- Detection and analysis of potential drug-drug interactions among patients admitted to the cardiac care unit in a tertiary care hospital. [Journal Article]Eur Rev Med Pharmacol Sci. 2023 Jan; 27(2):737-743.ER
- CONCLUSIONS: PDDIs were common among hospitalized cardiovascular patients. PDDIs were associated with age and number of drugs prescribed. The routine integration of an online drug interactions screening tool may improve the ability of pharmacists to identify cardiac patients at higher risk of potential drug interactions and conduct appropriate interventions thereafter.
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- Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial. [Journal Article]Stroke. 2023 Feb 03 [Online ahead of print]S
- CONCLUSIONS: In patients with lacunar stroke, DAPT using cilostazol had significant benefits in reducing recurrent ischemic stroke incidence compared with SAPT without increasing the risk of severe or life-threatening bleeding.
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- A hybrid automated event adjudication system for clinical trials. [Journal Article]Clin Trials. 2023 Feb 03 [Online ahead of print]CT
- CONCLUSIONS: The automated event adjudication system in combination with human adjudicators provides a streamlined and efficient approach to event adjudication in clinical trials. To immediately apply automated event adjudication, one can first consider the automated event adjudication system and involve human assistance for cases unconfirmed by the former.
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- Treatment Outcomes of the Acute Coronary Syndrome Among Patients Attending St. Paul Hospital. [Journal Article]Ther Clin Risk Manag. 2023; 19:105-114.TC
- CONCLUSIONS: STEMI was the most common diagnosis for ACS patients at St. Paul Hospital. The two main hospital events for these patients were CHF and cardiogenic shock.
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- Low-dose aspirin in the prevention of preeclampsia in twin pregnancies: A real-world study. [Journal Article]Front Cardiovasc Med. 2022; 9:964541.FC
- CONCLUSIONS: Aspirin prescription of 75 to 100 mg in twin pregnancies was associated with no significant reduction of preeclampsia, which may be due to poor compliance with the aspirin used. Further randomized controlled or prospective cohort studies are required.
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- Allopurinol does not improve cardiovascular outcomes in ischaemic heart disease. [Journal Article]Eur Heart J. 2023 Feb 03 [Online ahead of print]EH
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- Aspirin 75 mg to prevent preeclampsia in high-risk pregnancies: a retrospective real-world study in China. [Journal Article]Eur J Med Res. 2023 Feb 02; 28(1):56.EJ
- CONCLUSIONS: Prophylaxis with 75 mg per day of aspirin in high-risk women resulted in a significantly lower incidence of PE than that in the control group.
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- Risk of post sphincterotomy bleeding with antiplatelet and anticoagulant use - A propensity-matched analysis of United States Collaborative Network. [Journal Article]Gastrointest Endosc. 2023 Jan 30 [Online ahead of print]GE
- CONCLUSIONS: Our database analysis shows that patients on AC and APT are indeed at a higher risk of post sphincterotomy bleeding, compared to matched controls. Appropriate drug cessation period or alternative biliary decompression modalities may be utilized in these patients.
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- Enhanced Thrombin Formation in Patients with Ventricular Assist Devices Experiencing Bleeding: Insights from the Multicenter PREVENT Study. [Journal Article]ASAIO J. 2022 Sep 09 [Online ahead of print]AJ
- The aim of this investigation was to characterize the hemostatic status of heart failure patients with implanted left ventricular assist devices (LVADs) to propose a mechanism associated with bleeding. Patients (n = 300) from 23 US hospitals were enrolled in the PREVENtion of HeartMate II Pump Thrombosis through Clinical Management (PREVENT) study. A biobank was established with serum and plasma …
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- Prolonged Elevations of Factor VIII and von Willebrand Factor Antigen After Multisystem Inflammatory Syndrome in Children (MIS-C). [Journal Article]J Pediatr Hematol Oncol. 2022 Oct 24 [Online ahead of print]JP
- Multisystem Inflammatory Syndrome in Children (MIS-C) is a late systemic inflammatory response to a recent mild or asymptomatic coronavirus disease of 2019 infection. The pathophysiology is incompletely understood but it often features significant coagulopathy along with cardiac and endothelial dysfunction. Endothelial inflammation has been primarily described in acute coronavirus disease of 2019…
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- Management of Anticoagulation/Antiplatelet Medication and Venous Thromboembolism Prophylaxis in Elective Spine Surgery: Concise Clinical Recommendations Based on a modified Delphi Process. [Journal Article]Spine (Phila Pa 1976). 2022 Nov 14 [Online ahead of print]S
- CONCLUSIONS: In the first known study to address anticoagulation/antiplatelet recommendations for elective spine surgery (preoperatively and postoperatively), our Delphi consensus recommendations from 20 spine surgeons achieved consensus on 26/27 items. These results will potentially help standardize the management of preoperative AC/AP medication and VTE chemoprophylaxis after adult elective spine surgery.
