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20,765 results
  • A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy. [Journal Article]
    Adv Healthc Mater. 2023 Jan 28 [Online ahead of print]Li C, Gong P, … Liu Z
  • Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultra-low friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions …
  • Hybrid Polylactic-Acid-Pectin Aerogels: Synthesis, Structural Properties, and Drug Release. [Journal Article]
    Polymers (Basel). 2023 Jan 12; 15(2)Horvat G, Žvab K, … Novak Z
  • Wound-dressing materials often include other materials stimulating wound healing. This research describes the first formulation of biodegradable hybrid aerogels composed of polylactic acid and pectin. The prepared hybrid material showed a highly porous structure with a surface area of 166 ± 22.6 m2·g-1. The addition of polylactic acid may have decreased the surface area of the pure pectin aerogel…
  • Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy. [Journal Article]
    Pharmaceutics. 2022 Dec 28; 15(1)Esteruelas G, Souto EB, … Sánchez-López E
  • Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suit…
  • Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins. [Journal Article]
    Int J Mol Sci. 2023 Jan 12; 24(2)Talaj JA, Zielinski K, Bujacz A
  • Free drug concentration in the blood sera is crucial for its appropriate activity. Serum albumin, the universal blood carrier protein, is responsible for transporting drugs and releasing them into the bloodstream. Therefore, a drug's binding to SA is especially important for its bioavailability and it is a key problem in the drug design process. In this paper, we present crystal structures of thr…
  • Gene Expression in MC3T3-E1 Cells Treated with Diclofenac and Methylprednisolone. [Journal Article]
    Genes (Basel). 2023 Jan 10; 14(1)Lehmann TP, Iwańczyk-Skalska E, … Głowacki M
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids (GCs) are often used to treat articular-skeletal disorders. The extended use of NSAIDs and GCs have adverse effects on bone metabolism, reducing bone quality and impairing fracture healing. In the present study, we used mouse pre-osteoblast cells MC3T3-E1 to demonstrate the effects of diclofenac (DF) and methylprednisolone (MP) on …
  • Changes in Medication Prescribing Due to COVID-19 in Dental Practice in Croatia-National Study. [Journal Article]
    Antibiotics (Basel). 2023 Jan 07; 12(1)Šutej I, Lepur D, … Peroš K
  • The 2019 coronavirus pandemic (COVID-19) has affected clinical practice and, consequently, drug prescribing in dental practice. We investigated how the pandemic affected the prescribing behavior of dentists in Croatia. Data on prescribing practices for this study were provided by the Croatian Health Insurance Institute. The analysis included the number of prescriptions, costs, and the number of p…
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