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3,586 results
  • Pediatric primary extra-ovarian Sertoli Leydig cell tumor of the retroperitoneum. [Journal Article]
    Indian J Pathol Microbiol. 2023 Jan-Mar; 66(1):145-147.Panigrahi C, Mishra P, … Sable M
  • Ovarian Sertoli Leydig cell tumors (SLCT) accounts for less than 0.5% of all ovarian malignancies. The incidence of primary extra-ovarian SLCT is extremely rare with reported cases occurring in young adult women till now. We report case of primary retroperitoneal extra-ovarian SLCT in a seven-year girl child without any hormonal manifestation. She presented with complaint of left side abdominal s…
  • Key changes in WHO classification 2022 of testicular tumors. [Journal Article]
    Cesk Patol. 2022 Fall; 67(4):198-204.Michalová K, Hes O, Michal M
  • Compared to the WHO classification of the male genital tumors in 2016, minimal changes were introduced in the current WHO 2022. Classification of germ cell tumors remains the same as in the previous edition, dividing germ cell tumors into those derived from germ cell neoplasia in situ (GCNIS) and those independent of GCNIS. The group of GCNIS derived germ cell tumors is essentially unchanged. Mos…
  • Histidine decarboxylase inhibitors: a novel therapeutic option for the treatment of leydigioma. [Journal Article]
    J Endocrinol. 2022 12 01; 255(3):103-116.Abiuso AMB, Varela ML, … Mondillo C
  • Recent reports indicate an increase in Leydig cell tumor (LCT) incidence. Radical orchiectomy is the standard therapy in children and adults, although it entails physical and psychosocial side effects. Testis-sparing surgery can be a consideration for benign LCT of 2.5 cm or less in size. Malignant LCTs respond poorly to conventional chemotherapy, so new treatment modalities are needed. In this s…
  • DICER1-Altered Extraovarian Moderately Differentiated Sertoli-Leydig Cell Tumor: Report of a Rare Case. [Journal Article]
    Int J Gynecol Pathol. 2022 Aug 03 [Online ahead of print]Lau JCC, McCluggage WG, … Liu APY
  • We report an unusual case of a pelvic extraovarian moderately differentiated Sertoli-Leydig cell tumor arising in a 4-yr-old female. The tumor contained a DICER1 pathogenic variant which was absent in the germline ruling out DICER1 syndrome. In reporting this case, we discuss the differential diagnosis and possible histogenesis and review reported cases of extraovarian Sertoli-Leydig cell tumor.
  • Sertoli-Leydig cell ovarian tumour: a rare cause of virilisation and androgenic alopecia. [Case Reports]
    BMJ Case Rep. 2022 Aug 25; 15(8)Mudraje S, Shetty S, … Kudva R
  • Sertoli-Leydig cell tumours (SLCTs) represent a rare cause of hyperandrogenic state. SLCTs are sex cord ovarian neoplasms, accounting for <0.2% of all ovarian tumours. Most of the sex cord-stromal tumours have a benign clinical course, with 10%-20% of them at risk of aggressive course. We report a case of a woman in her 30s who presented with androgenic alopecia, virilisation and secondary amenor…
  • Complete androgen insensitivity syndrome - rare case of malignancy of dysgenetic gonads. [Case Reports]
    Ceska Gynekol. 2022; 87(3):184-187.Gamcová Viktória, Eim Josef, … Hudeček Robert
  • CONCLUSIONS: Complete androgen insensitivity syndrome is a rare genetic disease characterized by varying degrees of feminization in individuals with a male karyotype. It should not be neglected, especially in the differential diagnostic work-up of primary amenorrhea. Genetic testing of the karyotype should be performed whenever uterine agenesis is suspected.
  • Hyperandrogenism due to ovarian Leydig cell tumour presenting with polycythaemia. [Case Reports]
    BMJ Case Rep. 2022 Jul 15; 15(7)Demir AY, Blok BB, … Oldenburg-Ligtenberg CP
  • A postmenopausal woman in her 60s was referred due to an elevated haemoglobin value found during her annual check-up. On physical examination, characteristic features of hyperandrogenism were observed which were not earlier mentioned. Laboratory investigations revealed polycythaemia accompanied by a normal erythropoietin and a negative analysis for JAK2-V617F mutation. A disproportionally and mar…
  • Sex cord stromal tumors and tumors of the paratestis: new and old entities in a landscape of rare tumors. [Review]
    Curr Opin Urol. 2022 07 01; 32(4):339-343.Colecchia M, Raspollini MR, … Pini GM
  • The 5th edition of WHO classification incorporates the most relevant new data available in the literature regarding tumors of the male genitourinary tract. In this review, the authors summarize and critically discuss the most relevant new information regarding tumors occurring in the stromal testis and in the paratestis that will be reported in the new edition of WHO classification of tumors of t…
  • Spontaneous neoplasms in harbour porpoises Phocoena phocoena. [Journal Article]
    Dis Aquat Organ. 2022 Jun 23; 149:145-154.Gregor KM, Lakemeyer J, … Wohlsein P
  • Harbour porpoises are widely distributed in the North Atlantic and represent the most abundant cetacean species in the North and Baltic Seas. Spontaneous neoplasms are relatively rarely reported in cetaceans, and only little is known about neoplasia in harbour porpoises. Thus, archival material was reviewed for spontaneous neoplasms in harbour porpoises recorded during post-mortem examinations be…
  • Update on Ovarian Sex Cord-Stromal Tumors. [Review]
    Surg Pathol Clin. 2022 Jun; 15(2):235-258.Ordulu Z
  • This article focuses on the recent advances in ovarian sex cord-stromal tumors, predominantly in the setting of their molecular underpinnings. The integration of genetic information with morphologic and immunohistochemical findings in this rare subset of tumors is of clinical significance from refining the diagnostic and prognostic stratifications to genetic counseling.
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