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5,111 results
  • The Prevalence of Inflammatory Bowel Disease in Greenland. [Journal Article]
    Inflamm Bowel Dis. 2023 Jan 25 [Online ahead of print]Gantzel RH, Vesterdal JD, … Pedersen ML
  • CONCLUSIONS: This study estimates the prevalence and uncovers characteristics of IBD in Greenland. Although CD may be underdiagnosed or less prevalent, the overall prevalence of IBD in Greenland parallels Scandinavian countries and North America. These results boost the knowledge on autoimmune diseases in arctic populations and may guide clinicians in their management of IBD in Greenland. Furthermore, the results may encourage research in IBD across the Arctic regions.
  • In Situ Interfacial Super-Assembly of Nanobiohybrids through Plant for Food-Grade Oral Medicine. [Journal Article]
    ACS Appl Mater Interfaces. 2023 Jan 26 [Online ahead of print]Fu W, Xie L, … Kong B
  • Developing a next-generation oral drug delivery system with enhanced efficacy and limited side effects is highly desired for refractory diseases treatment such as colitis. The bioinspired assembly of drugs within food-grade plants highlights its potential value of this unique hybrid material. Herein, we report the preparation of drug-encapsulated vegetable nanobiohybrid superassembled frameworks …
  • CMV proctitis: a rare disease presentation in a young and immunocompetent man. [Journal Article]
    BMJ Case Rep. 2023 Jan 25; 16(1)Balian S, Humm M, Haddad N
  • A young adult man presented to an outlying emergency department with a sore throat, fever and chills. Upon failure of symptomatic management and a course of amoxicillin, he developed rectal pain and loose stools. Despite outpatient doxycycline treatment for presumed chlamydial proctitis, he developed worsening rectal pain and bloody stools. Results on abdominal and pelvic CT were consistent with …
  • Mesalazine-Induced Interstitial Nephritis in a Patient With Ulcerative Colitis. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32488.da Cunha Marques J, Nogueira F, … Ribeiro AM
  • Acute interstitial nephritis (AIN) corresponds to a decline in kidney function due to an injury induced by drugs (in the majority of cases), infections, and autoimmune disorders. It is characterized by the presence of an interstitial inflammatory infiltrate in the kidney. Here, we describe a case of a man with a previous medical history relevant to ulcerative colitis (UC) who was admitted due to …
  • Mesalazine Inhibits Amyloid Formation and Destabilizes Pre-formed Amyloid Fibrils in the Human Insulin. [Journal Article]
    J Fluoresc. 2023 Jan 14 [Online ahead of print]Bardineshin F, Bahramikia S, … Hadi F
  • Amyloid formation due to protein aggregation is associated with several amyloid diseases (amyloidosis). The use of small organic ligands as inhibitors of protein aggregation is an attractive strategy for the treatment of these diseases. In the present study, we evaluated the in vitro inhibitory and destabilizing effects of Mesalazine on human insulin fibrillation. To induce fibrillation, human in…
  • Nanoparticles Obtained from Zein for Encapsulation of Mesalazine. [Journal Article]
    Pharmaceutics. 2022 Dec 16; 14(12)Lima IBC, Moreno LCGAI, … Nunes LCC
  • We encapsulated MSZ in zein nanoparticles (NP-ZN) using a desolvation method followed by drying in a mini spray dryer. These nanoparticles exhibited a size of 266.6 ± 52 nm, IPD of 0.14 ± 1.1 and zeta potential of -36.4 ± 1.5 mV, suggesting colloidal stability. Quantification using HPLC showed a drug-loaded of 43.8 µg/mg. SEM demonstrated a spherical morphology with a size variation from 220 to 4…
  • Old but Fancy: Curcumin in Ulcerative Colitis-Current Overview. [Review]
    Nutrients. 2022 Dec 09; 14(24)Pituch-Zdanowska A, Dembiński Ł, Banaszkiewicz A
  • Ulcerative colitis (UC) is one of the inflammatory bowel diseases (IBD). It is a chronic autoimmune inflammation of unclear etiology affecting the colon and rectum, characterized by unpredictable exacerbation and remission phases. Conventional treatment options for UC include mesalamine, glucocorticoids, immunosuppressants, and biologics. The management of UC is challenging, and other therapeutic…
  • Repurposing a Drug Targeting Inflammatory Bowel Disease for Lowering Hypertension. [Journal Article]
    J Am Heart Assoc. 2022 12 20; 11(24):e027893.Mei X, Mell B, … Joe B
  • Background The gut and gut microbiota, which were previously neglected in blood pressure regulation, are becoming increasingly recognized as factors contributing to hypertension. Diseases affecting the gut such as inflammatory bowel disease (IBD) present with aberrant energy metabolism of colonic epithelium and gut dysbiosis, both of which are also mechanisms contributing to hypertension. We reas…
  • [Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2022 Nov; 47(21):5863-5871.Liu YH, Rong ZL, … You Y
  • This study deciphered the mechanism of Shenling Baizhu Powder in treatment of mouse model of ulcerative colitis(UC) via NOD-like receptor thermoprotein domain 3(NLRP3) signaling pathway. After three days of adaptive feeding, 70 SPF-grade BALB/c mice were randomized into 7 groups: normal group, model group(dextran sodium sulfate, DSS), mesalazine group(DSS + 5-aminosalicylic acid, 5-ASA), NLRP3 in…
  • Retrospective investigation of mesalamine intolerance in patients with ulcerative colitis. [Journal Article]
    J Clin Biochem Nutr. 2022 Nov; 71(3):249-254.Minagawa Y, Uchiyama K, … Itoh Y
  • Mesalamine is a key drug in the treatment of ulcerative colitis (UC) for both induction and maintenance therapy. On the other hand, it is known that there are some cases of mesalamine intolerance that are difficult to distinguish from symptoms due to aggravation of UC. The aim of this study is to investigate the clinical characteristic of mesalamine intolerance in UC. A retrospective, observation…
  • Drugs and Lactation Database (LactMed): Sulfasalazine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Sulfasalazine and its active metabolite mesalamine are poorly excreted into breastmilk. However, rather high levels of the mesalamine metabolite N-acetyl-5-ASA appear in breastmilk and its effects on breastfed infants are unknown. Another sulfasalazine metabolite, sulfapyridine, also appears in milk and infant serum and might cause hemolysis, especially in newborn infants and in those with glucos…
  • Synthesis and Evaluation of NF-κB Inhibitory Activity of Mollugin Derivatives. [Journal Article]
    Molecules. 2022 Nov 16; 27(22)Zhang LH, Li MY, … Piao HR
  • (1) Background: Nuclear factor κB (NF-κB) is an important transcriptional regulator that regulates the inflammatory pathway and plays a key role in cellular inflammatory and immune responses. The presence of a high concentration of NF-κB is positively correlated with the severity of inflammation. Therefore, the inhibition of this pathway is an important therapeutic target for the treatment of var…
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