- Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats. [Journal Article]
- CONCLUSIONS: Our data indicated that SSO protected the liver, colon and bone marrow potentially via anti-inflammatory and anti-apoptotic activities. The data suggest that sesame oil has potential therapeutic applications against chemical toxicities induced by arsenic.
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- Ameliorative effect of Brassica oleracea var. Italica extract on oxidative damage of arsenic in the rat's brain: biochemical, pathological, and behavioral aspects. [Journal Article]Metab Brain Dis. 2023 Jan 26 [Online ahead of print]MB
- Brain damage caused by the metal accumulation may result in the permanent injuries including severe neurological disorders. Thus, the aim of this study was to determine the medicinal efficacy of broccoli extract in arsenic-induced brain poisoning. Twenty-eight female rats were classified into 4 groups; control, receiving sodium arsenate (As), As + broccoli extract (As + Bc), and (Bc). Then, the E…
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- Glutathione Might Attenuate Arsenic-Induced Liver Injury by Modulating the Foxa2-XIAP Axis to Reduce Oxidative Stress and Mitochondrial Apoptosis. [Journal Article]Biol Trace Elem Res. 2023 Jan 23 [Online ahead of print]BT
- Arsenic (AS) is a metalloid element that widely exists and can cause different degrees of liver damage. The molecular mechanism of arsenic-induced liver injury has yet to be fully elucidated. Clinically, glutathione (GSH) is often used as an antidote for heavy metal poisoning and hepatoprotective drugs. However, the hepatoprotective effect of glutathione remains unknown in arsenic-induced liver i…
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- Changes in Arsenic Speciation in Wild Edible Fungi after Different Cooking Processes and Gastrointestinal Digestion. [Journal Article]
- Arsenic (As) is enriched in wild edible fungi, which is one of the main important sources of As in humans' diet. In this study, two wild edible fungi were employed for investigation: (1) Pleurotus citrinopileatusone, which contains a high content of inorganic As (iAs) and (2) Agaricus blazei Murill, which contains a high content of organic As. This study investigated the changes in As content and…
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- Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations. [Journal Article]
- Inorganic arsenic is highly toxic and carcinogenic to humans. Exposed individuals vary in their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is associated with risks of arsenic-related toxicities. Inherited genetic variation in the 10q24.32 region, near the arsenic methyltransferase (AS3MT) gene, is associated with urine-based measures of AME in multiple a…
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- "The Terror of Death Began To Stalk Him": The Mysterious Fistula of Charles the Wise. [Review]
- For 23 years, Charles V "The Wise" of France suffered from a mysterious fistula on his left arm that continuously drained pus. For all this time, he believed that as soon as the fistula ceased to weep, he would have a mere 15 days before death followed. His death in 1380, at the young age of 42, seemingly proved this assumption correct. This paper explores the possible explanations from arsenic p…
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- [Determination of six arsenic species in urine by high-performance liquid chromatography-inductively coupled plasma-mass spectrometr]. [Journal Article]Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Dec 20; 40(12):952-955.ZL
- Objective: Establishing an analysis method for the detection of six arsenic compounds trivalent arsenic, pentavalent arsenic, methyl arsenic, dimethyl arsenic, arsenical choline and arsenical betaine in urine by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) and providing a theoretical basis for health assessment of arsenic poisoning patients. Me…
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- Investigation and monitoring of heavy metal poisoning. [Review]J Clin Pathol. 2023 Feb; 76(2):82-97.JC
- Historically, heavy metal measurement and interpretation has been a highly specialised area performed only in a handful of centres within the UK. However, recent years have seen a move to more local testing due to the repatriation of referred work into pathology networks and the increased availability of inductively coupled plasma mass spectrometry technology. While management of significant pois…
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- Lead, cadmium, and other trace elements in the liver of golden eagles and white-tailed eagles: recent data from Poland and a systematic review of previous studies. [Journal Article]Environ Sci Pollut Res Int. 2022 Dec 30 [Online ahead of print]ES
- The golden eagle (Aquila chrysaetos) and the white-tailed eagle (Haliaeetus albicilla), being apex predators and facultative scavengers, can bioaccumulate different environmental contaminants, including toxic elements that may adversely affect their health. We analyzed the levels of cadmium (Cd), lead (Pb), and other metals and metalloids, including arsenic (As), barium (Ba), beryllium (Be), coba…
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- A review on arsenic pollution, toxicity, health risks, and management strategies using nanoremediation approaches. [Review]Rev Environ Health. 2022 Dec 26 [Online ahead of print]RE
- Over 50 countries are affected by arsenic contamination. The problem is becoming worse as the number of affected people increases and new sites are reported globally.
