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10,083 results
  • Black thyroid gland and tracheal cartilage. [Case Reports]
    BMJ Case Rep. 2023 Jan 20; 16(1)Lam A, Kaufmann B, Cunningham K
  • A woman in her 70s with a history of chronic minocycline use presented with complaints of a non-tender posterior neck mass. A thyroid gland ultrasound showed a highly suspicious right thyroid nodule. A total thyroidectomy revealed darkened discolouration of the thyroid gland and tracheal cartilage. The pathology report showed dark brown granules representing melanin. Chronic minocycline usage is …
  • Anti-Inflammatory Treatment Efficacy in Major Depressive Disorder: A Systematic Review of Meta-Analyses. [Review]
    Neuropsychiatr Dis Treat. 2023; 19:1-25.Simon MS, Arteaga-Henríquez G, … Illigens BMW
  • CONCLUSIONS: Even in our synthesized approach, no clear recommendations could be derived on the use of anti-inflammatory treatment for MDD due to several critical aspects like heterogeneity, diversity of patient populations, treatment regimen, and outcomes, and limited scientific quality. However, we observed clear inter-substance differences with meta-analytic evidence being strongest for celecoxib and weakest for omega 3 fatty acids.
  • The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter. [Journal Article]
    Sci Total Environ. 2023 Jan 05; 867:161416.Li B, Chang X, … Zheng J
  • Epidemiological studies have shown that ambient fine particulate matter (PM) can cause various neurodegenerative diseases, including Alzheimer's disease. Reactive astrocytes are strongly induced by ambient fine PM, although their role is poorly understood. Herein, we show that A1 reactive astrocytes (A1s) were induced by neuroinflammatory microglia activated by PM with an aerodynamic diameter ≤ 0…
  • Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. [Journal Article]
    Mol Neurobiol. 2023 Jan 05 [Online ahead of print]Yang F, Jing JJ, … Zou YQ
  • Central post-stroke pain (CPSP) is a highly refractory form of central neuropathic pain that has been poorly studied mechanistically. Recent observations have emphasized the critical role of the spinal dorsal horn in CPSP. However, the underlying mechanisms remain unclear. In this study, rats were subjected to thalamic hemorrhage to investigate the role of spinal monocyte chemoattractant protein-…
  • Exploration of treatments for subarachnoid hemorrhage. [Journal Article]
    J Biomed Res (Middlet). 2022; 3(1):48-55.Hosseini Siyanaki MR, Lucke-Wold B, Khan M
  • Subarachnoid hemorrhage (SAH) continues to be a leading cause of morbidity and mortality, with cerebral vasospasm as a common etiology of worse clinical progression. The purpose of this study was to evaluate and review the current literature concerning the effective treatment of SAH. The treatment options for SAH are expanding as new therapeutic targets are identified. Nimodipine is the primary m…
  • Sex Dimorphism in Resolvin D5-induced Analgesia in Rat Models of Trigeminal Pain. [Journal Article]
    J Pain. 2022 Dec 28 [Online ahead of print]Baggio DF, da Luz FMR, … Chichorro JG
  • Resolvin D5 (RvD5) is a specialized pro-resolving lipid mediator with potent anti-inflammatory and analgesic properties. Orofacial pain conditions, especially those that are chronic, present clinical challenges in terms of pharmacological management. Thus, new therapeutic options are clearly warranted. Herein, we investigated the antinociceptive effect of RvD5 in the chronic constriction injury o…
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