- CADTH Canadian Drug Expert Committee Recommendation: Fluticasone Propionate (Aermony Respiclick — Teva Canada Innovation): Indication: Maintenance treatment of asthma in patients 12 years of age and older [BOOK]
- BOOKCanadian Agency for Drugs and Technologies in Health: Ottawa (ON)
- CADTH Canadian Drug Expert Committee Recommendation: Benralizumab (Fasenra — Astrazeneca Canada Inc.): Indication: Severe Eosinophilic Asthma [BOOK]
- BOOKCanadian Agency for Drugs and Technologies in Health: Ottawa (ON)
- TLR4 antagonist ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing inflammatory monocytes infiltration in mice model. [Journal Article]
- IIInt Immunopharmacol 2019 May 20; 73:254-260
- The present study aims to investigate the effects of toll-like receptor 4 (TLR4) antagonist in an ovalbumin (OVA)-induced mouse model of combined allergic rhinitis and asthma syndrome (CARAS). An OVA…
The present study aims to investigate the effects of toll-like receptor 4 (TLR4) antagonist in an ovalbumin (OVA)-induced mouse model of combined allergic rhinitis and asthma syndrome (CARAS). An OVA-induced mouse model of CARAS was established and TLR4 antagonist, TAK-242, was administrated intranasally or intraperitoneally. The number of sneezing and nasal rubbing was counted. The frequency of different cell types in the bronchoalveolar lavage fluid (BALF) and nasal lavage fluid (NLF) was analyzed using flow cytometry. Expressions of protein in nasal mucosa and lungs were determined using western blotting. Levels of interleukin (IL)-4, IL-5, and IL-13 were determined using Enzyme-linked Immunosorbent Assay (ELISA). Histological scores were applied for the assessment of lung injury. Treatment of TAK-242 downregulated CCL2 expression and reduced monocyte infiltration in nasal mucosa and lung tissues. Additionally, treatment of TAK-242 ameliorated upper airway symptoms including the sneezing and nasal rubbing by the regulation of cytokines including IL-4, IL-5, and IL-13. Furthermore, treatment of TAK-242 ameliorated lower airway symptoms including decreasing the frequency of CD45+SiglecF+CD11b+CD11c- eosinophils in BALF and IL13+ Th2 cells in the lungs. In conclusion, treatment of TAK-242 ameliorated CARAS-related lung injury by inhibiting lymphocyte infiltration, reducing monocytes infiltration, as well as regulating the frequency of eosinophils and Th2 cells.
- Extracellular polysaccharide produced by Chlorella vulgaris - Chemical characterization and anti-asthmatic profile. [Journal Article]
- IJInt J Biol Macromol 2019 May 20
- Microalgae are the lowest plant organisms producing a wide range of metabolites that make them interesting organisms for industrial applications. Cultivation of green microalgal species Chlorella vul…
Microalgae are the lowest plant organisms producing a wide range of metabolites that make them interesting organisms for industrial applications. Cultivation of green microalgal species Chlorella vulgaris resulted a significant production of extracellular polysaccharide (EPS). Preliminary chemico-spectroscopic studies on EPS revealed its molecular profile, a complex primary structure consisting of six monosaccharide units occurring in both furano and pyrano forms, a high sugar binding variability and the presence of partially methylated derivatives of some sugar constituents. Biological activity tests showed that EPS caused significant bronchodilatory, anti-inflammatory and antitussive effects in test animals. Chlorella EPS appears to be a promising agent for the prevention of chronic airway inflammation, which is the basic pathogenic mechanism of many respiratory diseases, including bronchial asthma.
- Pediatric Asthma Among Small Racial/Ethnic Minority Groups: An Analysis of the 2006-2015 National Health Interview Survey. [Journal Article]
- PHPublic Health Rep 2019 May 23; :33354919849943
- Few studies have examined the asthma burden among small racial/ethnic minority groups such as Asian children. We examined asthma disparities among children aged 4-17 in 6 small non-Hispanic racial/et…
Few studies have examined the asthma burden among small racial/ethnic minority groups such as Asian children. We examined asthma disparities among children aged 4-17 in 6 small non-Hispanic racial/ethnic minority groups (American Indian/Alaska Native [AI/AN], Asian Indian, Chinese, Filipino, other Asian, and multiple race) by using the 2006-2015 National Health Interview Survey. These small minority groups represented a weighted 6.1% of the study population (6770 of 88 049). The prevalence of current asthma ranged from 5.5% (95% confidence interval [CI], 3.5%-7.5%) among Chinese children to 13.8% (95% CI, 10.4%-17.2%) among multiple-race children and 14.6% (95% CI, 10.8%-18.4%) among AI/AN children. Compared with non-Hispanic white children, AI/AN (adjusted odds ratio [aOR] = 1.6; 95% CI, 1.2-2.2) and multiple-race (aOR = 1.4; 95% CI, 1.0-2.0) children had higher odds for current asthma. Several small racial/ethnic minority groups are at heightened risk of asthma-associated outcomes, highlighting the need for further research on these populations.