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- PINK1/Parkin-Mediated Mitophagy Partially Protects against Inorganic Arsenic-Induced Hepatic Macrophage Polarization in Acute Arsenic-Exposed Mice. [Journal Article]
- Inorganic arsenic is a well-known environmental toxicant and carcinogen, and there is overwhelming evidence for an association between this metalloid poisoning and hepatic diseases. However, the biological mechanism involved is not well characterized. In the present study, we probed how inorganic arsenic modulates the hepatic polarization of macrophages, as well as roles of PTEN-induced kinase 1 …
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- Arsenic-induced toxicity and the ameliorative role of antioxidants and natural compounds. [Review]J Biochem Mol Toxicol. 2022 Dec 22 [Online ahead of print]JB
- Arsenic (As) poisoning has proven to be a major threat worldwide because of its toxic effects on the human body. As toxicity through drinking water is a global health concern. The toxicity of As is known to affect the liver, kidney, lungs, muscles, cardiovascular system, and nervous system and can even induce diabetes. Further As can cause skin lesions leading to notable diseases in the skin like…
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- Thallium poisoning: a case report. [Case Reports]J Yeungnam Med Sci. 2022 Dec 15 [Online ahead of print]JY
- Thallium poisoning is usually accidental. We present a case of a 51-year-old woman who was evaluated in June 2018 for myalgia, vertigo, asthenia, and abdominal pain. Physical examination revealed temporal-spatial disorientation, jaundice, and asterixis. The laboratory reported the following: bilirubin, 10.3 mg/dL; aspartate transaminase, 78 U/L; alanine transaminase, 194 U/L; albumin, 2.3 g/dL; p…
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- Quercetin Zinc and Iron Metal Complexes Protect against Sodium Arsenite Intoxication in the Hepato-Renal System of Wistar Rats via the Oxidative Stress Pathway. [Journal Article]
- CONCLUSIONS: Quercetin zinc and iron increased the bioavailability of quercetin and therefore could be relevant as adjuvants in arsenic poisoning.
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- Mulberry leaves juice attenuates arsenic-induced neurobehavioral and hepatic disorders in mice. [Journal Article]
- Arsenic (As) poisoning has caused an environmental catastrophe in Bangladesh as millions of people are exposed to As-contaminated drinking water. Chronic As-exposure causes depression, memory impairment, and liver injury in experimental animals. This study was carried out to assess the protective effect of mulberry leaves juice (Mul) against As-induced neurobehavioral and hepatic dysfunctions in …
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- [The research progress of metabolism and occupational biological exposure index metabolism of inorganic arsenic and its compounds]. [Review]Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Nov 20; 40(11):876-880.ZL
- Arsenic is a common metal-like element. Drinking arsenic-containing water and occupational exposure to arsenic are the main ways exposure to arsenic for population. Long-term exposure to arsenic can cause various organs dysfunction and cancer. After entering the body, inorganic arsenic is mainly methylated into monomethyl arsenic and dimethyl arsenic in the liver. Only a small part of inorganic a…
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- The hypermethylation of FOXP3 gene as an epigenetic marker for the identification of arsenic poisoning risk. [Journal Article]Hum Exp Toxicol. 2022 Jan-Dec; 41:9603271221142819.HE
- Background and Purpose: Arsenic exposure can lead to skin lesions and multiple organ damage, which are not easily reversible and for which there is no effective therapeutics. Identification of reliable epigenetic markers is essential for early recognition of arsenic poisoning risk. Anomalous DNA methylation of immune homeostasis regulator FOXP3 is a critical mechanism for triggering arsenic poiso…
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- StatPearls: Rodenticide Toxicity [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Rodenticides or “rat poisons” are mixed compounds used to eradicate rodents. They are one of the most toxic agents commonly found in households. Historically, heavy metals such as arsenic were the first agents used to control rodent populations, but the most common rodenticide used in the twenty-first century is anticoagulants.[1] When a clinician suspects rodenticide poisoning, every effort shou…
- Investigation of health risk assessment and the effect of various irrigation water on the accumulation of toxic metals in the most widely consumed vegetables in Iran. [Journal Article]
- The quality of irrigation water sources can significantly affect the concentrations of heavy metals (HMs) in cultivated vegetables. This study aimed to investigate the effect of various water resources, including treated wastewater effluent (TWE), river water (RW), and well water with chemical fertilizer (WW+F), on the accumulation of heavy metals (HMs) in the three most widely consumed edible ve…
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- Keratinocyte cancer in chronic smokers: is this arsenic exposure? [Journal Article]Med J Aust. 2023 Feb 06; 218(2):68-69.MJ
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- Effects of Ozone Therapy on Chronic Arsenic Poisoning in Rats. [Journal Article]
