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81 results
  • Effects of Daily Methocinnamox Treatment on Fentanyl Self-Administration in Rhesus Monkeys. [Journal Article]
    J Pharmacol Exp Ther. 2022 08; 382(2):181-187.Maguire DR, France CP
  • Methocinnamox (MCAM), a long-acting μ-opioid receptor antagonist, attenuates the positive reinforcing effects of opioids, such as heroin and fentanyl, suggesting it could be an effective treatment of opioid use disorder (OUD). Because treatment of OUD often involves repeated administration of a medication, this study evaluated effects of daily injections of a relatively small dose of MCAM on fent…
  • Methadone, Buprenorphine, Oxycodone, Fentanyl and Tramadol in Multiple Postmortem Matrices. [Journal Article]
    J Anal Toxicol. 2022 Jul 14; 46(6):600-610.Havig SM, Vindenes V, … Thaulow CH
  • Peripheral blood (PB) concentrations are generally preferred for postmortem toxicological interpretation, but some autopsy cases may lack blood for sampling due to decomposition or large traumas, etc. In such cases, other tissues or bodily fluids must be sampled; however, limited information exists on postmortem concentrations in matrices other than blood. Pericardial fluid (PF), muscle and vitre…
  • Methocinnamox Reverses and Prevents Fentanyl-Induced Ventilatory Depression in Rats. [Journal Article]
    J Pharmacol Exp Ther. 2021 04; 377(1):29-38.Jimenez VM, Castaneda G, France CP
  • Opioid use disorder affects over 2 million Americans with an increasing number of deaths due to overdose from the synthetic opioid fentanyl and its analogs. The Food and Drug Administration-approved opioid receptor antagonist naloxone (e.g., Narcan) is used currently to treat overdose; however, a short duration of action limits its clinical utility. Methocinnamox (MCAM) is a long-lasting opioid r…
  • Demographic and Perioperative Factors Associated With Patient-reported Outcomes Measurement Information System (PROMIS) Survey Completion. [Journal Article]
    Clin Spine Surg. 2020 12; 33(10):E519-E524.Parrish JM, Jenkins NW, … Singh K
  • CONCLUSIONS: This study identified demographic and perioperative variables associated with PROMIS survey completion and response rates. Patients who underwent surgery in the outpatient setting and those with high preoperative radicular limb pain were less likely to complete surveys. Interestingly, patients with clinical signs of depression were more likely to fill out surveys. Understanding variables associated with survey completion may provide the clinician with insight into which demographic groups are the most at-risk for not responding to surveys.
  • OREX-1019: A Novel Treatment of Opioid Use Disorder and Relapse Prevention. [Journal Article]
    J Pharmacol Exp Ther. 2020 02; 372(2):205-215.Maguire DR, Gerak LR, … Flynn P
  • There is an urgent need for new pharmacological treatments for substance use disorders, including opioid use disorder, particularly for use in relapse prevention. A combination of buprenorphine with naltrexone has shown particular promise, with clinical studies indicating a substantial improvement over treatment with naltrexone alone. OREX-1019 (formerly BU10119) is a compound that mimics the pha…
  • Long-Lasting Effects of Methocinnamox on Opioid Self-Administration in Rhesus Monkeys. [Journal Article]
    J Pharmacol Exp Ther. 2019 01; 368(1):88-99.Maguire DR, Gerak LR, … France CP
  • Opioid abuse remains a serious public health challenge, despite the availability of medications that are effective in some patients (naltrexone, buprenorphine, and methadone). This study explored the potential of a pseudoirreversible mu-opioid receptor antagonist [methocinnamox (MCAM)] as a treatment for opioid abuse by examining its capacity to attenuate the reinforcing effects of mu-opioid rece…
  • Increases in Fentanyl-Related Overdose Deaths - Florida and Ohio, 2013-2015. [Journal Article]
    MMWR Morb Mortal Wkly Rep. 2016 Aug 26; 65(33):844-9.Peterson AB, Gladden RM, … Goldberger BA
  • In March and October 2015, the Drug Enforcement Administration (DEA) and CDC issued nationwide alerts identifying fentanyl, particularly illicitly manufactured fentanyl (IMF), as a threat to public health and safety (1,2). IMF is pharmacologically similar to pharmaceutical fentanyl (PF), but is unlawfully produced in clandestine laboratories, obtained via illicit drug markets, and includes fentan…
  • Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice. [Journal Article]
    Drug Alcohol Depend. 2015 Jan 01; 146:7-16.Gamage TF, Ignatowska-Jankowska BM, … Lichtman AH
  • CONCLUSIONS: These findings suggest that inhibiting endocannabinoid catabolic enzymes reduces somatic morphine withdrawal signs, but not aversive aspects as inferred in the CPA paradigm. The observation that non-dependent mice administered inhibitors of endocannabinoid degradation did not display place preferences is consistent with the idea that that endocannabinoid catabolic enzymes might be targeted therapeutically, with reduced risk of abuse.
  • Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. [Randomized Controlled Trial]
    J Pharmacol Exp Ther. 2014 11; 351(2):259-69.Winchester WJ, Gore K, … Reynolds DS
  • The transient receptor potential (subfamily M, member 8; TRPM8) is a nonselective cation channel localized in primary sensory neurons, and is a candidate for cold thermosensing, mediation of cold pain, and bladder overactivity. Studies with TRPM8 knockout mice and selective TRPM8 channel blockers demonstrate a lack of cold sensitivity and reduced cold pain in various rodent models. Furthermore, T…
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