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Unbound Medicine.
(Assisted reproductive technologies)
82,754 results
  • Landscape of pathogenic mutations in premature ovarian insufficiency. [Journal Article]
    Nat Med. 2023 Feb 02 [Online ahead of print]Ke H, Tang S, … Chen ZJ
  • Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To identify genetic variants associated with POI, here we performed whole-exome sequencing in a cohort of 1,030 patients with POI. We detected 195 pathogenic/likely pathogenic variants in 59 known POI-causative…
  • Effect of PFOA exposure on diminished ovarian reserve and its metabolism. [Journal Article]
    Reprod Biol Endocrinol. 2023 Feb 01; 21(1):16.Shen H, Gao M, … Zhang X
  • Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction. This study aimed to examine the effect of PFOA concentration in follicular fluid during ovulation stimulation on embryo quality and the impact of PFOA exposure on the metabolic components of follicular fluid. This was a single-center prospective study …
  • A microfluidic method for passive trapping of sperms in microstructures. [Journal Article]
    Lab Chip. 2023 Jan 30 [Online ahead of print]Nath B, Caprini L, … Puglisi A
  • Sperm motility is a prerequisite for male fertility. Enhancing the concentration of motile sperms in assisted reproductive technologies - for human and animal reproduction - is typically achieved through aggressive methods such as centrifugation. Here, we propose a passive technique for the amplification of motile sperm concentration, with no externally imposed forces or flows. The technique is b…
  • Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after in vitro fertilization. [Journal Article]
    Front Endocrinol (Lausanne). 2022; 13:1062303.Ge Y, Lai S, … Zhao J
  • CONCLUSIONS: IUH was a risk factor for VTS in twin pregnancies following double embryo transfer and elevated the risks of threatened abortion, preterm birth, and postpartum hemorrhage in the surviving singleton. The absence of fetal cardiac activities at the diagnosis of IUH elevated the risks of VTS, while an IUH with an increasing volume was associated with threatened abortion without elevating the risks of VTS. An IUH diagnosed before the presence of fetal cardiac activities also resulted in an earlier miscarriage. The study suggests that attention be paid to twin pregnancies with first-trimester IUH to prevent VTS and subsequent adverse perinatal outcomes.
  • Stop GnRH-agonist/GnRH-antagonist protocol: a different insight on ovarian stimulation for IVF. [Review]
    Reprod Biol Endocrinol. 2023 Jan 30; 21(1):13.Orvieto R
  • Ovarian stimulation (OS) is one of the key factors in the success of in vitro fertilization-embryo transfer (IVF-ET), by enabling the recruitment of numerous healthy fertilizable oocytes and, thereby, multiple embryos. The Stop GnRH-agonist/GnRH-antagonist (GnRH-ag/GnRH-ant), which offers all the advantages of using long suppressive GnRH-ag, with GnRH-ant, is in my opinion a valuable addition to …
  • Expecting more: the case for incorporating fertility services into comprehensive sickle cell disease care. [Review]
    Lancet Haematol. 2023 Jan 25 [Online ahead of print]Pecker LH, Oteng-Ntim E, … Mishkin AD
  • Assisted reproductive technologies (ART) are not yet systematically available to people with sickle cell disease or their parents. Fertility care for these groups requires addressing sickle cell disease-associated infertility risks, fertility preservation options, pregnancy possibilities and outcomes, and, when needed, infertility treatment. People with a chance of having a child with sickle cell…
  • Oxidative homeostasis in follicular fluid and reproductive outcomes - from bench to bedside. [Review]
    Prz Menopauzalny. 2022 Dec; 21(4):276-284.Zec I, Goldštajn MŠ, … Laganà AS
  • Free radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological conditions in female reproduction and its potential effect on IVF outcome. A review of the literature was…
  • A Bayesian network model for prediction of low or failed fertilization in assisted reproductive technology based on a large clinical real-world data. [Journal Article]
    Reprod Biol Endocrinol. 2023 Jan 26; 21(1):8.Tian T, Kong F, … Qiao J
  • CONCLUSIONS: First, our study was based on clinical data from a single center, and the results of this study should be further verified by external data. In addition, some critical data (e.g., the detailed IVF laboratory parameters of the sperm and oocytes used for insemination) were not available in this study, which should be given full consideration when further improving the performance of the BN model.Based on extensive clinical real-world data, we developed a BN model to predict the probabilities of fertilization failures in ART, which provides new clues for clinical decision-making support for clinicians in formulating personalized treatment plans and further improving ART treatment outcomes.
  • Cross-species comparison of mouse and human preimplantation development with an Emphasis on Lineage Specification. [Review]
    Reproduction. 2023 Jan 01 [Online ahead of print]Biondic S, Canizo J, … Petropoulos S
  • Preimplantation development is arguably one of the most critical stages of embryogenesis. Beginning with the formation of the totipotent zygote post-fertilization, a series of cell divisions and a complex coordination of physical cues, molecular mechanisms and changes in gene expression lead to the formation of the blastocyst, a structure capable of implanting into the uterine wall. The blastocys…
  • GVBD rate is an independent predictor for pregnancy in ICSI patients with surplus immature oocytes. [Journal Article]
    Front Endocrinol (Lausanne). 2022; 13:1022044.Wang M, Yang Q, … Jin L
  • CONCLUSIONS: In conclusion, GVBD rate and progesterone level on HCG day may be associated with pregnancy outcomes in infertile couples during the regular ICSI procedure. An elevated GVBD rate within 24 h may greatly increase the likelihood of pregnancy in infertile couples during ICSI. This preliminary study may optimize clinical pregnancy prediction, which provides support in decision-making in clinical practice.
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