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483 results
  • Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. [Journal Article]
    J Emerg Med. 2022 Nov 27 [Online ahead of print]Matsuoka M, Imai T, … Kinoshita K
  • Amoxapine is a second-generation tricyclic antidepressant with a greater seizure risk than other antidepressants. If administered in large amounts, amoxapine can cause severe toxicity and death. Therefore, it is necessary to terminate seizures immediately if amoxapine toxicity occurs. However, intractable seizures often occur in these patients. We describe a case of intractable seizures caused by…
  • StatPearls: Amoxapine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)AbbasSayedaSAvalon University School of MedicineMarwahaRamanRCase Western Reserve Un/MetroHealth MCBOOK
  • Amoxapine is an FDA-approved drug belonging to the class of second-generation tricyclic dibenzoxazepine antidepressants. Generally, it is reserved for resistant or persistent depression. The goal of this activity is to familiarize practitioners with the proper usage of this drug and recognize the adverse effects of this medication. This activity also explores the roles of a cohesive interprofessi…
  • Drugs and Lactation Database (LactMed): Amoxapine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because there is no published experience with amoxapine during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.
  • Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice. [Journal Article]
    J Toxicol Sci. 2022; 47(3):99-108.Inoue Y, Kaizaki-Mitsumoto A, Numazawa S
  • In the event of an overdose, the pharmacokinetics of the drug may be altered, resulting in an unexpectedly rapid increase in blood and tissue drug concentrations. Because central nervous system (CNS)-acting drugs are the major cause of hospitalization for overdose, brain concentrations, which are closely related to the development of acute psychotropic symptoms, would be important. However, due t…
  • Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis. [Journal Article]
    Neurotherapeutics. 2021 07; 18(3):1678-1691.Fiscon G, Conte F, … Paci P
  • The continuous adherence to the conventional "one target, one drug" paradigm has failed so far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases as amyotrophic lateral sclerosis (ALS), a rare progressive and chronic, debilitating neurological disease for which no cure is available. The present study is aimed at finding innovative solutions and paradigms for …
  • Recent advances in the synthesis of piperazine based ligands and metal complexes and their applications. [Review]
    Dalton Trans. 2021 Jan 21; 50(3):785-800.Kant R, Maji S
  • The piperazine scaffold is a privileged structure frequently found in biologically active compounds. Piperazine nucleus is found in many marketed drugs in the realm of antidepressants (amoxapine), antipsychotics (bifeprunox), antihistamines (cyclizine and oxatomide), antifungals (itraconazole), antibiotics (ciprofloxacin), etc. This is one of the reasons why piperazine based compounds are gaining…
  • Interactions of antiepileptic drugs with drugs approved for the treatment of indications other than epilepsy. [Review]
    Expert Rev Clin Pharmacol. 2020 Dec; 13(12):1329-1345.Borowicz-Reutt KK, Czuczwar SJ, Rusek M
  • Introduction: Comorbidities of epilepsy may significantly interfere with its treatment as diseases in the general population are also encountered in epilepsy patients and some of them even more frequently (for instance, depression, anxiety, or heart disease). Obviously, some drugs approved for other than epilepsy indications can modify the anticonvulsant activity of antiepileptics. Areas covered:…
  • Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice. [Journal Article]
    Chem Pharm Bull (Tokyo). 2020; 68(9):848-854.Saito K, Hagiwara N, … Hosoe T
  • The degradation behavior of eight tricyclic antidepressants (TCAs; amitriptyline, amoxapine (AMX), imipramine, clomipramine, desipramine, doxepin, dothiepin, and nortriptyline) in artificial gastric juice was investigated to estimate their pharmacokinetics in the stomach. As a result, among the eight TCAs, only AMX was degraded in artificial gastric juice. The degradation was a pseudo first-order…
  • Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database. [Journal Article]
    BMC Psychiatry. 2020 Jun 16; 20(1):308.Revet A, Montastruc F, … Nguyen TTH
  • CONCLUSIONS: A potential harmful association was found between movement disorders and use of the antidepressants mirtazapine, vortioxetine, amoxapine, phenelzine, tryptophan, fluvoxamine, citalopram, paroxetine, duloxetine, bupropion, clomipramine, escitalopram, fluoxetine, mianserin, sertraline, venlafaxine and vilazodone. Clinicians should beware of these adverse effects and monitor early warning signs carefully. However, this observational study must be interpreted as an exploratory analysis, and these results should be refined by future epidemiological studies.
  • Effect of Antidepressants on Psychotic Symptoms in Parkinson Disease: A Review of Case Reports and Case Series. [Review]
    Clin Neuropharmacol. 2020 May/Jun; 43(3):61-65.Sid-Otmane L, Huot P, Panisset M
  • CONCLUSIONS: Whereas the conclusions that can be drawn on the efficacy of antidepressants at reducing PD psychosis are limited because of the poor quality of the reported studies, it is encouraging to notice that there are positive anecdotal reports. Further studies are needed to confirm the potential of these drugs and also to determine if a subtype of patients or of psychotic features may be more likely to be improved by antidepressants.
  • Association of sleep among 30 antidepressants: a population-wide adverse drug reaction study, 2004-2019. [Journal Article]
    PeerJ. 2020; 8:e8748.Eugene AR
  • CONCLUSIONS: Among the thirty tested antidepressants, consistent with the original hypothesis, amoxepine has strongest 5-HT2C receptor binding affinity and has the highest reporting odds of somnolence. Atomoxetine, ranked second in reporting odds of somnolence overall, binds to the NET with with the strongest binding affinity among the thirty compounds. Mirtazapine, a tetracyclic antidepressant, was ranked 11th in reporting odds of somnolence and had the strongest H1 receptor binding affinity. This study provides an informative ranking of somnolence among thirty antidepressant compounds with an already wide array of clinical indications as well as provides insight into potential drug repurposing in psychopharmacology.
  • Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. [Journal Article]
    Mol Psychiatry. 2019 04; 24(4):501-522.Niculescu AB, Le-Niculescu H, … White FA
  • We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increased perception of pain. For discovery, we used a powerful within-subject longitudinal design. We we…
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