- Epidemiological Trends in Nontuberculous Mycobacterial Infection among People with Cystic Fibrosis in Germany. [Journal Article]Int J Infect Dis. 2023 Jan 31 [Online ahead of print]IJ
- CONCLUSIONS: The NTM burden in pwCF in Germany remained unchanged between 2016 and 2020. MABC was the dominant species detected, whereas only MAC infections increased with time and age. The known association of Aspergillus fumigatus and NTM was reaffirmed. Awareness of NTM needs to be improved.
- Publisher Full Text (DOI)
- In vitro and in vivo evaluation of antifungal combinations against azole-resistant Aspergillus fumigatus isolates. [Journal Article]Front Cell Infect Microbiol. 2022; 12:1038342.FC
- Azole resistance in Aspergillus fumigatus (Af) has become a widespread threat and a major concern for optimal management of patients with invasive aspergillosis (IA). Combination of echinocandins with azoles is an attractive alternative option for the treatment of IA due to azole-resistant Af strains. The aim of this study was to evaluate the in vitro and in vivo combination of caspofungin (CAS) …
- PMC Free PDF
- Bilateral renal aspergillosis with a fungal cast masquerading as renal malignancy. [Journal Article]BMJ Case Rep. 2023 Feb 02; 16(2)BC
- Invasive isolated renal aspergilloma in an immunocompetent host is rare, and few cases have been reported in the literature. It is a unique entity encountered by a urologist that can lead to catastrophic complications like end-stage renal disease. Infective pathology may closely resemble renal mass, and timely, appropriate investigations are obligatory for early intervention. This case report hig…
- Publisher Full Text (DOI)
- Successful and Safe Real-Time TDM-Guided Treatment of Invasive Pulmonary and Cerebral Aspergillosis Using Low-Dose Isavuconazole in a Patient with Primary Biliary Cirrhosis: Grand Round/A Case Study. [Journal Article]Ther Drug Monit. 2023 Jan 03 [Online ahead of print]TD
- CONCLUSIONS: TDM-guided clinical pharmacological advice was essential for the successful and safe management of isavuconazole treatment in this patient with moderate liver dysfunction.
- Publisher Full Text (DOI)
- Siderophore-Based Noninvasive Differentiation of Aspergillus fumigatus Colonization and Invasion in Pulmonary Aspergillosis. [Journal Article]Microbiol Spectr. 2023 Jan 31 [Online ahead of print]MS
- Germination from conidia to hyphae and hyphal propagation of Aspergillus fumigatus are the key pathogenic steps in the development of invasive pulmonary aspergillosis (IPA). By applying in vitro observations in a clinical study of 13 patients diagnosed with probable IPA, here, we show that the transition from colonization to the A. fumigatus invasive stage is accompanied by the secretion of triac…
- Publisher Full Text (DOI)
- Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020. [Journal Article]Med Mycol. 2023 Jan 28 [Online ahead of print]MM
- Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole-genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged fr…
- Publisher Full Text (DOI)
- Immunogenicity and protective efficacy of a pan-fungal vaccine in preclinical models of aspergillosis, candidiasis, and pneumocystosis. [Journal Article]
- Invasive fungal infections cause over 1.5 million deaths worldwide. Despite increases in fungal infections as well as the numbers of individuals at risk, there are no clinically approved fungal vaccines. We produced a "pan-fungal" peptide, NXT-2, based on a previously identified vaccine candidate and homologous sequences from Pneumocystis, Aspergillus,Candida, and Cryptococcus. We evaluated the i…
- PMC Free PDF
- The Impact of Chronic Pulmonary Aspergillosis Co-infection on the Health-Related Quality of Life of Patients with Pulmonary Tuberculosis in Uganda. [Preprint]Res Sq. 2023 Jan 13RS
- Background Both pulmonary tuberculosis (PTB) and chronic pulmonary aspergillosis (CPA) significantly affect health-related quality of life (HR-QoL). We aimed to determine the impact of CPA co-infection on the HR-QoL of Ugandans with PTB. Methods We conducted a prospective study among participants with PTB with persistent pulmonary symptoms after 2 months of anti-TB treatment at Mulago Hospital, K…
- PMC Free PDF
- Aspergillus infection in chronic obstructive pulmonary diseases. [Review]Clin Respir J. 2023 Jan 29 [Online ahead of print]CR
- Chronic obstructive pulmonary disease (COPD) is a chronic airway non-specific inflammatory disease characterised by airway obstruction and alveolar destruction. In recent years, due to the extensive use of antibiotics, glucocorticoids, immunosuppressants and other drugs, pulmonary fungal infection in patients with AECOPD, especially aspergillus infection, has gradually increased. The forms of asp…
- Publisher Full Text (DOI)
