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288 results
  • Bitter Taste Receptors as Regulators of Abdominal Muscles Contraction. [Journal Article]
    Physiol Res. 2019 12 30; 68(6):991-995.Zagorchev P, Petkov GV, Gagov HS
  • Bitter taste receptors (TAS2R) are expressed in many non-sensor tissues including skeletal muscles but their function remains unexplored. The aim of this study is to investigate the role of TAS2R in rat abdominal skeletal muscles contractions using denatonium, a TAS2R agonist. Low concentration of denatonium (0.01 mmol/l) caused a significant decrease of amplitudes of the electrical field stimula…
  • Design and evaluation of artificial receptors for the reversal of neuromuscular block. [Journal Article]
    Int J Pharm. 2017 Oct 15; 531(2):512-520.Sohajda T, Fábián Á, … Szente L
  • Applying patient friendly and cost-efficient medications in healthcare will be a real challenge in the 21st century. Sugammadex is a selective, yet expensive agent used for the post-surgical reversal of neuromuscular block since 2008. A wide library of cyclodextrin-based follow-ups, having potentially similar affinity towards target aminosteroid type neuromuscular blocking agents has been establi…
  • A novel experimental model of acute respiratory distress syndrome in pig. [Journal Article]
    Physiol Res. 2016 12 22; 65(Suppl 5):S643-S651.Otáhal M, Mlček M, … Kittnar O
  • Acute respiratory distress syndrome (ARDS) is severe medical condition occurring in critically ill patients and with mortality of 33-52 % is one of the leading causes of death in critically ill patients. To better understand pathophysiology of ARDS and to verify novel therapeutical approaches a reliable animal model is needed. Therefore we have developed modified lavage model of ARDS in the pig. …
  • Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes. [Review]
    Cytokine Growth Factor Rev. 2016 Apr; 28:71-7.Donate-Correa J, Martín-Núñez E, … Navarro González JF
  • Diabetes mellitus, especially type 2 diabetes, remains the dominant metabolic disease worldwide, with an expected increase in prevalence of over 50% in the next 20 years. Our knowledge about the pathophysiology of type 2 diabetes continues to be incomplete, with unmet medical need for new therapies. The characterization of the fibroblast growth factor (FGF) family and the discovery of endocrine F…
  • Bisphenol a in chronic kidney disease. [Journal Article]
    Int J Nephrol. 2013; 2013:437857.González-Parra E, Herrero JA, … Egido J
  • Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some dialyzers. BPA is considered an environmenta…
  • [Evaluation of muscle relaxant requirement for hospital anesthesia]. [Journal Article]
    Voen Med Zh. 2013 Mar; 334(3):20-6.Shchegolev AV, Levshankov AI, … Dumnov AG
  • The rationale for cost-effectiveness of modern muscle relaxants (MR) administration in general anesthesia was evaluated. New MRs are more expensive than traditionally used pipecuronium and succinylcholine. However, the old MRs are often required as a block reversion with anticholinesterase medicines at the end of surgery, the longer artificial lung ventilation and observation in patients during r…
  • [Ketamine versus propofol during one-lung ventilation in thoracic surgery]. [Clinical Trial]
    Anesteziol Reanimatol. 2012 May-JunVyzhigina OA, Kurilova OA, … Parshin VD
  • A comparative analysis of gas, the metabolic rate, pressor, resistive and volumetric characteristics of pulmonary blood flow, central and intracardiac hemodynamics in patients undergoing thoracic surgery was conducted. 2 methods of anesthesia maintenance: on the basis of ketamine - fentanyl - pipecuronium and propofol - fentanyl - pipecuronim were compared. Invasive monitoring system PiCCOplus fo…
  • Effect of magnesium sulphate on urinary catecholamine excretion in severe tetanus. [Randomized Controlled Trial]
    Anaesthesia. 2008 Jul; 63(7):719-25.Thwaites CL, Yen LM, … Farrar JJ
  • Severe tetanus is characterised by muscle spasms and autonomic dysfunction. We recently reported the results of a randomised placebo controlled trial of magnesium sulphate infusions for the treatment of severe tetanus which showed magnesium was associated with improved muscle spasm and cardiovascular control. We hypothesised that magnesium controlled autonomic dysfunction by reducing catecholamin…
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