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(Arthritis & inflammatory bowel disease)
14 results
  • Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis. [Journal Article]
  • ARArthritis Rheumatol 2016; 68(9):2151-62
  • Asquith MJ, Stauffer P, … Rosenbaum JT
  • CONCLUSIONS: HLA-B27/β2 m expression in this rat model renders the host hyperresponsive to microbial antigens from infancy. Early activation of innate immunity and expansion of a mucosal Th17 signature are soon followed by dysbiosis in HLA-B27/β2 m-Tg animals. The pathologic processes of perturbed mucosal immunity and dysbiosis strongly merit further study in both prediseased and diseased populations of patients with SpA.
  • Human Th17 cell clones and natural immune responses. [Review]
  • AIAllergol Int 2008; 57(2):135-40
  • Matsushita S, Higashi T
  • Immunomodulators such as lipopolysaccharides (LPS) and forskolin change the nature of dendritic cells (DCs) to induce Th1 and Th2 cells, respectively, thereby designated Th1 or Th2 adjuvants. Recent ...
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