- Investigation of predictors for invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome. [Journal Article]
- Patients with severe fever with thrombocytopenia syndrome (SFTS) had been confirmed to have immune dysfunction and were prone to invasive pulmonary aspergillosis (IPA), which was directly related to the increased mortality. The aim of this study was to investigate the predictors for IPA in SFTS patients, and the results were expected to be helpful for early identification of IPA and initiation of…
- PMC Free PDF
- Allergic Bronchopulmonary Aspergillosis in Identical Twins: Effectiveness of Dupilumab. [Journal Article]J Allergy Clin Immunol Pract. 2023 Jan 24 [Online ahead of print]JA
- Publisher Full Text (DOI)
- Analysis of risk factors of fungal superinfections in viral pneumonia patients: A systematic review and meta-analysis. [Meta-Analysis]
- CONCLUSIONS: Our research shows that corticosteroid treatment was an important risk factor for the development of fungal infection in patients with viral pneumonia. High APACHE II scores, tumors, and immunocompromised condition are also important risk factors of developing IPA. The diagnosis of fungal infection in viral pneumonia patients can be facilitated by early serum galactomannan (GM) testing, bronchoalveolar lavage fluid Aspergillus antigen testing, culture, and biopsy.
- PMC Free PDF
- [Translated article] Therapeutic drug monitoring of voriconazole in a rapid-metabolizer patient with invasive pulmonary aspergillosis. [Case Reports]Farm Hosp. 2023 Jan 24 [Online ahead of print]FH
- Publisher Full Text (DOI)
- Defining the Outcome Markers and Therapeutic Role for Omalizumab in Treatment of Allergic Bronchopulmonary Aspergillosis. [Editorial]J Allergy Clin Immunol Pract. 2023 Jan 24 [Online ahead of print]JA
- Publisher Full Text (DOI)
- Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis. [Journal Article]J Clin Invest. 2023 Jan 26 [Online ahead of print]JCI
- CONCLUSIONS: Our data highlight the development of heterogenous Th responses targeting different protein fractions of a single fungal pathogen and identify the development of multispecies cross-reactive Th2-cells as a potential risk factor for ABPA.
- Publisher Full Text (DOI)
- Prevention of acquired invasive fungal infection with decontamination regimen in mechanically ventilated ICU patients: a pre/post observational study. [Journal Article]Infect Dis (Lond). 2023 Jan 24 [Online ahead of print]ID
- CONCLUSIONS: Acquired fungal infection is a rare event, but accounts for a large proportion of ICU-acquired infections. Our study showed a preventive effect of decontamination against acquired fungal infection, especially candidemia.Take home messageAcquired fungal infection (AFI) incidence is close to 4% in mechanically ventilated patients without antifungal prophylaxis (3% for pulmonary aspergillosis and 1% for candidemia).Aspergillosis accounts for 14% of ventilator-associated pneumonia and candidemia for 9% of acquired bloodstream infections.Immunocompromised patients, those infected with SARS-COV 2 or influenza virus, males and patients admitted during the fall season are at higher risk of AFI.Mechanically ventilated patients receiving multiple site decontamination (MSD) have a lower risk of AFI.
- Publisher Full Text (DOI)
- Cerebral aspergillosis after heart-lung transplantation in a child: Case report with 3-year follow-up and literature review. [Case Reports]
- There are limited cases of heart-lung transplantation (HLT) in children worldwide owing to lack of donors, demanding surgical teamwork, and arduous post-operative management. Post-transplant management difficulties stem from the possible development of several post-operative complications, with infection being a common complication. Intracranial fungal infections are difficult to diagnose and pro…
- PMC Free PDF
- Anti-fungal therapy: An overview for maxillofacial surgeons in post-covid-19 fungal infections. [Review]
- India is well known as the diabetes "capital" of the world but now it is also becoming the mucormycosis "capital" of the world. Indian Council of Medical Research has formed an "Evidence-Based Advisory in The Time of COVID-19 on Screening, Diagnosis, and Management of Mucormycosis." As per this advisory, an oral and maxillofacial surgeon forms an integral part of the team dedicated to fight this …
- PMC Free PDF
- Diagnosis, prognosticators, and management of acute invasive fungal rhinosinusitis: multidisciplinary consensus statement and Evidence-Based review with recommendations. [Journal Article]Int Forum Allergy Rhinol. 2023 Jan 21 [Online ahead of print]IF
- CONCLUSIONS: Based on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms. This article is protected by copyright. All rights reserved.