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- Anticoagulation for Atrial Fibrillation: A Review of Current Literature and Views. [Journal Article]Cardiol Rev. 2022 Nov 21 [Online ahead of print]CR
- Atrial fibrillation is a common supraventricular tachyarrhythmia with uncoordinated atrial activation and ineffective atrial contraction. This leads to an increased risk of atrial thrombi, most commonly in the left atrial appendage, and increased risks of embolic strokes and/or peripheral thromboembolism. It is associated with significant morbidity and mortality. To meet the concerns of thrombi a…
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- Approaches for Optimizing Venous Thromboembolism (VTE) Prevention in Injured Patients: Findings from the Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma. [Journal Article]J Trauma Acute Care Surg. 2022 Dec 06 [Online ahead of print]JT
- Venous thromboembolism (VTE) is a major issue in trauma patients. Without prophylaxis, the rate of deep venous thrombosis approaches 60%, and even with chemoprophylaxis may be nearly 30%. Advances in VTE reduction are imperative to reduce the burden of this issue in the trauma population. Novel approaches in VTE prevention may include new medications, dosing regimens, and extending prophylaxis to…
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- Monitoring antiplatelet therapy: where are we now? [Journal Article]J Cardiovasc Med (Hagerstown). 2022 Dec 15 [Online ahead of print]JC
- Single antiplatelet therapy represents the cornerstone of thrombosis prevention in atherosclerotic cardiovascular disease. Dual antiplatelet therapy (DAPT), consisting of aspirin plus a P2Y12 inhibitor, is the standard of care for patients with acute coronary syndrome or undergoing both coronary and peripheral percutaneous interventions. Recent data suggest the efficacy of DAPT also after minor s…
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- Trends of Venous Thromboembolism After Total Hip Arthroplasty in the United States: Analysis From 2011 to 2019. [Journal Article]J Am Acad Orthop Surg. 2023 Jan 18 [Online ahead of print]JA
- CONCLUSIONS: Since 2011, the incidence and economic burden associated with VTE after THA have significantly declined. In addition, there has been an increase in prescription aspirin and direct oral anticoagulants.
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- Trends in Venous Thromboembolism After Shoulder Arthroplasty in the United States: Analysis Following the 2009 American Academy of Orthopaedic Surgeons Clinical Practical Guidelines. [Journal Article]J Am Acad Orthop Surg. 2023 Jan 19 [Online ahead of print]JA
- CONCLUSIONS: The incidence and economic burden associated with VTE after TSA have markedly declined following the 2010 American Academy of Orthopaedic Surgeons clinical practice guidelines. This reduction can be attributed to both an increase in VTE prevention through increased utilization of prescribed chemoprophylaxis and improvement in VTE treatment strategies.
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- Infarct Size and Long-Term Clinical Outcomes of Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndrome Undergoing Coronary Artery Stenting: A Prospective Randomized Study. [Journal Article]
- The antiplatelet drug prasugrel inhibits platelet aggregation early after oral administration. This study examined whether prasugrel is effective in inhibiting infarct size and can reduce the incidence of major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). This study was a single-center, prospective, randomized pilot study. Among 80 ACS patients treated at o…
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- NHANES cross sectional study of aspirin and fractures in the elderly. [Journal Article]
- Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number o…
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- Clinical Impact of Additional Cilostazol Treatment on Restenosis Risk following Heparin-Bonded Stent Graft Implantation: Sub-Analysis from the Viabahn Stent-Graft Placement for Femoropopliteal Diseases Requiring Endovascular Therapy (VANQUISH) Study. [Journal Article]J Atheroscler Thromb. 2023 Feb 02 [Online ahead of print]JA
- CONCLUSIONS: Our study revealed the clinical impact of additional cilostazol treatment on the risk of restenosis and acute thrombotic occlusion following heparin-bonded stent graft implantation, while TLR and surgical reconstruction were not significantly different.
