). It is one of the most readily available phytochemicals that can be isolated from the leaves and fruits of plants such a…
  • Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus. [Review]
    Food Sci Biotechnol. 2022 Jul; 31(8):999-1008.Mondal SC, Eun JB
  • Diabetes mellitus (DM) type 2 is amongst the most common chronic diseases, being responsible for various problems in humans and contributing to increased mortality rates worldwide. Fructooligosaccharide, which can be produced from the roots of burdock (Arctium lappa L.), has been shown to have a wide range of pharmacological proprieties, including antiviral, anti-inflammatory, hypolipidemic, and …
  • Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves. [Review]
    Bioorg Chem. 2022 10; 127:105940.Liang H, Feng Q, … Dai L
  • Nine new cadinane-type sesquiterpenoids (1-9) and three new eucalyptane -type sesquiterpenes (10-12) were isolated from the ethyl acetate extract of Burdock leaves, which were commonly used for preventing or treating atherosclerosis in China. Their structures were confirmed by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis and ECD calculations. Compound 1 possessed th…
  • Exotic Medicinal Plants Used in Brazil with Diuretic Properties: A Review. [Review]
    Chem Biodivers. 2022 Jun; 19(6):e202200258.Mariano LNB, Boeing T, … de Souza P
  • Several exotic plants (non-native) are used in Brazilian traditional medicine and are known worldwide for their possible diuretic actions. Among the wide variety of plants, standing out Achillea millefolium L., Camellia sinensis L. Kuntze, Crocus sativus L., Hibiscus sabdariffa Linn., Petroselinum crispum (Mill.) A.W. Hill, Taraxacum officinale (L.) Weber, and Urtica dioica L., whose effects have…
  • Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1. [Journal Article]
    Bioengineered. 2022 04; 13(4):10866-10874.Liu Z, Wu Y
  • Osteoporosis is a systemic disorder of bone metabolism. This study aimed to investigate the impacts and possible mechanisms of Arctiin, a lignin isolated from Arctium lappa on MC3T3-E1 osteoblast differentiation. In this study, after treatment with different concentrations of Arctiin, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were used to estimate…
  • Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. [Journal Article]
    Eur J Case Rep Intern Med. 2022; 9(3):003247.Latif A, Fichadiya H, … Capo G
  • CONCLUSIONS: Over-the-counter herbal products marketed as having beneficial effects are not always harmless and can have clinically significant side effects.When investigating the causes of thrombocytopenia, physicians should be aware of and search for this rare cause.Treatment for herbal tea-induced thrombocytopenia is the same as for immune thrombocytopenia (i.e., steroids and platelet transfusion if there is actively bleeding).
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