- Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review. [Review]J Perinatol. 2023 Jan 28 [Online ahead of print]JP
- CONCLUSIONS: Significant heterogeneity among studies precludes direct comparisons and generalizability of the results. No specific anesthetic modality for treatment of ROP with laser photocoagulation was shown to be superior in terms of safety. Well-designed studies are required to establish the optimal anesthetic approach, considering that laser photocoagulation still remains one of the main therapeutic modalities for ROP.
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- Endomorphin analog ZH853 shows low reward, tolerance, and affective-motivational signs of withdrawal, while inhibiting opioid withdrawal and seeking. [Journal Article]Neuropharmacology. 2023 Jan 25 [Online ahead of print]N
- Currently available μ-opioid receptor agonist pharmacotherapies for opioid use disorder possess adverse effects limiting their use, and despite treatment, rates of relapse remain high. We previously showed that endomorphin analog ZH853 had no effect in rodent models that predict abuse liability in humans. Here we extended these findings by examining dependence liability and reinforcing properties…
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- Femoral nerve block and local instillation analgesia associated with more reliable efficacy in regional anesthesia interventions within 24 hours following anterior cruciate ligament reconstruction: a network meta-analysis. [Journal Article]Arthroscopy. 2023 Jan 25 [Online ahead of print]A
- CONCLUSIONS: Our meta-analysis shows that FNB and LIA can significantly diminish postoperative pain and reduce opioid consumption following ACLR compared to placebo in the setting of regional anesthesia, and FSNB may be the top 1 ranked analgesic technique despite of high uncertainty.
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- Letter-to-the-editor, concerning the article entitled "Common opioids and stimulants in autopsy and DUID cases: A comparison of measured concentrations.". [Letter]Forensic Sci Int. 2023 Jan 26; 344:111569.FS
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- Opioid use following pelvic reconstructive surgery: a predictive calculator. [Journal Article]Int Urogynecol J. 2023 Jan 28 [Online ahead of print]IU
- CONCLUSIONS: Patients undergoing surgery for pelvic floor disorders use far fewer opioids than they are prescribed.
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- Modulation of the inflammatory response by pre-emptive administration of IMT504 reduces postoperative pain in rats and has opioid-sparing effects. [Journal Article]J Pain. 2023 Jan 24 [Online ahead of print]JP
- Despite the available knowledge on underlying mechanisms and the development of several therapeutic strategies, optimal management of postoperative pain remains challenging. This pre-clinical study hypothesizes that, by promoting an anti-inflammatory scenario, pre-emptive administration of IMT504, a non-coding, non-CpG oligodeoxynucleotide with immune modulating properties, will reduce postincisi…
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- Protein S Deficiency with Recurrent Deep Vein Thrombosis and Post Thrombotic Syndrome: A Case Report. [Journal Article]JNMA J Nepal Med Assoc. 2022 Oct 01; 60(254):892-894.JJ
- Protein S is a vitamin K-dependent protein that acts as a break in secondary hemostasis by inactivating activated factor V and activated factor VIII. We report a case of a 40 years old male who had the first episode of deep vein thrombosis of the left lower limb 10 years back, which despite treatment, reoccurred 3 months later in the bilateral lower limb. Thrombophilic screening showed severe pro…
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- Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. [Journal Article]Cancer Med. 2023 Jan 26 [Online ahead of print]CM
- CONCLUSIONS: L-TAMS outperforms a placebo in enhancing the analgesic effect of opioids and reducing the necessary opioid dosage. Moreover, L-TAMS can significantly relieve opioid-induced constipation. These advantages may be beneficial to patients with advanced cancer.
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- Opioids and constipation therapy in the last week of life: Their impact on patients, caregivers, and the location of death. [Journal Article]
- The use of opioids to control pain at the end of life may cause constipation, a symptom that can negatively influence the well-being of patients and caregivers. The main aim of this study was to evaluate the impact of constipation on symptomatic control and patients' overall quality of life at this stage. A particular focus was placed on opioids. We also intended to investigate whether constipati…
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- Patient-Controlled Analgesia vs Intravenous Push Hydromorphone for Pain Management of Vaso-Occlusive Crisis Associated With Sickle Cell Disease. [Journal Article]J Pain Palliat Care Pharmacother. 2023 Jan 26 [Online ahead of print]JP
- Patient-controlled analgesia (PCA) appears to be the preferred modality for treatment of pain associated with vaso-occlusive crisis (VOC) and is the current standard of therapy at most institutions. With limited data available, this study analyzed the effectiveness of PCA vs intravenous push (IVP) hydromorphone for pain management of VOC. The primary objective was to determine whether PCA or IVP …
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- Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients. [Journal Article]Neurosurgery. 2022 Nov 16 [Online ahead of print]N
- CONCLUSIONS: In a large cohort of opioid-naive postoperative neurosurgical patients, this study demonstrates higher inpatient and outpatient postoperative opioid usage among White patients. Increasing physician awareness to the effect of race on inpatient and outpatient pain management would allow for a modified opioid prescribing practice that ensures limited yet effective opioid dosages void of implicit biases.
