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2,186 results
  • Design of an Ultralow Molecular Weight Heparin That Resists Heparanase Biodegradation. [Journal Article]
    J Med Chem. 2023 Jan 27 [Online ahead of print]Ham H, Xu Y, … Chaikof EL
  • Heparanase, an endo-β-d-glucuronidase produced by a variety of cells and tissues, cleaves the glycosidic linkage between glucuronic acid (GlcA) and a 3-O- or 6-O-sulfated glucosamine, typified by the disaccharide -[GlcA-GlcNS3S6S]-, which is found within the antithrombin-binding domain of heparan sulfate or heparin. As such, all current forms of heparin are susceptible to degradation by heparanas…
  • Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. [Journal Article]
    J Thromb Haemost. 2022 Dec 22 [Online ahead of print]Cai Z, Bdeir K, … Cines DB
  • CONCLUSIONS: HIT antigen and immune complexes are dynamic and amenable to modulation. Fondaparinux can be converted from an anticoagulant that acts at a downstream amplification step into a rationale, disease-specific intervention that blocks ULIC formation. Interventions that prevent ULIC formation and stability might increase the efficacy, permit use of lower doses, shorten the duration of antithrombotic therapy, and help prevent this serious thrombotic disorder.
  • Fondaparinux Sodium: Recent Advances in the Management of Thrombosis. [Review]
    J Cardiovasc Pharmacol Ther. 2023 Jan-Dec; 28:10742484221145010.Bauersachs RM
  • Fondaparinux sodium is a chemically synthesized selective factor Xa inhibitor approved for the prevention and treatment of venous thromboembolic events, that is, deep vein thrombosis, pulmonary embolism, and superficial vein thrombosis, in acutely ill (including those affected by COVID-19 or cancer patients) and those undergoing surgeries. Since its approval in 2002, the efficacy and safety of fo…
  • Design and Synthesis of Neutralizable Fondaparinux. [Journal Article]
    JACS Au. 2022 Dec 26; 2(12):2791-2799.Zhang L, Liu Y, … Li T
  • Fondaparinux, a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs. However, there is no suitable antidote available for fondaparinux to efficiently manage its potential bleeding risks, thereby precluding its widespread use. Herein, we describe a convergent and stereocontro…
  • Potential Application of Recombinant Snake Prothrombin Activator Ecarin in Blood Diagnostics. [Journal Article]
    Biomolecules. 2022 11 17; 12(11)Zhao KN, Masci P, … Lavin MF
  • We describe here the purification and cloning of a codon-optimized form of the snake prothrombin activator ecarin from the saw scaled viper (Echis carinatus) expressed in mammalian cells. Expression of recombinant ecarin (rEcarin) was carried out in human embryonic kidney cells (HEK) cells under conditions for the development and performance of a novel and scalable recombinant snake ecarin to ind…
  • Facile chemoenzymatic synthesis of unmodified anticoagulant ultra-low molecular weight heparin. [Journal Article]
    Org Biomol Chem. 2022 Nov 02; 20(42):8323-8330.Zhang G, Yang K, … Liu C
  • A chemoenzymatic approach, mimicking the biosynthetic pathway of heparin and heparan sulfate (HS), has been well developed to prepare a series of structurally well-defined heparin oligosaccharides with excellent anticoagulant activity in good overall yields. The current chemoenzymatic synthesis typically begins with an unnatural glycosyl acceptor, p-nitrophenyl glucuronide (GlcA-PNP), which is co…
  • Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. [Journal Article]
    J Med Virol. 2023 Jan; 95(1):e28124.Wettstein L, Immenschuh P, … Münch J
  • Host cell proteases such as TMPRSS2 are critical determinants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism and pathogenesis. Here, we show that antithrombin (AT), an endogenous serine protease inhibitor regulating coagulation, is a broad-spectrum inhibitor of coronavirus infection. Molecular docking and enzyme activity assays demonstrate that AT binds and inhibits TMPRS…
  • Treatment modalities in cancer-associated venous thromboembolism (VTE). [Review]
    Best Pract Res Clin Haematol. 2022 03; 35(1):101354.Soto Alsar J, Gutiérrez Ortiz de la Tabla A, … Muñoz Martín AJ
  • Anticoagulation is the cornerstone of cancer-associated VTE treatment, including vitamin K antagonists (VKA), unfractionated heparin (UFH), fondaparinux, low-molecular-weight heparins (LMWH) and direct oral anticoagulants (DOACs). The goals of anticoagulant therapy in cancer patients with cancer-associated thrombosis (CAT) are to improve symptoms, reduce risk of recurrent VTE or fatal pulmonary e…
  • Deep vein thrombosis after insertion of a central venous catheter: a case report. [Case Reports]
    Pan Afr Med J. 2022; 42:25.Mukti I, Tjempakasari A
  • A male patient aged 50 years, presented with a swelling in the right leg which had occurred five days before hospital admission. This was associated with pain in the swollen leg. The patient had a history of femoral double lumen catheter (DLC) insertion for hemodialysis. On physical examination, Wong Baker's scale was 3, Wells' score was 3, and the patient had edematous, red, and warm right lower…
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