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(Armed Forces Radiobiological Research Institute)
9 results
  • Significant disparity in base and sugar damage in DNA resulting from neutron and electron irradiation. [Journal Article]
    J Radiat Res 2014; 55(6):1081-8Pang D, Nico JS, … Jaruga P
  • In this study, a comparison of the effects of neutron and electron irradiation of aqueous DNA solutions was investigated to characterize potential neutron signatures in DNA damage induction. Ionizing radiation generates numerous lesions in DNA, including base and sugar lesions, lesions involving base-sugar combinations (e.g. 8,5'-cyclopurine-2'-deoxynucleosides) and DNA-protein cross-links, as we…
  • Nuclear, biological, and chemical combined injuries and countermeasures on the battlefield. [Journal Article]
    Mil Med 2002; 167(2 Suppl):95-7Knudson GB, Elliott TB, … Ledney GD
  • The Armed Forces Radiobiological Research Institute (AFRRI) has developed a research program to determine the major health risks from exposure to ionizing radiation in combination with biological and chemical warfare agents and to assess the extent to which exposure to ionizing radiation compromises the effectiveness of protective drugs, vaccines, and other biological and chemical warfare prophyl…
  • Radon-induced cancer: a cell-based model of tumorigenesis due to protracted exposures. [Review]
    Int J Radiat Biol 1994; 66(5):649-53Elkind MM
  • In 1982, results with C3H mouse embryo cells showed that the frequency of neoplastic transformation was enhanced when exposures to fission-spectrum neutrons were protracted in time. This finding was unexpected because the opposite was found with low-LET radiations. Similar neutron enhancements were reported with normal life-span Syrian hamster embryo cells, and with human hybrid cells. Because ot…
  • Nonuniform irradiation of the canine intestine. II. Dosimetry. [Journal Article]
    Radiat Res 1990; 121(1):54-62Zeman GH, Mohaupt TH, … Vigneulle RM
  • An experimental model has been developed for quantitative studies of radiobiological damage to the canine small intestine following partial-body nonuniform irradiation. Animals were irradiated with 60Co gamma rays to simulate the nonuniform irradiation which do occur in victims of radiation accidents. The model used a short source-to-surface distance for unilateral irradiations to produce a dose …
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