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1,649 results
  • Long VITT: A case report. [Letter]
    Thromb Res. 2023 Jan 24; 223:78-79.Roberge G, Carrier M
  • Vaccine-induced immune thrombotic thrombocytopenia (VITT) has been described following adenovirus vector-based COVID-19 vaccines. This condition is associated with important morbidity and mortality following thrombosis related complications. Diagnosis is confirmed based on results of platelet factor 4 ELISA detecting anti-PF4 antibodies and of platelet-activation assay. Initial treatment strategy…
  • Highlights in TMPRSS2 inhibition mechanism with guanidine derivatives approved drugs for COVID-19 treatment. [Journal Article]
    J Biomol Struct Dyn. 2023 Jan 29 [Online ahead of print]Tachoua W, Kabrine M, … Ul-Haq Z
  • Transmembrane protease serine 2 (TMPRSS2) has been identified as a critical key for the entry of coronaviruses into human cells by cleaving and activating the spike protein of SARS-CoV-2. To block the TMPRSS2 function, 18 approved drugs, containing the guanidine group were tested against TMPRSS2's ectodomain (7MEQ). Among these drugs, Famotidine, Argatroban, Guanadrel and Guanethidine strongly bi…
  • Long-term Anticoagulation with Apixaban in Patients with Cerebral Venous Thrombosis. [Journal Article]
    Clin Appl Thromb Hemost. 2023 Jan-Dec; 29:10760296221129591.Bharath SP, Arshad H, … Kirmani JF
  • Introduction: Cerebral venous thrombosis (CVT) is a life-threatening neurological condition. There is limited evidence for the use of direct oral anticoagulants (DOAC) for long-term anticoagulation in this patient population. We report a case series of patients treated with apixaban and their clinical course. Methods: This was a retrospective cohort study. Patients diagnosed with CVT in a defined…
  • Cardiopulmonary Bypass Surgery in a Patient with Unexpected Heparin-Induced Thrombocytopenia. [Journal Article]
    Ann Vasc Dis. 2022 Dec 25; 15(4):352-355.Miyagawa A, Yuri K, … Makino J
  • We report a case of a 77-year-old woman with massive pulmonary embolism associated with heparin-induced thrombocytopenia. Before developing a pulmonary embolism, the patient underwent gastrectomy due to gastric cancer and received subcutaneous heparin calcium for deep venous thrombosis prophylaxis for 5 d. Then, thrombectomy with cardiopulmonary bypass using full heparinization was successfully p…
  • Anticoagulation Management during Extracorporeal Membrane Oxygenation-A Mini-Review. [Review]
    Medicina (Kaunas). 2022 Dec 03; 58(12)Burša F, Sklienka P, … Máca J
  • Extracorporeal membrane oxygenation (ECMO) has been established as a life-saving technique for patients with the most severe forms of respiratory or cardiac failure. It can, however, be associated with severe complications. Anticoagulation therapy is required to prevent ECMO circuit thrombosis. It is, however, associated with an increased risk of hemocoagulation disorders. Thus, safe anticoagulat…
  • Targeting MRG15 for the treatment of nonalcoholic steatohepatitis. [Editorial]
    Metabol Open. 2022 Dec; 16:100217.Zhang Y, Dalamaga M, Liu J
  • Non-alcoholic fatty liver disease represents the most common liver disease worldwide and the prevailing cause of liver-related morbidity and mortality. It encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma. There have been many studies about the underlying mechanisms…
  • A Case Report and Literature Review on Argatroban Refractory Heparin-Induced Thrombocytopenia. [Case Reports]
    J Community Hosp Intern Med Perspect. 2022; 12(5):102-105.Deen IU, Jha SA, Mustafa S
  • Heparin-induced thrombocytopenia (HIT) is characterized by low platelets and thrombosis after exposure to Heparin products. It is classically characterized by a rapid and significant drop in platelets and life-threatening thrombosis. Thrombosis can occur up to 50% of the cases if left untreated. It requires immediate discontinuation of all heparin products and switching to a non-heparin anticoagu…
  • StatPearls: Argatroban [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)MahatKrishna C.KCSindhupalchok District HospitalSedhaiYub RajYRVirginia Commonwealth Un School of MedKrishnanPrathikPSUNY Upstate Medical UniversityBOOK
  • Argatroban is a medication used in the management of heparin-induced thrombocytopenia (HIT), which is a rare, life-threatening complication of heparin therapy. It is a direct thrombin inhibitor, a class of anticoagulant drugs. This activity outlines the indications, action, and contraindications for argatroban as a valuable agent in the prophylaxis and treatment of thrombosis in patients with HI…
  • A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia. [Case Reports]
    Cureus. 2022 Jul; 14(7):e27204.Harrison H, Rezaei H, Dalal N
  • This report discusses a case of a 37-year-old female who developed vaccine-induced thrombotic thrombocytopenia (VITT) after receiving the Johnson and Johnson COVID-19 vaccination. The patient first presented to the ED with complaints of a worsening headache. Labs were significant for thrombocytopenia with a platelet count of 22,000, and the patient was admitted to the inpatient unit for monitorin…
  • Effects of wasp venom on venous thrombosis in rats. [Journal Article]
    Iran J Basic Med Sci. 2022 Jul; 25(7):822-826.Jin FM, Wang M, … Zhao HR
  • CONCLUSIONS: We improved the model of IVC thrombosis to be suitable for evaluation of antithrombotic drugs. Our findings demonstrated that WV could inhibit IVC thrombosis associated with reducing coagulation factors V and CD61+CD62p expression in rats.
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