- Arsenic (As) is a toxic metalloid that affects many organs through drinking water. This study aims to examine the efficacy of ozone therapy on chronic arsenic toxicity. Twenty-four male Wistar albino rats were housed in individual cages and grouped as control, As, O3, and As + O3. As was applied by adding 5 mg/kg/day in drinking water for 60 days. Ozone therapy was applied at 0.5 mg/kg/day (i.p.)…
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- [Advances in On-site Analytical Methods for Inorganic Arsenic in Environmental Water]. [Review]Huan Jing Ke Xue. 2022 Nov 08; 43(11):4845-4857.HJ
- Arsenic is a ubiquitous metalloid element in the environment. Arsenic is classified as a group A carcinogen and has caused serious impacts on human health. For example, chronic poisoning caused by arsenic in groundwater is a global health problem. The forms of arsenic in environmental water are diverse, which can easily be transformed into each other during the sampling process and transportation…
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- Generation of the Chemical and Social Stressors Integration Technique (CASS-IT) to identify areas of holistic public health concern: An application to North Carolina. [Journal Article]Sci Total Environ. 2023 Mar 01; 862:160409.ST
- Due to structural racism and income inequality, exposure to environmental chemicals is tightly linked to socioeconomic factors. In addition, exposure to psychosocial stressors, such as racial discrimination, as well as having limited resources, can increase susceptibility to environmentally induced disease. Yet, studies are often conducted separately in fields of social science and environmental …
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- Genome-wide DNA methylation pattern in whole blood of patients with coal-burning arsenic poisoning. [Journal Article]Ecotoxicol Environ Saf. 2022 Dec 15; 248:114323.EE
- Exposure to coal-burning arsenic leads to an increased risk of cancer, multi-systems damage and chronic diseases, with DNA methylation one potential mechanism of arsenic toxicity. There are few studies on genome-wide methylation in the coal-burning arsenic poisoning population. Illumina 850 K methylation beadchip is the most suitable technology for DNA methylation of epigenome-wide association an…
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- Investigating the synergistic role of heavy metals in Arsenic-induced skin lesions in West Bengal, India. [Journal Article]J Trace Elem Med Biol. 2023 Jan; 75:127103.JT
- CONCLUSIONS: It can be confirmed that the population from Murshidabad is exposed to As and other heavy metals through drinking water as well as food. Particularly for this population, Fe, Zn and rubidium (Rb) may play a synergistic role in arsenic-induced toxicity. However, further studies on the large population-based investigation are required to establish the chemistry of the metal toxicity.
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- Arsenic Analysis in the Petroleum Industry: A Review. [Review]
- The presence of arsenic in natural gas and liquid hydrocarbons is of great concern for oil companies. In addition to health risks due to its toxicity as well as environmental issues, arsenic is responsible for irreversible poisoning of catalysts and clogging of pipes via the accumulation of As-containing precipitates. To address these problems and to better design treatment units, robust methods …
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- Study on the Mechanism of Arsenic-Induced Lung Injury Based on SWATH Proteomics Technology. [Journal Article]
- Chronic arsenic poisoning is a global health problem that affects millions of people, and studies have found that long-term ingestion of arsenic-containing compounds can lead to lung damage, but the exact mechanism is unknown. In this study, Sprague-Dawley (SD) rats were used as the research object, and the proteomic analysis method based on sequential window acquisition of all theoretical fragme…
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- A comprehensive review of the heavy metal issues regarding commercial vanadium‑titanium-based SCR catalyst. [Review]Sci Total Environ. 2023 Jan 20; 857(Pt 3):159712.ST
- Facing the increasing demand of atmosphere pollutant control, selective catalytic reduction (SCR) technology has been widely applied in various industries for NOx abatement. However, in the condition of complicated flue gas components, the heavy metal issue is a great challenge to the catalyst deactivation and atmospheric pollution control. In this review, with the comprehensive consideration of …
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- Ayurvedic treatment induced severe alcoholic hepatitis and non-cirrhotic portal hypertension in a 14-year-old girl. [Case Reports]
- We report a novel and as yet undescribed clinical scenario in a young girl with liver failure, in whom, the liver histopathology was suggestive of alcoholic hepatitis in the background of hepatoportal sclerosis and incomplete septal cirrhosis. An extensive clinical and investigational evaluation revealed chronic consumption of multiple Ayurvedic herbal medications for seizure disease. Six months …
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- StatPearls: Cobalt Toxicity [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Cobalt (Co) metal is a gray, ductile, magnetic element with an atomic number of 27 and an atomic weight of 58.9 Da. In the environment, cobalt is a component of naturally occurring minerals and is found in combination with other elements such as copper, nickel, manganese, arsenic, sulfur, and oxygen. Due to its ferromagnetic properties, high melting point (1495.05 C), and high boiling point (2927…