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- STRETCH: Stinging tree exposures to Cairns Hospital. [Journal Article]Emerg Med Australas. 2023 Jan 26 [Online ahead of print]EM
- CONCLUSIONS: Stinging tree exposure results in significant presentations to the Cairns ED each year. Pain is immediate and severe and there are no clear first aid or definitive treatment recommendations. Further work is needed to ascertain the best first aid and definitive treatment including a formal trial of dilute HCl.
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- Multimodal Pain Control Reduces Narcotic Use after Outpatient Abdominoplasty: Retrospective Analysis in an Ambulatory Surgery Practice. [Journal Article]Plast Reconstr Surg Glob Open. 2023 Jan; 11(1):e4777.PR
- CONCLUSIONS: Optimally utilizing multimodal medications effectively reduces narcotic consumption while effectively managing postoperative pain from abdominoplasty in a private practice, ambulatory surgery setting. Surgeons must change their prescribing habits if we are going to make progress in the war against the opioid crisis.
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- Opioid Use Disorder from Poppy Seed Tea Use: A Case Report. [Journal Article]Am J Case Rep. 2023 Jan 26; 24:e938675.AJ
- BACKGROUND Unwashed or unprocessed poppy seeds may be an underrecognized substance that can lead to dependence, abuse, and an opioid use disorder. Poppy seeds can be purchased in an unwashed or unprocessed form, and these seeds can be contaminated with the opium alkaloids morphine, codeine, and thebaine on their surfaces. Poppy seeds that are commercially available, such as those used for baking …
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- Long-term Safety, Dose Stability, and Efficacy of Opioids for Patients With Restless Legs Syndrome in the National RLS Opioid Registry. [Journal Article]Neurology. 2023 Jan 25 [Online ahead of print]Neur
- CONCLUSIONS: Low-dose opioid medications continue to adequately control symptoms of refractory RLS over 2 year follow-up in the majority of participants. A minority of patients did see larger dose increases, which were invariably associated with a limited number of factors, most notably changes in opioid and non-opioid RLS medications and opioid use for a non-RLS condition. Continued longitudinal observations will provide insight on the long-term safety and efficacy of opioid treatment of severe, augmented RLS.
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- A Personalized Opioid Prescription Model for Predicting Postoperative Discharge Opioid Needs. [Journal Article]Plast Reconstr Surg. 2023 Feb 01; 151(2):450-460.PR
- CONCLUSIONS: The POP model accurately estimates postdischarge opioid consumption and risk of developing persistent use in plastic surgery patients. Use of the POP model in clinical practice may lead to more appropriate and personalized opioid prescribing.
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- Laparoscopic transversus abdominis plane block is useful in pain relief after laparoscopic stapled repair of diastasis recti and ventral hernia. [Journal Article]J Minim Access Surg. 2023 Jan 09 [Online ahead of print]JM
- CONCLUSIONS: Laparoscopic-guided TAP-block can be considered safe and effective in the management of post-operative pain and in the reduction of analgesic need in patients undergoing laparoscopic repair of diastasis recti and ventral hernias. The non-randomised nature of the study and the lack of a consistent series of patients require further evaluations.
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- Assessment of abuse potential of carfentanil. [Journal Article]Addict Biol. 2023 Feb; 28(2):e13265.AB
- Carfentanil, as a fentanyl analogue, is a potent synthetic opioid. It has been controlled in many countries, and its emergence has been highlighted by many recent reports. However, although discriminative stimulus effects of carfentanil in rats had been reported, its abuse potential has not been fully evaluated. In this study, we evaluated the abuse potential of carfentanil via the tests of condi…
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- Emergence of restless legs syndrome during opioid discontinuation. [Journal Article]J Clin Sleep Med. 2023 Jan 24 [Online ahead of print]JC
- CONCLUSIONS: Moderately severe symptoms of RLS, as assessed by survey, occur commonly in individuals undergoing opioid tapering, particularly if exposed to higher doses. In many cases, symptoms appear to be self-limited, although a minority develop persistent symptoms. Our results may have implications for successful opioid tapering, but future confirmatory studies with structured clinician interview are needed to establish that these symptoms truly represent restless legs syndrome given the potential for RLS-mimicking symptoms in individuals with chronic pain syndromes.