- Effect of Spirometry on Exhaled Nitric Oxide Values in Asthmatic Children. [Letter]
- PAPediatr Allergy Immunol 2019 May 23
- Measurement of fractional exhaled nitric oxide (FeNO) is important for asthma management. Regarding interpretation of FeNO, the American Thoracic Society (ATS) / European Respiratory Society (ERS) gu…
Measurement of fractional exhaled nitric oxide (FeNO) is important for asthma management. Regarding interpretation of FeNO, the American Thoracic Society (ATS) / European Respiratory Society (ERS) guidelines recommended that FeNO should be done first because hyperventilation maneuvers like spirometry have been shown to transiently reduce the exhaled NO level (1,2,3,4). However, in daily clinical practice, there are some situations where we want to evaluate FeNO after hyperventilation. Because it is unclear how hyperventilation affects assessment of FeNO, this study was conducted to clarify the influence of hyperventilation (spirometry) on FeNO, and the reliability of the FeNO data obtained in such situation. This article is protected by copyright. All rights reserved.
- IL-16 aggravates OVA-induced allergic inflammation by enhancing Th2 and Th17 cytokine production in a mouse model. [Journal Article]
- IImmunology 2019 May 23
- Asthma is a chronic inflammatory disease that involves a variety of cytokines and cells. Interleukin (IL)-16 is highly expressed during allergic airway inflammation and is involved in its development…
Asthma is a chronic inflammatory disease that involves a variety of cytokines and cells. Interleukin (IL)-16 is highly expressed during allergic airway inflammation and is involved in its development. However, its specific mechanism of action remains unclear. In the present study, we utilized an animal model of ovalbumin (OVA)-induced allergic asthma with mice harboring an IL-16 gene deletion to investigate the role of this cytokine in asthma, in addition to its underlying mechanism. Increased IL-16 expression was observed during OVA-induced asthma in C57BL/6J mice. However, when OVA was used to induce asthma in IL-16-/- mice, a diminished inflammatory reaction, decreased bronchoalveolar lavage fluid (BALF) eosinophil numbers, and the suppression of OVA-specific IgE levels in the serum and BALF were observed. The results also demonstrated decreased levels of Th2 and Th17 cytokines upon OVA-induced asthma in IL-16-/- mice. Thus, we confirmed that IL-16 enhances the lung allergic inflammatory response and suggest a mechanism possibly associated with the upregulation of IgE and the promotion of Th2 and Th17 cytokine production. This work explored the mechanism underlying the regulation of IL-16 in asthma and provides a new target for the clinical treatment of asthma. This article is protected by copyright. All rights reserved.
- Exploring the association between ingestion of foods with higher potential salicylate content and symptom exacerbation in chronic rhinosinusitis. Data from the National Chronic Rhinosinusitis Epidemiology Study. [Journal Article]
- RRhinology 2019 May 23
- CONCLUSIONS: This analysis suggests that there is an association between symptom exacerbation in response to food products with higher potential salicylate content, specifically wine, in CRS patients both with and without nasal polyposis when compared to controls, but especially in the CRSwNPs and AFRS phenotypes. Further studies are needed to detail if this relationship represents a causal relationship to dietary salicylate. The data present the possibility that a wider group of CRS patients may elicit salicylate sensitivity than those with known N-ERD.
- Fractional Exhaled Nitric Oxide (FeNO) Combined with Pulmonary Function Parameters Shows Increased Sensitivity and Specificity for the Diagnosis of Cough Variant Asthma in Children. [Journal Article]
- MSMed Sci Monit 2019 May 23; 25:3832-3838
- CONCLUSIONS: FeNO combined with pulmonary function parameters of MMEF/MEF50 showed increased sensitivity and specificity for the diagnosis of cough variant asthma.
New Search Next
- [Fraction of exhaled nitric oxide as biomarker of asthmatic airway inflammation]. [Journal Article]
- ULUgeskr Laeger 2019 May 06; 181(19)
- Fraction of exhaled nitric oxide (FeNO) is an easily available online biomarker, which correlates with the presence of type 2 inflammation in the airways. Measurements of FeNO together with clinical …
Fraction of exhaled nitric oxide (FeNO) is an easily available online biomarker, which correlates with the presence of type 2 inflammation in the airways. Measurements of FeNO together with clinical assessment and spirometry have the potential to improve diagnosis and management of patients with chronic airway symptoms. High values of FeNO in patients with relevant symptoms increase the probability of asthma and a favourable response to inhaled cortico-steroids, but low values can be seen in various subtypes of asthma and in asthmatic patients, who smoke.