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Unbound Medicine.
(Aspergillosis)
22,749 results
  • Bilateral renal aspergillosis with a fungal cast masquerading as renal malignancy. [Journal Article]
    BMJ Case Rep. 2023 Feb 02; 16(2)Tosh JM, Navriya SC, … Jain N
  • Invasive isolated renal aspergilloma in an immunocompetent host is rare, and few cases have been reported in the literature. It is a unique entity encountered by a urologist that can lead to catastrophic complications like end-stage renal disease. Infective pathology may closely resemble renal mass, and timely, appropriate investigations are obligatory for early intervention. This case report hig…
  • Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020. [Journal Article]
    Med Mycol. 2023 Jan 28 [Online ahead of print]Misas E, Deng JZ, … Chow NA
  • Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole-genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged fr…
  • Aspergillus infection in chronic obstructive pulmonary diseases. [Review]
    Clin Respir J. 2023 Jan 29 [Online ahead of print]Guo L, Wu X, Wu X
  • Chronic obstructive pulmonary disease (COPD) is a chronic airway non-specific inflammatory disease characterised by airway obstruction and alveolar destruction. In recent years, due to the extensive use of antibiotics, glucocorticoids, immunosuppressants and other drugs, pulmonary fungal infection in patients with AECOPD, especially aspergillus infection, has gradually increased. The forms of asp…
  • Prevention of acquired invasive fungal infection with decontamination regimen in mechanically ventilated ICU patients: a pre/post observational study. [Journal Article]
    Infect Dis (Lond). 2023 Jan 24 [Online ahead of print]Massart N, Reizine F, … Fillatre P
  • CONCLUSIONS: Acquired fungal infection is a rare event, but accounts for a large proportion of ICU-acquired infections. Our study showed a preventive effect of decontamination against acquired fungal infection, especially candidemia.Take home messageAcquired fungal infection (AFI) incidence is close to 4% in mechanically ventilated patients without antifungal prophylaxis (3% for pulmonary aspergillosis and 1% for candidemia).Aspergillosis accounts for 14% of ventilator-associated pneumonia and candidemia for 9% of acquired bloodstream infections.Immunocompromised patients, those infected with SARS-COV 2 or influenza virus, males and patients admitted during the fall season are at higher risk of AFI.Mechanically ventilated patients receiving multiple site decontamination (MSD) have a lower risk of AFI.
  • Anti-fungal therapy: An overview for maxillofacial surgeons in post-covid-19 fungal infections. [Review]
    Natl J Maxillofac Surg. 2022 Sep-Dec; 13(3):330-336.Datarkar A, Bhawalkar A, … Walkey D
  • India is well known as the diabetes "capital" of the world but now it is also becoming the mucormycosis "capital" of the world. Indian Council of Medical Research has formed an "Evidence-Based Advisory in The Time of COVID-19 on Screening, Diagnosis, and Management of Mucormycosis." As per this advisory, an oral and maxillofacial surgeon forms an integral part of the team dedicated to fight this …
  • Diagnosis, prognosticators, and management of acute invasive fungal rhinosinusitis: multidisciplinary consensus statement and Evidence-Based review with recommendations. [Journal Article]
    Int Forum Allergy Rhinol. 2023 Jan 21 [Online ahead of print]Roland LT, Humphreys IM, … Kuan EC
  • CONCLUSIONS: Based on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms. This article is protected by copyright. All rights reserved.
  • Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections. [Review]
    Pharmaceutics. 2023 Jan 12; 15(1)de Almeida Campos L, Fin MT, … Mendes-Giannini MJS
  • Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant…
  • Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals. [Journal Article]
    J Fungi (Basel). 2023 Jan 06; 9(1)Moss RB
  • Allergic asthma has traditionally been treated with inhaled and systemic glucocorticosteroids. A continuum of allergic fungal airways disease associated with Aspergillus fumigatus colonization and/or atopic immune responses that encompasses fungal asthma, severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis is now recognized along a phenotypic severity spectrum of T…
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