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- Addition of infiltration between the popliteal artery and the capsule of the posterior knee (IPACK) to local infiltration analgesia for total knee arthroplasty: a prospective randomized controlled trial. [Journal Article]J Arthroplasty. 2023 Jan 20 [Online ahead of print]JA
- CONCLUSIONS: This randomized controlled trial demonstrated that there were significantly lower pain scores, less opioid consumption, and better functional results with LIA+IPACK and LIA when compared with IPACK alone, suggesting that IPACK alone was inferior for pain control.
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- Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. [Journal Article]Prehosp Emerg Care. 2023 Jan 23 [Online ahead of print]PE
- Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths. Ketamine, fentanyl, and morphine are recommended analgesics for use in the prehospital (i.e., field) setting to reduce pain. However, it is unknown whether any of these analgesics reduce hemorrhagic tolerance in humans. We tested the hypothesis that fentanyl (75 µg) and morphine (5 mg), but not ketamine (20 mg), …
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- Opportunistic salpingectomy during robotic sacrocolpopexy: Data to support a widely accepted practice. [Journal Article]
- While surgical outcomes of prophylactic salpingectomy as an ovarian cancer risk reducing measure at the time of hysterectomy for benign indications has already been studied, data has traditionally been extrapolated to surgery for prolapse repair. A retrospective chart review was performed from medical records of patients who had undergone a sacrocolpopexy for pelvic organ prolapse. Variables coll…
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- Epidural esketamine and morphine for postoperative analgesia after caesarean delivery: A pilot study. [Journal Article]
- CONCLUSIONS: The addition of esketamine to morphine improved postoperative analgesia after cesarean section without increasing the incidence of adverse events.
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- Evaluating the Influence of IV Ketamine on Postoperative Opioid Use for Surgical Patients at a Tertiary Care Centre. [Journal Article]
- CONCLUSIONS: Overall, subanesthetic doses of IV ketamine used postoperatively in surgical patients did not decrease opioid use or patient-reported pain. More patients who received ketamine had documented hallucinations. These results will help guide postoperative analgesia practice and strategies to reduce opioid use.
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- Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells. [Journal Article]
- CONCLUSIONS: ZnO QDs did not affect cell viability in a CCK8 assay, but disturbed the level of intracellular metabolites and proteins at 20 µg/mL. The KEGG analyses of the metabolomics and proteomics data both enriched the alcoholism and Cushing syndrome pathways. These results provide an experimental basis for future research on the safe use of nanomaterials.
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- How to wean friends and influence health: Opioid weaning and discontinuation aided by a simple health and wellness coaching program. [Journal Article]J Opioid Manag. 2023 Jan-Feb; 19(1):57-67.JO
- CONCLUSIONS: Providing simple and salient HWC including PNE within pain management can significantly improve opioid weaning and discontinuation while mitigating pain.
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- Monitoring long-term opioid therapy and chronic noncancer pain in primary care: Whole Health Primary Care Pain Education and Opioid Monitoring Program (PC-POP). [Journal Article]J Opioid Manag. 2023 Jan-Feb; 19(1):19-33.JO
- CONCLUSIONS: PC-POP increases guideline concordant care for providers working in primary care.
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- Highly oxygenated grayanane diterpenoids with structural diversity from the flowers of Rhododendron dauricum and their analgesic activities. [Journal Article]Bioorg Chem. 2023 Jan 16; 132:106374.BC
- Twenty-eight grayanane diterpenoids (1-28) including 13 new ones, named daublossomins A-M (1-13), and two new natural products, 3-O-acetylgrayanotoxin II (14) and 10-epi-grayanotoxin III (15), were isolated from the flowers of Rhododendron dauricum L. (Ericaceae). Their structures were elucidated by means of comprehensive spectroscopic methods and quantum chemical calculations (13C NMR-DP4+ analy…
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- Intravenous Hydromorphone Versus Intravenous Acetaminophen for Older Adult Patients: More to Think About. [Letter]Ann Emerg Med. 2023 Feb; 81(2):246-247.AE
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- Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain. [Journal Article]Toxicol Appl Pharmacol. 2023 Jan 18; 461:116382.TA
- Dysfunction of the central nervous system are accompanied by changes in tryptophan metabolism, with the kynurenine pathway (KP) being the main route of its catabolism. Recently, KP metabolites, which are collectively called kynurenines, have become an area of intense research due to their ability to directly and indirectly affect a variety of classic neurotransmitter systems. However, the signifi…
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