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246 results
  • The role of the paravertebral ganglia in human sympathetic neural discharge patterns. [Journal Article]
  • JPJ Physiol 2018; 596(18):4497-4510
  • Klassen SA, Limberg JK, … Shoemaker JK
  • CONCLUSIONS: The mechanisms affecting recruitment patterns of postganglionic sympathetic nerves remain unclear. The divergent and convergent preganglionic innervation patterns of postganglionic neurons and the presence of differently sized postganglionic nerves suggest that the ganglia may participate in modifying the discharge patterns of single sympathetic postganglionic neurons innervating the skeletal muscle circulation. Whether the ganglia affect the ordered behaviour of varying sized postganglionic sympathetic neurons in humans has not been studied. Trimethaphan infusion produced an ordered pattern of action potential (AP) de-recruitment whereby the firing of larger, low probability APs present at baseline was abolished first, followed by progressive decreased probability of smaller APs. Although integrated sympathetic bursts were no longer detected after several minutes of trimethaphan, firing of the smallest APs was detected. These data suggest the ganglia affect the distribution of firing probabilities exhibited by differently sized sympathetic neurons. The ganglia may contribute to sympathetic neural emission patterns involved in homeostatic regulation.
  • Comparison of different cardiac relaxation indices. [Journal Article]
  • BEBull Exp Biol Med 2001; 131(5):416-20
  • Alipov NN, Izrail'tyan IM, … Kuznetsova TE
  • Sensitivity (response to epinephrine infusion) and specificity (response to changes in pre- and afterload) of some cardiac relaxation indices were compared in acute experiments on cats treated with g...
  • The diagnosis and management of hypertensive crises. [Review]
  • ChestChest 2000; 118(1):214-27
  • Varon J, Marik PE
  • Severe hypertension is a common clinical problem in the United States, encountered in various clinical settings. Although various terms have been applied to severe hypertension, such as hypertensive ...
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