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- Gender differences in cardiovascular risk, treatment, and outcomes: a post hoc analysis from the REWIND trial. [Randomized Controlled Trial]Scand Cardiovasc J. 2023 Dec; 57(1):2166101.SC
- Objectives. To assess whether the use of cardioprotective therapies for type 2 diabetes varies by gender and whether the risk of cardiovascular events is higher in women versus men in the REWIND trial, including an international type 2 diabetes patient population with a wide range of baseline risk. Design. Gender differences in baseline characteristics, cardioprotective therapy, and the achieved …
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- Surface Coating of Polyurethane Films with Gelatin, Aspirin and Heparin to Increase the Hemocompatibility of Artificial Vascular Grafts. [Journal Article]
- Purpose: A hemocompatible substrate can offer a wonderful facility for nitric oxide (NO) production by vascular endothelial cells in reaction to the inflammation following injuries. NO inhibits platelet aggregation this is especially critical in small-diameter vessels. Methods: The substrate films were made of polyurethane (PU) in a casting process and after plasma treatments, their surface was c…
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- Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8. [Journal Article]
- CONCLUSIONS: In CRSwNP, there is a reduction in IL-8 and IL-12 subunits compared to control, with a lack of correlation between IL-12 and IL-8. The lack of correlation can be justified by a type two inflammatory storm environment.
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- Dual Antiplatelet Therapy Does Not Increase Bleeding Risk in Percutaneous Gastrostomy Tube Placement: Network Meta-Analysis. [Journal Article]Dig Dis Sci. 2023 Jan 31 [Online ahead of print]DD
- CONCLUSIONS: There is no significant difference in bleeding risk between DAPT, single antiplatelet or no antiplatelet therapy on a population level. On an individual level, risk of ischemic events should be weighed against the risk of bleeding based on patient circumstances and risk profile. Our findings offer to provide additional data to make an informed decision between patients and physicians to make clinical decisions by assessing individual risks and benefits for optimal care of complex patients.
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- Adrenal insufficiency revealing bilateral adrenal hemorrhage related to JAK2 V617F-positive essential thrombocythemia: about two cases. [Journal Article]Blood Coagul Fibrinolysis. 2023 Jan 23 [Online ahead of print]BC
- Bilateral adrenal hemorrhage is a rare cause of adrenal insufficiency which has been rarely associated with myeloproliferative neoplasms. Here, we report two cases of bilateral adrenal hemorrhage revealed by abdominal pain, malaise, and fatigue in two octogenarian males previously diagnosed with JAK2 V617F-positive essential thrombocythemia. Both patients were on long-term direct oral anticoagula…
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- SNOT-22 scores after 6 months of aspirin therapy are predictive of long-term quality of life in AERD. [Journal Article]Allergy Asthma Proc. 2023 Jan 01; 44(1):78-80.AA
- Background: Aspirin exacerbated respiratory disease (AERD) is an inflammatory condition that consists of eosinophilic asthma, chronic rhinosinusitis with nasal polyps, and respiratory reactions to cyclooxygenase-1 inhibitors. Aspirin therapy after aspirin desensitization (ATAD) is the most extensively studied treatment paradigm for AERD. Objective: The objective was to identify which time point o…
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- Acetylsalicylic Acid (aspirin) for Primary Prevention of Cardiovascular Events in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [Meta-Analysis]Curr Vasc Pharmacol. 2023 Jan 31 [Online ahead of print]CV
- CONCLUSIONS: Aspirin use in patients with DM reduces the composite endpoint of CV death, non-fatal MI and stroke compared with a placebo. However, routine use of aspirin for primary prevention among diabetic patients cannot be advised due to the increased risk of major bleeding. These findings suggest careful risk assessment of individual patients.
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- Repurposing some of the Well-Known Non-Steroid Anti-Inflammatory Drugs [Nsaids] for Cancer Treatment. [Journal Article]Curr Top Med Chem. 2023 Jan 30 [Online ahead of print]CT
- Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the drug-repurposing strategy is time-saving, and inexpensive. It has a higher success rate compared to traditional drug discovery. Several repurposing…
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- A randomized controlled trial to evaluate outcomes with Aggrenox in patients with SARS-CoV-2 infection. [Randomized Controlled Trial]
- CONCLUSIONS: In this study of hospitalized patients with COVID-19, while the outcomes of COVID illness severity, odds of mortality, and chance of respiratory failure were better in the Aggrenox group compared to standard of care alone, the data did not reach statistical significance to support the standard use of adjuvant Aggrenox in such patients.
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- Effects of a Polypill, Aspirin, and the Combination of Both on Cognitive and Functional Outcomes: A Randomized Clinical Trial. [Journal Article]JAMA Neurol. 2023 Jan 30 [Online ahead of print]JN
- CONCLUSIONS: In this randomized clinical trial of patients 65 years or older with vascular risk factors, a polypill, with or without aspirin, was not associated with reduced cognitive outcomes but was associated with reduced functional decline.
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- Aspirine en prévention cardiovasculaire : faut-il dépister Helicobacter pylori ? [News]Rev Med Suisse. 2023 01 25; 19(811):150.RM
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