- Publisher Full Text (DOI)
- Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections. [Review]
- Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant…
- PMC Free PDF
- Invasive Fungal Infections in Hospitalized Patients with COVID-19: A Non-Intensive Care Single-Centre Experience during the First Pandemic Waves. [Journal Article]
- Invasive fungal infections (IFIs) represent a severe complication of COVID-19, yet they are under-estimated. We conducted a retrospective analysis including all the COVID-19 patients admitted to the Infectious Diseases Unit of the Federico II University Hospital of Naples until the 1 July 2021. Among 409 patients, we reported seven cases of IFIs by Candida spp., seven of Pneumocystis jirovecii pn…
- PMC Free PDF
- Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals. [Journal Article]
- Allergic asthma has traditionally been treated with inhaled and systemic glucocorticosteroids. A continuum of allergic fungal airways disease associated with Aspergillus fumigatus colonization and/or atopic immune responses that encompasses fungal asthma, severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis is now recognized along a phenotypic severity spectrum of T…
- PMC Free PDF
- COVID-19-Associated Pulmonary Aspergillosis (CAPA) in Northern Greece during 2020-2022: A Comparative Study According to the Main Consensus Criteria and Definitions. [Journal Article]
- Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) has emerged as an important complication among patients with acute respiratory failure due to SARS-CoV-2 infection. Almost 2.5 years since the start of the COVID-19 pandemic, it continues to raise concerns as an extra factor that contributes to increased mortality, which is mostly because its diagnosis and management re…
- PMC Free PDF
- Aspergillus spp. Isolated from Lungs of Poultry (Gallus gallus) at the Mycology Laboratory, School of Veterinary Medicine, Universidad Nacional, Heredia, Costa Rica between 2008 and 2021 and Associated Factors. [Journal Article]
- Aspergillosis is a disease caused by some species of the fungus Aspergillus, occurring in both mammals (including humans) and birds, the latter being the most susceptible group. Aspergillus must be considered a public health concern as it affects the poultry industry economically and is an occupational risk to its workers. A retrospective study of fungal isolates from the lungs of chickens (Gallu…
- PMC Free PDF
- Specific Focus on Antifungal Peptides against Azole Resistant Aspergillus fumigatus: Current Status, Challenges, and Future Perspectives. [Review]
- The prevalence of fungal infections is increasing worldwide, especially that of aspergillosis, which previously only affected people with immunosuppression. Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis and endangers public health due to resistance to azole-type antimycotics such as fluconazole. Antifungal peptides are viable alternatives that combat infection by forming…
- PMC Free PDF
- Importance of Aspergillus-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana. [Journal Article]
- Chronic pulmonary aspergillosis (CPA) often occurs in patients that have been previously treated for pulmonary tuberculosis (PTB). A limited number of studies have looked at the development of CPA at different times following the completion of a PTB treatment course. This prospective longitudinal study aimed to determine the incidence of CPA at two timepoints, at the end of the PTB treatment (T1)…
- PMC Free PDF
- The Comparative Evaluation of the Fujifilm Wako β-Glucan Assay and Fungitell Assay for Diagnosing Invasive Fungal Disease. [Journal Article]
- Serum 1,3-β-d-glucan(BDG) is a broad fungal biomarker for invasive fungal disease (IFD). More data is still required to support the Fujifilm Wako assay as a valuable alternative to the widely used Fungitell assay. We included archived serum samples from 157 individuals (97 cases; 33-IA, 64-IC, and 60 controls) for the comparative performance evaluation of the Fungitell assay and the Fujifilm Wako…
- PMC Free PDF
- Health economic analysis of patients treated with isavuconazole in a German comprehensive cancer centre. [Journal Article]Mycoses. 2023 Jan 20 [Online ahead of print]M
- CONCLUSIONS: Treating IFD is resource intensive, often requires intensive care and implies high rates of in-hospital mortality. Our study emphasises the high hospital treatment costs and thus the need for reimbursement systems to enable live-saving costly treatments.
- Publisher Full Text (DOI)