- Predictors of therapeutic failure among patients with acute brucellosis treated by dual therapy with doxycycline-rifampin. [Journal Article]
- TMTrop Med Int Health 2018 Nov 09
- CONCLUSIONS: The prevalence of therapeutic failure among the Egyptian patients with acute/subacute brucellosis is increasing. Predictors of therapeutic failure are LTBI, ascariasis, and the use of acid suppressive therapy. This article is protected by copyright. All rights reserved.
- Corrigendum: The Intestinal Roundworm Ascaris suum Releases Antimicrobial Factors Which Interfere With Bacterial Growth and Biofilm Formation. [Published Erratum]
- FCFront Cell Infect Microbiol 2018; 8:367
- [This corrects the article DOI: 10.3389/fcimb.2018.00271.].
[This corrects the article DOI: 10.3389/fcimb.2018.00271.].
- An unusual finding of obstructive jaundice-a case report and review of the literature. [Journal Article]
- OMOxf Med Case Reports 2018; 2018(11):omy088
- Biliary ascariasis is a tropical infectious disease, endemic in regions such as the Far East, Indian subcontinent and parts of the Middle East. The responsible organism is the Ascaris lumbricoides wo...
Biliary ascariasis is a tropical infectious disease, endemic in regions such as the Far East, Indian subcontinent and parts of the Middle East. The responsible organism is the Ascaris lumbricoides worm. This case study presents a 54-year-old British Caucasian female patient, admitted with a 1-week history of generalized abdominal pain. Ultrasound scan of the abdomen showed a collapsed and abnormal image of the gallbladder. Further imaging for better visualization by magnetic resonance cholangiography showed a 6 cm linear structure in the gallbladder. The morphology was characteristic of gallbladder ascariasis. Detailed history revealed that 6 months ago she had travelled to Turkey. Stool cultures confirmed the presence of ascaris eggs. She was treated conservatively with a 500 mg stat dose of Mebendazole. She was followed up in 6 weeks showing complete resolution of her symptoms.
- Ascariasis as a model to study the helminth/allergy relationships. [Journal Article]
- PIParasite Immunol 2018 Oct 08; :e12595
- Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indee...
Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and the same effects have been detected on the underlying immune responses. In this review we analyze the work on this field performed in Colombia, a Latin American tropical country, including aspects such as the molecular genetics of the IgE response to Ascaris; the allergenic activity of Ascaris IgE-binding molecular components and the immunological and clinical influences of ascariasis on asthma. The analysis allows us to conclude that the impact of ascariasis on the inception and evolution of allergic diseases such as asthma deserves more investigation, but advances have been made during the last years. The concurrent parasite-induced immunostimulatory and immunosuppressive effects during this helminthiasis do modify the natural history of asthma and some aspects of the practice of allergology in the tropics. Theoretically it can also influence the epidemiological trends of allergic diseases either by its absence or presence in different regions and countries.
- Prevalence of intestinal parasites versus knowledge, attitude and practices (KAPs) with special emphasis to Schistosoma mansoni among individuals who have river water contact in Addiremets town, Western Tigray, Ethiopia. [Journal Article]
- PlosPLoS One 2018; 13(9):e0204259
- CONCLUSIONS: High prevalence of intestinal parasitic infection was observed in Addiremets town and the most common parasites identified were S. mansoni and Hookworm. Most study participants had light infection intensity of Schistosomiasis, Ascariasis and Hookworm infection. Majority of the participants in the study area had good knowledge and positive attitude about intestinal parasitic infection and schistosomiasis control. Shells of Biomphalaria species, Bulinus species and Physa species were collected from the Mytsaeda river shore.
- Ascaris Larval Infection and Lung Invasion Directly Induces Severe Allergic Airway Disease in Mice. [Journal Article]
- IIInfect Immun 2018 Sep 24
- CONCLUSIONS: We found that Ascaris larval migration causes significant pulmonary damage, including AHR and type-2 inflammatory lung pathology that resembles an extreme form of allergic airway disease. Our findings indicate that ascariasis may be an important cause of allergic airway disease in endemic regions.
- Association of intestinal pathogens with faecal markers of environmental enteric dysfunction among slum-dwelling children in the first 2 years of life in Bangladesh. [Journal Article]
- TMTrop Med Int Health 2018; 23(11):1242-1250
- CONCLUSIONS: The study results imply the importance of intestinal pathogens in contributing to intestinal inflammation and increased intestinal permeability in young children.
- The Intestinal Roundworm Ascaris suum Releases Antimicrobial Factors Which Interfere With Bacterial Growth and Biofilm Formation. [Journal Article]
- FCFront Cell Infect Microbiol 2018; 8:271
- Ascariasis is a widespread soil-transmitted helminth infection caused by the intestinal roundworm Ascaris lumbricoides in humans, and the closely related Ascaris suum in pigs. Progress has been made ...
Ascariasis is a widespread soil-transmitted helminth infection caused by the intestinal roundworm Ascaris lumbricoides in humans, and the closely related Ascaris suum in pigs. Progress has been made in understanding interactions between helminths and host immune cells, but less is known concerning the interactions of parasitic nematodes and the host microbiota. As the host microbiota represents the direct environment for intestinal helminths and thus a considerable challenge, we studied nematode products, including excretory-secretory products (ESP) and body fluid (BF), of A. suum to determine their antimicrobial activities. Antimicrobial activities against gram-positive and gram-negative bacterial strains were assessed by the radial diffusion assay, while effects on biofilm formation were assessed using the crystal violet static biofilm and macrocolony assays. In addition, bacterial neutralizing activity was studied by an agglutination assay. ESP from different A. suum life stages (in vitro-hatched L3, lung-stage L3, L4, and adult) as well as BF from adult males were analyzed by mass spectrometry. Several proteins and peptides with known and predicted roles in nematode immune defense were detected in ESP and BF samples, including members of A. suum antibacterial factors (ASABF) and cecropin antimicrobial peptide families, glycosyl hydrolase enzymes such as lysozyme, as well as c-type lectin domain-containing proteins. Native, unconcentrated nematode products from intestine-dwelling L4-stage larvae and adults displayed broad-spectrum antibacterial activity. Additionally, adult A. suum ESP interfered with biofilm formation by Escherichia coli, and caused bacterial agglutination. These results indicate that A. suum uses a variety of factors with broad-spectrum antibacterial activity to affirm itself within its microbe-rich environment in the gut.
- Incidental diagnosis of appendiceal ascariasis during colonoscopy. [Journal Article]
- DLDig Liver Dis 2018 Jul 23
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- Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. [Journal Article]
- EEndoscopy 2018; 50(10):E292-E293